Apoa1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Apoa1
apolipoprotein A-I
MGI:88049

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoa1^{tm1(APOA1)Prli}/Apoa1^{tm1(APOA1)Prli} involves: 129X1/SvJ * C57BL/6	normal homeostasis/metabolism phenotype	J:81908
Apoa1^{tm1(APOA1)Prli}/Apoa1^{tm2(APOA1)Prli} involves: 129X1/SvJ * C57BL/6J	abnormal liver physiology	J:81908
	decreased circulating cholesterol level	J:81908
Apoa1^tm1Bres/Apoa1^tm1Bres Apoa2^tm1Bres/Apoa2^tm1Bres involves: 129S4/SvJae * C57BL/6	decreased circulating HDL cholesterol level	J:40819
Apoa1^tm1Bres/Apoa1^tm1Bres Tg(Mt1-CETP)#Tall/0 involves: 129S4/SvJae * C57BL/6 * CBA/J	decreased circulating HDL cholesterol level	J:40819
Apoa1^tm1Unc/Apoa1^tm1Unc Ldlr^tm1Her/Ldlr^tm1Her B6.129-Ldlr^tm1Her Apoa1^tm1Unc	abnormal adrenal gland morphology	J:85174
	abnormal adrenal gland zona fasciculata morphology	J:85174
	abnormal liver morphology	J:85174
	decreased cholesterol level	J:85174
	decreased circulating cholesterol level	J:85174
	decreased circulating HDL cholesterol level	J:85174
	decreased circulating LDL cholesterol level	J:85174
	decreased circulating VLDL cholesterol level	J:85174
	decreased liver cholesterol level	J:85174
	increased circulating triglyceride level	J:85174
	increased pruritus	J:85174
	skin lesions	J:85174
	spontaneous skin ulceration	J:85174
	thick dermal layer	J:85174
	xanthoma	J:85174
Apoa1^tm1Unc/Apoa1^tm1Unc Tg(APOA1)1Rub/0 involves: 129P2/OlaHsd * C57BL/6	increased cholesterol efflux	J:129136
	increased circulating cholesterol level	J:129136
	increased circulating HDL cholesterol level	J:129136
	increased circulating triglyceride level	J:129136
Apoa1^tm1Unc/Apoa1^tm1Unc Tg(APOA2)3Rub/0 involves: 129P2/OlaHsd * C57BL/6	decreased circulating cholesterol level	J:129136
	increased circulating triglyceride level	J:129136
Apoa1^{tm2(APOA1)Prli}/Apoa1^{tm2(APOA1)Prli} involves: 129X1/SvJ * C57BL/6J	abnormal cholesterol homeostasis	J:81908
	abnormal liver physiology	J:81908
	decreased circulating cholesterol level	J:81908
	decreased circulating HDL cholesterol level	J:81908

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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