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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ank2
ankyrin 2, brain
MGI:88025
63 phenotypes from 6 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ank2em1Bnt/Ank2+
C57BL/6J-Ank2em1Bnt 		abnormal axon morphology J:277752
normal behavior/neurological phenotype J:277752
enhanced spatial learning J:277752
Ank2em1Bnt/Ank2em1Bnt
C57BL/6J-Ank2em1Bnt 		abnormal axon morphology J:277752
abnormal brain morphology J:277752
abnormal excitatory synapse morphology J:277752
abnormal miniature excitatory postsynaptic currents J:277752
abnormal social/conspecific interaction behavior J:277752
normal behavior/neurological phenotype J:277752
decreased locomotor activity J:277752
decreased paired-pulse facilitation J:277752
decreased vocalization J:277752
enhanced spatial learning J:277752
increased grooming behavior J:277752
increased miniature excitatory postsynaptic current amplitude J:277752
increased miniature excitatory postsynaptic current frequency J:277752
normal taste/olfaction phenotype J:277752
Ank2em1Melr/Ank2em1Melr
B6.Cg-Ank2em1Melr 		abnormal heart echocardiography feature J:338515
abnormal myocardial fiber physiology J:338515
cardiac fibrosis J:338515
decreased cardiac muscle contractility J:338515
decreased heart rate J:338515
increased response of heart to induced stress J:338515
irregular heartbeat J:338515
prolonged QT interval J:338515
prolonged RR interval J:338515
sinus bradycardia J:338515
Ank2tm1Bnt/Ank2+
involves: 129 		abnormal fat cell differentiation J:222913
abnormal physiological response to xenobiotic J:163867
abnormal sinoatrial node conduction J:163867
decreased adipocyte glucose uptake J:222913
increased heart rate variability J:163867
Ank2tm1Bnt/Ank2tm1Bnt
B6.129-Ank2tm1Bnt/Bnt 		abnormal social/conspecific interaction behavior J:277752
decreased vocalization J:277752
enhanced spatial learning J:277752
Ank2tm1Bnt/Ank2tm1Bnt
involves: 129 		normal nervous system phenotype J:186168
Ank2tm1Bnt/Ank2tm1Bnt
involves: 129X1/SvJ * C57BL/6 		abnormal anterior corticospinal tract morphology J:52124
abnormal axon morphology J:52124
abnormal lateral corticospinal tract morphology J:52124
abnormal locomotor behavior J:52124
decreased body weight J:52124
decreased brain internal capsule size J:52124
decreased corpus callosum size J:52124
disorganized secondary lens fibers J:52124, J:70385
enlarged lateral ventricles J:52124
impaired balance J:52124
neonatal lethality, incomplete penetrance J:52124
optic nerve degeneration J:52124
postnatal lethality, complete penetrance J:52124
Ank2tm2.1Bnt/Ank2+
STOCK Ank2tm2Bnt/J 		impaired glucose tolerance J:222913
premature death J:222913
Ank2tm2.1Bnt/Ank2tm2.1Bnt
STOCK Ank2tm2Bnt/J 		abnormal fat cell differentiation J:222913
abnormal gluconeogenesis J:222913
normal behavior/neurological phenotype J:222913
normal homeostasis/metabolism phenotype J:222913
impaired glucose tolerance J:222913
increased adipocyte glucose uptake J:222913
increased body weight J:222913
increased circulating free fatty acids level J:222913
increased circulating glucose level J:222913
increased epididymal fat pad weight J:222913
increased fat cell size J:222913
increased susceptibility to age related obesity J:222913
increased susceptibility to diet-induced hepatic steatosis J:222913
increased susceptibility to diet-induced obesity J:222913
insulin resistance J:222913
normal muscle phenotype J:222913
Ank2tm3.1Bnt/Ank2+
B6.129(C)-Ank2tm3.1Bnt/J 		impaired glucose tolerance J:222913
increased circulating glucose level J:222913
increased susceptibility to age related obesity J:222913
premature death J:222913
Ank2tm3.1Bnt/Ank2tm3.1Bnt
B6.129(C)-Ank2tm3.1Bnt/J 		abnormal fat cell differentiation J:222913
abnormal gluconeogenesis J:222913
abnormal glucose homeostasis J:222913
normal behavior/neurological phenotype J:222913
decreased adipocyte glucose uptake J:222913
decreased circulating insulin level J:222913
decreased insulin secretion J:222913
decreased skeletal muscle cell glucose uptake J:222913
normal homeostasis/metabolism phenotype J:222913
impaired glucose tolerance J:222913
increased adipocyte glucose uptake J:222913
increased body weight J:222913
increased circulating free fatty acids level J:222913
increased circulating glucose level J:222913
increased epididymal fat pad weight J:222913
increased fat cell size J:222913
increased skeletal muscle cell glucose uptake J:222913
increased susceptibility to age related obesity J:222913
increased susceptibility to diet-induced hepatic steatosis J:222913
increased susceptibility to diet-induced obesity J:222913
increased total body fat amount J:222913
insulin resistance J:222913
Ank2tm4.1Bnt/Ank2+
Tg(Nes-cre)1Kln/0
B6.Cg-Ank2tm4.1Bnt Tg(Nes-cre)1Kln 		abnormal axon morphology J:277752
abnormal social/conspecific interaction behavior J:277752
decreased vocalization J:277752
enhanced spatial learning J:277752
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory