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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Agtr2
angiotensin II receptor, type 2
MGI:87966
103 phenotypes from 3 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi 		decreased body weight J:175295
decreased circulating alanine transaminase level J:175295
decreased circulating LDL cholesterol level J:175295
Agtr2tm1Gsb/Y
FVB.129-Agtr2tm1Gsb 		abnormal response to cardiac infarction J:103066
abnormal systemic arterial blood pressure J:103237
abnormal vascular smooth muscle morphology J:103237
abnormal vasculogenesis J:103237
abnormal vasoconstriction J:103237
dilated heart left ventricle J:103066
increased susceptibility to induced morbidity/mortality J:103066
increased vasoconstriction J:103376
vascular smooth muscle hypertrophy J:103376
Agtr2tm1Gsb/Y
involves: 129S1/Sv * 129X1/SvJ 		increased susceptibility to injury J:100334
Agtr2tm1Gsb/Y
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal fluid intake J:29456
abnormal systemic arterial blood pressure J:29456
decreased locomotor activity J:29456
increased fluid intake J:107851
increased systemic arterial systolic blood pressure J:107851
Agtr2tm1Gsb/Agtr2tm1Gsb
involves: 129S1/Sv * 129X1/SvJ 		increased susceptibility to injury J:100334
Agtr2tm1Tin/Y
B6.129P2-Agtr2tm1Tin 		abnormal heart left ventricle morphology J:146723
abnormal myocardial fiber morphology J:63751
abnormal response to cardiac infarction J:146723
cardiac fibrosis J:63751, J:146723
decreased heart left ventricle posterior wall thickness J:63751
decreased heart left ventricle weight J:146723
decreased response of heart to induced stress J:63751
increased susceptibility to induced morbidity/mortality J:146723
thin interventricular septum J:63751
Agtr2tm1Tin/Y
involves: 129P2/OlaHsd 		abnormal amygdala morphology J:102774
abnormal baroreceptor physiology J:103144
abnormal circulating insulin level J:105210
abnormal circulating leptin level J:105210
abnormal eating behavior J:105210
abnormal epididymal fat pad morphology J:105210
abnormal glucose homeostasis J:105210
abnormal habenula morphology J:102774
abnormal hippocampus CA1 region morphology J:102774
abnormal hippocampus CA2 region morphology J:102774
abnormal hippocampus CA3 region morphology J:102774
abnormal kidney cortex morphology J:48005
abnormal lipid homeostasis J:105210
abnormal piriform cortex morphology J:102774
abnormal respiratory quotient J:105210
abnormal response/metabolism to endogenous compounds J:105210
abnormal skeletal muscle triglyceride level J:105210
abnormal systemic arterial blood pressure J:105210
abnormal thalamus morphology J:102774
abnormal urine homeostasis J:60075
abnormal urine sodium level J:60075
decreased angiogenesis J:118914
decreased kidney apoptosis J:48005
decreased renal plasma flow rate J:60075
decreased susceptibility to diet-induced obesity J:105210
decreased susceptibility to weight gain J:105210
decreased white fat cell size J:105210
increased angiogenesis J:118914
increased energy expenditure J:105210
increased insulin sensitivity J:105210
increased mean systemic arterial blood pressure J:103144
increased physiological sensitivity to xenobiotic J:103144
increased renal vascular resistance J:60075
increased systemic arterial blood pressure J:103144
increased white fat cell number J:105210
renal interstitial fibrosis J:48005
Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6 		abnormal aldosterone level J:102984
abnormal bone trabecula morphology J:147915
abnormal corticosterone level J:102984
abnormal heart rate J:137944
abnormal kidney development J:52542
abnormal kidney morphology J:52542
abnormal pancreas morphology J:146326
abnormal renal/urinary system morphology J:52542
abnormal renal/urinary system physiology J:52542
abnormal response/metabolism to endogenous compounds J:137944
abnormal ureter development J:52542
abnormal ureter morphology J:52542
absent kidney J:52542
decreased body temperature J:29457
decreased exploration in new environment J:29457
decreased heart weight J:137944
decreased kidney weight J:137944
decreased pancreas weight J:146326
decreased startle reflex J:29457
double ureter J:52542
ectopic kidney J:52542
hydronephrosis J:52542
hydroureter J:52542
hypoalgesia J:29457
increased adrenaline level J:102984
increased bone trabecula number J:147915
increased bone volume J:147915
increased circulating adrenocorticotropin level J:102984
increased circulating corticosterone level J:102984
increased fear-related response J:29457
increased mean systemic arterial blood pressure J:137944
increased noradrenaline level J:102984
increased physiological sensitivity to xenobiotic J:146326
increased systemic arterial blood pressure J:29457
increased systemic arterial diastolic blood pressure J:29457
increased systemic arterial systolic blood pressure J:29457
increased trabecular bone connectivity density J:147915
increased trabecular bone thickness J:147915
large ureter J:52542
pancreas fibrosis J:146326
pancreatic acinar cell atrophy J:146326
polycystic kidney J:52542
renal hypoplasia J:52542
ureteropelvic junction atresia J:52542
ureteropelvic junction stenosis J:52542
ureterovesical junction obstruction J:52542
Agtr2tm1Tin/Y
SWR.129P2-Agtr2tm1Tin 		decreased incidence of tumors by chemical induction J:101726
Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd 		abnormal urine homeostasis J:60075
abnormal urine sodium level J:60075
decreased renal plasma flow rate J:60075
increased renal vascular resistance J:60075
Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6 		abnormal aldosterone level J:102984
abnormal corticosterone level J:102984
abnormal heart rate J:137944
abnormal kidney development J:52542
abnormal kidney morphology J:52542
abnormal pancreas morphology J:146326
abnormal renal/urinary system morphology J:52542
abnormal renal/urinary system physiology J:52542
abnormal response/metabolism to endogenous compounds J:137944
abnormal ureter development J:52542
absent kidney J:52542
decreased heart weight J:137944
decreased kidney weight J:137944
decreased pancreas weight J:146326
dilated ureter J:52542
double ureter J:52542
ectopic kidney J:52542
hydronephrosis J:52542
hydroureter J:52542
increased adrenaline level J:102984
increased circulating adrenocorticotropin level J:102984
increased circulating corticosterone level J:102984
increased mean systemic arterial blood pressure J:137944
increased noradrenaline level J:102984
increased physiological sensitivity to xenobiotic J:146326
large ureter J:52542
pancreas fibrosis J:146326
pancreatic acinar cell atrophy J:146326
polycystic kidney J:52542
renal hypoplasia J:52542
ureteropelvic junction atresia J:52542
ureteropelvic junction stenosis J:52542
ureterovesical junction obstruction J:52542
vesicoureteral reflux J:52542
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12/10/2024
MGI 6.24 		The Jackson Laboratory