Ank3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ank3
ankyrin 3, epithelial
MGI:88026

28 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ank3^em1(IMPC)Bay/Ank3⁺ C57BL/6N-Ank3^em1(IMPC)Bay/BayMmucd	decreased grip strength	J:211773
Ank3^em1(IMPC)Bay/Ank3^em1(IMPC)Bay C57BL/6N-Ank3^em1(IMPC)Bay/BayMmucd	preweaning lethality, complete penetrance	J:211773
Ank3^tm1Bnt/Ank3^tm1Bnt involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal gait	J:51377
	ataxia	J:51377
	convulsive seizures	J:51377
	decreased locomotor activity	J:51377
	decreased Purkinje cell number	J:51377
	impaired ability to fire action potentials	J:51377
	premature death	J:51377
	Purkinje cell degeneration	J:51377
	small cerebellum	J:51377
	thin cerebellar molecular layer	J:51377
	tremors	J:51377
Ank3^tm2.1Bnt/Ank3^tm2.1Bnt Tg(Nes-cre)1Kln/? involves: 129X1/SvJ * C57BL/6 * SJL/J	abnormal axon morphology	J:218905
	perinatal lethality	J:218905
Ank3^tm2.2Bnt/Ank3^tm2.2Bnt involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N	abnormal bronchus epithelium morphology	J:198370
	abnormal kidney collecting duct epithelium morphology	J:198370
	postnatal lethality, complete penetrance	J:198370
	prenatal lethality, incomplete penetrance	J:198370
Ank3^tm3Bnt/Ank3^tm3Bnt Tg(Nes-cre)1Kln/? involves: 129S6/SvEvTac * C57BL/6 * SJL/J	abnormal action potential	J:218905
	abnormal axon initial segment morphology	J:218905
	abnormal axon morphology	J:218905
	abnormal brain wave pattern	J:218905
	abnormal hippocampus neuron morphology	J:218905
	abnormal nervous system electrophysiology	J:218905
	abnormal node of Ranvier morphology	J:218905
	abnormal paranodal axoglial junction morphology	J:218905
	abnormal Purkinje cell axon morphology	J:218905
	postnatal lethality	J:218905

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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