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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ank1
ankyrin 1, erythroid
MGI:88024
109 phenotypes from 8 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ank1ity16/Ank1+
involves: 129S1/Sv * 129X1/SvJ * DBA/2J 		extramedullary hematopoiesis J:199427
increased erythrocyte cell number J:199427
increased kidney iron level J:199427
increased liver iron level J:199427
increased susceptibility to bacterial infection J:199427
increased susceptibility to bacterial infection induced morbidity/mortality J:199427
Ank1ity16/Ank1ity16
involves: 129S1/Sv * 129X1/SvJ * DBA/2J 		abnormal erythrocyte morphology J:199427
abnormal erythropoiesis J:199427
abnormal glomerular mesangium morphology J:199427
anisocytosis J:199427
decreased body weight J:199427
decreased erythrocyte cell number J:199427
decreased hematocrit J:199427
decreased hemoglobin content J:199427
decreased spleen iron level J:199427
enlarged spleen J:199427
glomerulonephritis J:199427
hemolytic anemia J:199427
increased blood urea nitrogen level J:199427
increased circulating alanine transaminase level J:199427
increased circulating aspartate transaminase level J:199427
increased circulating bilirubin level J:199427
increased heart weight J:199427
increased kidney iron level J:199427
increased kidney weight J:199427
increased leukocyte cell number J:199427
increased liver iron level J:199427
increased lymphocyte cell number J:199427
increased neutrophil cell number J:199427
increased susceptibility to bacterial infection J:199427
increased susceptibility to bacterial infection induced morbidity/mortality J:199427
jaundice J:199427
liver abscess J:199427
reticulocytosis J:199427
Ank1M1Btlr/Ank1+
C57BL/6J-Ank1m1Btlr 		decreased mean corpuscular hemoglobin J:203831
decreased mean corpuscular volume J:203831
hemolysis J:203831
increased circulating bilirubin level J:203831
increased erythrocyte cell number J:203831
increased erythrocyte osmotic fragility J:203831
Ank1M1Btlr/Ank1M1Btlr
C57BL/6J-Ank1m1Btlr 		abnormal erythrocyte morphology J:203831
abnormal spleen morphology J:203831
decreased mean corpuscular hemoglobin J:203831
decreased mean corpuscular volume J:203831
enlarged spleen J:203831
extramedullary hematopoiesis J:203831
hemolysis J:203831
increased circulating bilirubin level J:203831
increased circulating erythropoietin level J:203831
increased erythrocyte cell number J:203831
increased erythrocyte osmotic fragility J:203831
increased spleen iron level J:203831
microcytosis J:203831
reticulocytosis J:203831
spherocytosis J:203831
stomatocytosis J:203831
Ank1M1Wlst/Ank1+
C3.B6-Ank1M1Wlst 		decreased cellular hemoglobin content J:170562
decreased mean corpuscular hemoglobin concentration J:170562
decreased mean corpuscular volume J:170562
increased erythrocyte cell number J:170562
increased erythrocyte osmotic fragility J:170562
polychromatophilia J:170562
reticulocytosis J:170562
Ank1M1Wlst/Ank1+
involves: 129S1/SvImJ * C3H/HeJ * C57BL/6 		abnormal erythrocyte morphology J:170562
enlarged spleen J:170562
Ank1M1Wlst/Ank1+
involves: C3H/HeJ * C57BL/6 		decreased cellular hemoglobin content J:170562
decreased mean corpuscular volume J:170562
increased erythrocyte cell number J:170562
Ank1M1Wlst/Ank1M1Wlst
C3.B6-Ank1M1Wlst 		preweaning lethality, complete penetrance J:170562
Ank1M1Wlst/Ank1M1Wlst
involves: 129S1/SvImJ * C3H/HeJ * C57BL/6 		abnormal common myeloid progenitor cell morphology J:170562
abnormal erythrocyte morphology J:170562
abnormal myelopoiesis J:170562
decreased birth weight J:170562
decreased body size J:170562
decreased body weight J:170562
decreased common myeloid progenitor cell number J:170562
decreased fetal weight J:170562
decreased hematocrit J:170562
enlarged heart J:170562
enlarged spleen J:170562
erythroblastosis J:170562
extramedullary hematopoiesis J:170562
gallstones J:170562
hemolytic anemia J:170562
increased erythroid progenitor cell number J:170562
increased nucleated erythrocyte cell number J:170562
jaundice J:170562
pallor J:170562
polychromatophilia J:170562
postnatal growth retardation J:170562
postnatal lethality, incomplete penetrance J:170562
premature death J:170562
reticulocytosis J:170562
spherocytosis J:170562
Ank1M1Wlst/Ank1M1Wlst
involves: C3H/HeJ * C57BL/6 		abnormal leukocyte cell number J:170562
decreased hematocrit J:170562
decreased hemoglobin content J:170562
decreased mean corpuscular hemoglobin concentration J:170562
decreased mean corpuscular volume J:170562
increased erythrocyte cell number J:170562
Ank1MRI23420/Ank1+
SJL/J-Ank1MRI23420 		abnormal erythrocyte morphology J:187820
abnormal spleen morphology J:187820
anemia J:187820
decreased mean corpuscular hemoglobin J:187820
decreased mean corpuscular volume J:187820
decreased susceptibility to parasitic infection J:187820
decreased susceptibility to parasitic infection induced morbidity/mortality J:187820
enlarged spleen J:187820
hyperchromasia J:187820
increased erythrocyte cell number J:187820
increased erythrocyte osmotic fragility J:187820
increased spleen iron level J:187820
increased spleen weight J:187820
microcytosis J:187820
polycythemia J:187820
thrombocytosis J:187820
Ank1MRI23420/Ank1MRI23420
SJL/J-Ank1MRI23420 		abnormal erythrocyte morphology J:187820
enlarged spleen J:187820
increased spleen weight J:187820
jaundice J:187820
neonatal lethality, incomplete penetrance J:187820
poikilocytosis J:187820
postnatal lethality, complete penetrance J:187820
prenatal lethality, incomplete penetrance J:187820
spherocytosis J:187820
Ank1nb/Ank1+
involves: C57BL/6J * WB/Re 		abnormal erythrocyte morphology J:111131
decreased susceptibility to parasitic infection J:111131
increased erythrocyte protoporphyrin level J:5985
Ank1nb/Ank1nb
(WB.Cg-Ank1nb/BrkJ x B6.Cg-Ank1nb/BrkJ)F1 		abnormal cardiac thrombosis J:62355
abnormal erythrocyte morphology J:62355
abnormal erythrocyte physiology J:162532
anisopoikilocytosis J:162532
cardiac hypertrophy J:162532
decreased body size J:162532
decreased hematocrit J:162532
decreased hemoglobin content J:162532
enlarged liver J:162532
enlarged spleen J:162532
extramedullary hematopoiesis J:162532
hemolysis J:162532
hemolytic anemia J:162532
increased circulating bilirubin level J:162532
increased erythrocyte clearance J:162532
increased erythrocyte osmotic fragility J:162532
increased nucleated erythrocyte cell number J:162532
infertility J:162532
jaundice J:162532
low mean erythrocyte cell number J:162532
microcytosis J:62355
poikilocytosis J:162532
preweaning lethality, incomplete penetrance J:162532
reticulocytosis J:162532
schistocytosis J:162532
Ank1nb/Ank1nb
either: (involves: non-inbred stock) or (involves: C57BL/6) or (involves: WB/Re) 		abnormal bone marrow morphology J:30699
abnormal iron homeostasis J:30699
abnormal skin pigmentation J:30699
abnormal thymus development J:30699
cardiac hypertrophy J:30699
decreased body size J:30699
decreased erythrocyte cell number J:30699
decreased hematocrit J:30699
decreased hemoglobin content J:30699
enlarged liver J:30699
enlarged lymph nodes J:30699
enlarged spleen J:30699
gallstones J:6371
hypochromic anemia J:30699
impaired balance J:11441
increased leukocyte cell number J:30699
infertility J:30699
jaundice J:30699
Purkinje cell degeneration J:11441
tremors J:11441
Ank1nb/Ank1nb
involves: C57BL/6J * WB/Re 		abnormal erythrocyte morphology J:7501, J:42526, J:111131
abnormal erythrocyte physiology J:30033
abnormal iron homeostasis J:3122
abnormal kidney iron level J:3122
acanthocytosis J:111131
anisocytosis J:111131
anisopoikilocytosis J:111131
decreased susceptibility to parasitic infection J:111131
hemosiderosis J:3122
increased erythrocyte protoporphyrin level J:5985
increased liver iron level J:3122
low mean erythrocyte cell number J:3122
microcytic anemia J:3122
microcytosis J:111131
poikilocytosis J:111131
reticulocytosis J:3122, J:42526
spherocytosis J:3122
stomatocytosis J:111131
Ank1pale/Ank1pale
C57BL/6J-Ank1pale/GrsrJ 		abnormal skin pigmentation J:154215
decreased body size J:154215
postnatal lethality, complete penetrance J:154215
prenatal lethality, incomplete penetrance J:154215
Ank1Rbc2/Ank1+
involves: 129S1/Sv * BALB/c 		decreased mean corpuscular volume J:148127
decreased susceptibility to induced morbidity/mortality J:148127
decreased susceptibility to parasitic infection J:148127
increased erythrocyte osmotic fragility J:148127
Ank1Rbc2/Ank1Rbc2
involves: 129S1/Sv * BALB/c 		abnormal erythrocyte morphology J:148127
abnormal erythrocyte physiology J:148127
anemia J:148127
anisocytosis J:148127
decreased erythrocyte cell number J:148127
decreased hematocrit J:148127
decreased hemoglobin content J:148127
decreased mean corpuscular hemoglobin concentration J:148127
enlarged spleen J:148127
extramedullary hematopoiesis J:148127
increased circulating bilirubin level J:148127
increased erythrocyte osmotic fragility J:148127
increased hemoglobin concentration distribution width J:148127
increased liver iron level J:148127
increased nucleated erythrocyte cell number J:148127
jaundice J:148127
perinatal lethality, incomplete penetrance J:148127
poikilocytosis J:148127
postnatal lethality, incomplete penetrance J:148127
premature death J:148127
reticulocytosis J:148127
spherocytosis J:148127
Ank1tm1Vso/Ank1tm1Vso
B6J.129S4-Ank1tm1Vso 		abnormal calcium ion homeostasis J:223673
abnormal diaphragm morphology J:223673
abnormal extensor digitorum longus morphology J:223673
abnormal muscle electrophysiology J:223673
abnormal sarcolemma morphology J:223673
abnormal sarcoplasmic reticulum morphology J:223673
abnormal skeletal muscle fiber triad morphology J:223673
impaired exercise endurance J:223673
impaired skeletal muscle contractility J:223673
myopathy J:223673
skeletal muscle fiber degeneration J:223673
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory