Aplp2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aplp2
amyloid beta precursor-like protein 2
MGI:88047

14 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Aplp1^tm1Umu/Aplp1^tm1Umu Aplp2^tm1Dbo/Aplp2^tm1Dbo involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J	perinatal lethality, complete penetrance	J:65196
Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.1Zhe/App^tm1.1Zhe Chat^tm2(cre)Lowl/Chat⁺ involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J	abnormal neuromuscular synapse morphology	J:152457
Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.1Zhe/App^tm1.1Zhe Tg(Ckmm-cre)5Khn/0 involves: 129S7/SvEvBrd * C57BL/6J * FVB	abnormal miniature endplate potential	J:152457
	abnormal neuromuscular synapse morphology	J:152457
Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.1Zhe/App^tm1.1Zhe Tg(Nes-cre)1Kln/0 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL	abnormal miniature endplate potential	J:152457
	abnormal neuromuscular synapse morphology	J:152457
Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm1.2Zhe involves: 129S7/SvEvBrd * C57BL/6J	abnormal neuromuscular synapse morphology	J:152457
Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.2Zhe/App^tm2.1Zhe involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	postnatal lethality, complete penetrance	J:165417
Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1Dbo/App^tm1Dbo involves: 129/Sv * 129X1/SvJ * C57BL/6	postnatal lethality, complete penetrance	J:166379
Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1Dbo/App^tm1Dbo involves: 129S7/SvEvBrd * C57BL/6J	abnormal neuromuscular synapse morphology	J:207796
	absent gastric milk in neonates	J:45851
	ataxia	J:45851
	decreased body size	J:45851
	head tilt	J:45851
	impaired righting response	J:45851
	pallor	J:45851
	postnatal lethality, incomplete penetrance	J:45851
	reduced fertility	J:45851
	spinning	J:45851
	weakness	J:45851
Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1Dbo/App^tm3.1Zhe involves: 129/Sv * 129X1/SvJ * C57BL/6	abnormal neuromuscular synapse morphology	J:166379
	postnatal lethality, incomplete penetrance	J:166379
Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm2.1Zhe/App^tm2.1Zhe involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	abnormal neuromuscular synapse morphology	J:165417
	postnatal lethality, complete penetrance	J:165417
Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm2Cwe/App^tm2Cwe involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J	postnatal lethality, complete penetrance	J:65196
Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm3.1Zhe/App^tm3.1Zhe involves: 129/Sv * 129X1/SvJ * C57BL/6	abnormal neuromuscular synapse morphology	J:166379
	postnatal lethality, incomplete penetrance	J:166379
Aplp2^tm1Dbo/Aplp2^tm1Dbo Lrp4^tm1Her/Lrp4^tm1Her involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J	abnormal neuromuscular synapse morphology	J:207796
	postnatal lethality, incomplete penetrance	J:207796

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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