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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Agtr1a
angiotensin II receptor, type 1a
MGI:87964
73 phenotypes from 12 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Agtr1aem1(IMPC)Rbrc/\Agtr1aem1(IMPC)Rbrc
C57BL/6NJcl-Agtr1aem1(IMPC)Rbrc/Rbrc 		abnormal heart morphology J:211773
abnormal kidney morphology J:211773
abnormal spleen morphology J:211773
decreased erythrocyte cell number J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased mean corpuscular hemoglobin J:211773
enlarged heart J:211773
enlarged spleen J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
polycystic kidney J:211773
thrombocytosis J:211773
\Agtr1atm1.1Cof/\Agtr1atm1.1Cof
\Hprt1tm1(Pck1-cre)Vhh/\Hprt1+
involves: 129 * 129P2/OlaHsd 		abnormal renal water reabsorption J:172240
decreased renal glomerular filtration rate J:172240
decreased systemic arterial systolic blood pressure J:172240
\Agtr1atm1.1Uky/\Agtr1atm1.1Uky
\Tg(Fabp4-cre)1Rev/0
involves: C57BL/6 * C57BL/6N * SJL 		abnormal adipose tissue development J:192945
normal adipose tissue phenotype J:192945
decreased white fat cell number J:192945
normal growth/size/body region phenotype J:192945
normal homeostasis/metabolism phenotype J:192945
increased white fat cell size J:192945
\Agtr1atm1Afu/\Agtr1a+
involves: C57BL/6 * CBA * ICR 		decreased systemic arterial systolic blood pressure J:28041
normal homeostasis/metabolism phenotype J:28041
hypotension J:28041
\Agtr1atm1Afu/\Agtr1atm1Afu
involves: C57BL/6 * CBA 		abnormal kidney interstitium morphology J:69294
decreased susceptibility to injury J:100334
hypotension J:91164
\Agtr1atm1Afu/\Agtr1atm1Afu
involves: C57BL/6 * CBA * ICR 		decreased systemic arterial systolic blood pressure J:28041, J:107851
hypotension J:28041
increased circulating renin level J:28041
increased fluid intake J:107851
increased renin activity J:28041
\Agtr1atm1Ecl/\Agtr1atm1Ecl
involves: 129S2/SvPas * C57BL/6 		abnormal blood homeostasis J:124206
abnormal cardiovascular system physiology J:124206
abnormal heart left ventricle morphology J:124206
abnormal kidney physiology J:124206
abnormal kidney vasculature morphology J:124206
cardiac fibrosis J:124206
cardiac interstitial fibrosis J:124206
decreased body weight J:124206
decreased circulating angiotensin II level J:124206
decreased circulating renin level J:124206
decreased physiological sensitivity to xenobiotic J:124206
decreased urine creatinine level J:124206
decreased urine potassium level J:124206
high mean erythrocyte cell number J:124206
increased blood urea nitrogen level J:124206
increased heart weight J:124206
increased hemoglobin content J:124206
increased systemic arterial systolic blood pressure J:124206
increased urine osmolality J:124206
oliguria J:124206
renal fibrosis J:124206
\Agtr1atm1Tma/\Agtr1atm1Tma
involves: 129P2/OlaHsd * C57BL/6 		abnormal juxtaglomerular apparatus morphology J:36090
abnormal kidney interlobular artery morphology J:36090
increased systemic arterial blood pressure J:46007
juxtaglomerular cell hyperplasia J:36090
\Agtr1atm1Uky/\Agtr1atm1Uky
\Tg(Tagln-cre)1Her/0
involves: C57BL/6 * C57BL/6N * SJL 		normal cardiovascular system phenotype J:170230
\Agtr1atm1Unc/\Agtr1a+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal systemic arterial blood pressure J:24354
decreased systemic arterial blood pressure J:24354
decreased systemic arterial systolic blood pressure J:24354
\Agtr1atm1Unc/\Agtr1atm1Unc
involves: 129P2/OlaHsd 		abnormal amygdala morphology J:102774
abnormal thalamus morphology J:102774
\Agtr1atm1Unc/\Agtr1atm1Unc
involves: 129P2/OlaHsd * C57BL/6 		abnormal heart rate J:137944
abnormal physiological response to xenobiotic J:137944
abnormal response/metabolism to endogenous compounds J:137944
abnormal systemic arterial blood pressure J:137944
decreased heart rate J:137944
decreased heart weight J:137944
decreased mean systemic arterial blood pressure J:137944
\Agtr1atm1Unc/\Agtr1atm1Unc
involves: 129P2/OlaHsd * C57BL/6J 		abnormal systemic arterial blood pressure J:24354
decreased systemic arterial blood pressure J:24354
decreased systemic arterial systolic blood pressure J:24354
\Agtr1atm2Tma/\Agtr1atm2Tma
involves: 129P2/OlaHsd * C57BL/6 		abnormal juxtaglomerular apparatus morphology J:36090
abnormal kidney interlobular artery morphology J:36090
juxtaglomerular cell hyperplasia J:36090
\Agtr1atm3Tma/\Agtr1atm3Tma
\Tg(Nphs1-cre)10Mska/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		normal cardiovascular system phenotype J:240316
normal homeostasis/metabolism phenotype J:240316
normal renal/urinary system phenotype J:240316
\Hprt1tm1(Ggt1-Agtr1)Cof/Y
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:91837
\Tg(Myh6-Agtr1a)4-7Vjd/0
FVB/N-Tg(Myh6-Agtr1a)4-7Vjd 		abnormal impulse conducting system conduction J:40974
atrioventricular block J:40974
decreased heart rate J:40974
heart hyperplasia J:40974
increased heart atrium size J:40974
increased heart weight J:40974
perinatal lethality, incomplete penetrance J:40974
prolonged PR interval J:40974
prolonged QRS complex duration J:40974
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03/25/2025
MGI 6.24 		The Jackson Laboratory