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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Alpl
alkaline phosphatase, liver/bone/kidney
MGI:87983
49 phenotypes from 11 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
AlplALPLD1/?
involves: C3HeB/FeJ 		decreased circulating alkaline phosphatase level J:68708, J:187875
AlplBAP023/AlplBAP023
C3HeB/FeJ-AlplBAP023 		decreased circulating alkaline phosphatase level J:183993
AlplHpp/Alpl+
involves: BALB/cAnN * C3H/HeH 		decreased circulating alkaline phosphatase level J:82809, J:122319
AlplHpp/AlplHpp
involves: BALB/cAnN * C3H/HeH 		decreased circulating alkaline phosphatase level J:122319
AlplMhdabap020/AlplMhdabap020
C3HeB/FeJ-AlplMhdabap020/Ieg 		decreased circulating alkaline phosphatase level J:183993
AlplMhdabap26/AlplMhdabap26
C3HeB/FeJ-AlplMhdabap26 		decreased circulating alkaline phosphatase level J:183993
AlplMhdabap27/AlplMhdabap27
C3HeB/FeJ-AlplMhdabap27 		decreased circulating alkaline phosphatase level J:183993
AlplMhdabap32/AlplMhdabap32
C3HeB/FeJ-AlplMhdabap32 		decreased circulating alkaline phosphatase level J:183993
AlplSAP007/AlplSAP007
C3HeB/FeJ-AlplSAP007 		decreased circulating alkaline phosphatase level J:183993
Alpltm1Jlm/Alpltm1Jlm
either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J) 		abnormal digestion J:39015
abnormal long bone metaphysis morphology J:39015
abnormal muscle morphology J:39015
abnormal osteoblast morphology J:39015
abnormal small intestine morphology J:39015
abnormal spinal nerve morphology J:39015
abnormal spleen morphology J:39015
abnormal thymus cortex morphology J:39015
apnea J:39015
cachexia J:39015
decreased bone mineralization J:39015
decreased circulating alkaline phosphatase level J:39015
decreased leukocyte cell number J:39015
decreased long bone epiphyseal plate size J:39015
decreased total body fat amount J:39015
fragile skeleton J:39015
impaired coordination J:39015
internal hemorrhage J:39015
intracranial hemorrhage J:39015
lung hemorrhage J:39015
pale spleen J:39015
postnatal lethality, complete penetrance J:39015
seizures J:39015
small spleen J:39015
thin parietal bone J:39015
weakness J:39015
Alpltm1Jlm/Alpltm1Jlm
involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6 		abnormal alveolar process morphology J:233260
abnormal cementum morphology J:233260
abnormal dentin mineralization J:233260
abnormal odontoblast morphology J:233260
abnormal tooth development J:233260
abnormal tooth root development J:233260
abnormal tooth root morphology J:233260
decreased bone mineralization J:233260
enlarged dental pulp chamber J:233260
short tooth root J:233260
Alpltm1Jlm/Alpltm1Jlm
involves: 129S2/SvPas * C57BL/6 		abnormal osteoblast physiology J:128077
decreased bone mineral density J:128077
Alpltm1Sor/Alpltm1Sor
either: (involves: 129S7/SvEvBrd-Alpltm1Sor) or (involves: 129S7/SvEvBrd * C57BL/6) 		abnormal blood homeostasis J:28394
abnormal tooth morphology J:28394
decreased body size J:28394
postnatal lethality, complete penetrance J:28394
seizures J:28394
Alpltm2.1Jlm/Alpl+
involves: 129S4/SvJaeSor * C57BL/6 		abnormal acellular cementum morphology J:237759
abnormal alveolar process morphology J:237759
abnormal cellular cementum morphology J:237759
abnormal cementum mineralization J:237759
abnormal parietal bone morphology J:237759
decreased alkaline phosphatase activity J:237759
decreased bone mineralization J:237759
decreased trabecular bone thickness J:237759
delayed bone mineralization J:237759
increased bone resorption J:237759
increased bone trabecula number J:237759
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory