Alox15 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Alox15
arachidonate 15-lipoxygenase
MGI:87997

35 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alox15^tm1.1Nadl/Alox15^tm1.1Nadl Tg(Pdx1-cre)89.1Dam/0 involves: C57BL/6 * CBA	abnormal enzyme/coenzyme level	J:224344
	abnormal pancreas physiology	J:224344
	abnormal pancreatic beta cell physiology	J:224344
	abnormal redox activity	J:224344
	decreased susceptibility to non-insulin-dependent diabetes	J:224344
	normal growth/size/body region phenotype	J:224344
	improved glucose tolerance	J:224344
	increased insulin secretion	J:224344
	increased pancreatic beta cell mass	J:224344
	pancreatic islet hyperplasia	J:224344
Alox15^tm1.2Nadl/Alox15^tm1.2Nadl involves: C57BL/6	abnormal systemic arterial blood pressure	J:207723
Alox15^tm1.2Nadl/Alox15^tm1.2Nadl involves: C57BL/6	normal cardiovascular system phenotype	J:207723
Alox15^{tm1b(KOMP)Mbp}/Alox15^{tm1b(KOMP)Mbp} C57BL/6N-Alox15^{tm1b(KOMP)Mbp}/Tcp	persistence of hyaloid vascular system	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Alox15^tm1Fun/Alox15^tm1Fun B6.129S2-Alox15^tm1Fun	normal immune system phenotype	J:197334
Alox15^tm1Fun/Alox15^tm1Fun B6.129S2-Alox15^tm1Fun/J	abnormal bone marrow cell number	J:119405
	abnormal lymph node morphology	J:119405
	abnormal myeloblast morphology/development	J:119405
	abnormal myelopoiesis	J:119405
	abnormal spleen red pulp morphology	J:119405
	abnormal spleen white pulp morphology	J:119405
	anemia	J:119405
	decreased spleen B cell follicle number	J:119405
	dermatitis	J:119405
	increased basophil cell number	J:119405
	increased chronic myelocytic leukemia incidence	J:119405
	increased leukocyte cell number	J:119405
	increased spleen weight	J:119405
	intermingled spleen red and white pulp	J:119405
	premature death	J:119405
Alox15^tm1Fun/Alox15^tm1Fun involves: 129/Sv * C57BL/6	abnormal immune system physiology	J:44778
	normal endocrine/exocrine gland phenotype	J:44778
	normal hematopoietic system phenotype	J:44778
	normal reproductive system phenotype	J:44778
Tg(CAG-cat,-ALOX15)1868Klv/Tg(CAG-cat,-ALOX15)1868Klv Tg(Pbsn-cre)4Prb/? involves: C57BL/6 * DBA/2	increased prostate intraepithelial neoplasia incidence	J:114903
Tg(CAG-cat,-ALOX15)1868Klv/0 Tg(Pbsn-cre)4Prb/0 involves: C57BL/6 * DBA/2	increased prostate intraepithelial neoplasia incidence	J:114903

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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