Apob Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Apob
apolipoprotein B
MGI:88052

29 phenotypes from 11 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Apob^tm1.1Zc/Apob⁺ involves: 129X1/SvJ * C57BL/6	decreased circulating LDL cholesterol level	J:65191
	decreased circulating VLDL cholesterol level	J:65191
	hepatic steatosis	J:65191
Apob^tm1.1Zc/Apob^tm1.1Zc involves: 129X1/SvJ * C57BL/6	decreased circulating HDL cholesterol level	J:65191
	decreased circulating LDL cholesterol level	J:65191
	decreased circulating triglyceride level	J:65191
	decreased circulating VLDL cholesterol level	J:65191
	hepatic steatosis	J:65191
	prenatal lethality, incomplete penetrance	J:65191
Apob^tm1Bres/Apob⁺ involves: 129S4/SvJae * C57BL/6J	asthenozoospermia	J:35836
	impaired sperm penetration of zona pellucida	J:35836
	oligozoospermia	J:35836
	reduced male fertility	J:35836
Apob^tm1Bres/Apob^tm1Bres involves: 129S4/SvJae * C57BL/6J	prenatal lethality, complete penetrance	J:29700
Apob^tm1Mae/Apob⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal circulating apolipoprotein level	J:36426, J:113171
	abnormal triglyceride level	J:113171
	decreased circulating cholesterol level	J:113171
	hydrocephaly	J:36426
Apob^tm1Mae/Apob^tm1Mae involves: 129P2/OlaHsd * C57BL/6J	abnormal circulating apolipoprotein level	J:36426
	abnormal circulating HDL cholesterol level	J:36426
	decreased circulating cholesterol level	J:36426
	decreased circulating LDL cholesterol level	J:36426
	decreased circulating VLDL cholesterol level	J:36426
	exencephaly	J:36426
	hydrocephaly	J:36426
Apob^tm1Meh/Apob⁺ involves: 129P2/OlaHsd * C57BL/6NCrl	normal homeostasis/metabolism phenotype	J:99059
Apob^tm1Meh/Apob^tm1Meh involves: 129P2/OlaHsd * C57BL/6NCrl	normal homeostasis/metabolism phenotype	J:99059
Apob^tm1Sgy/Apob^tm1Sgy involves: 129/Sv * C57BL/6	decreased circulating LDL cholesterol level	J:33830
Apob^tm1Sgy/Apob^tm1Sgy involves: 129/Sv * C57BL/6	decreased circulating triglyceride level	J:33830
Apob^tm1Unc/Apob⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal circulating cholesterol level	J:16352
	decreased circulating HDL cholesterol level	J:16352
	decreased circulating triglyceride level	J:16352
Apob^tm1Unc/Apob^tm1Unc involves: 129P2/OlaHsd * C57BL/6J	abnormal circulating cholesterol level	J:16352
	decreased circulating HDL cholesterol level	J:16352
	decreased circulating triglyceride level	J:16352
	exencephaly	J:16352, J:24237
	hydrocephaly	J:16352, J:24237
Apob^tm1Zc/Apob⁺ involves: 129/Sv * C57BL/6	decreased circulating cholesterol level	J:76047
	decreased circulating HDL cholesterol level	J:76047
	decreased circulating LDL cholesterol level	J:76047
	decreased circulating triglyceride level	J:76047
	decreased circulating VLDL cholesterol level	J:76047
	hepatic steatosis	J:76047
Apob^tm1Zc/Apob^tm1.1Zc involves: 129/Sv * C57BL/6	decreased circulating cholesterol level	J:76047
	decreased circulating HDL cholesterol level	J:76047
	decreased circulating LDL cholesterol level	J:76047
	decreased circulating triglyceride level	J:76047
	decreased circulating VLDL cholesterol level	J:76047
	hepatic steatosis	J:76047
Apob^tm1Zc/Apob^tm1Zc involves: 129/Sv * C57BL/6	decreased circulating cholesterol level	J:76047
	decreased circulating triglyceride level	J:76047
	hepatic steatosis	J:76047
	prenatal lethality, incomplete penetrance	J:76047
Apob^tm2Sgy/Apob^tm2Sgy involves: 129/Sv * C57BL/6	increased circulating LDL cholesterol level	J:33830
Apob^tm2Sgy/Apob^tm2Sgy involves: 129/Sv * C57BL/6	increased circulating triglyceride level	J:33830
Apob^tm2Sgy/Apob^tm4Sgy involves: 129/Sv * 129S4/SvJae * C57BL/6	decreased circulating cholesterol level	J:46549
Apob^tm3Sgy/Apob⁺ involves: 129S7/SvEvBrd * C57BL/6	abnormal cholesterol homeostasis	J:23315
	abnormal embryo development	J:84977
	abnormal visceral yolk sac endoderm morphology	J:84977
	decreased circulating cholesterol level	J:23315
	decreased circulating HDL cholesterol level	J:23315
Apob^tm3Sgy/Apob^tm3Sgy involves: 129S7/SvEvBrd * C57BL/6	abnormal embryo development	J:84977
	abnormal visceral yolk sac endoderm morphology	J:84977
	embryonic lethality during organogenesis, incomplete penetrance	J:23315
	exencephaly	J:23315
Apob^tm4Sgy/Apob^tm4Sgy involves: 129S4/SvJae * C57BL/6	decreased embryo size	J:46549
	exencephaly	J:46549
	hemorrhage	J:46549
	herniated liver	J:46549
	prenatal lethality, complete penetrance	J:46549
Apob^tm5Sgy/Apob^tm5Sgy involves: 129S4/SvJae * C57BL/6	decreased circulating LDL cholesterol level	J:51549
	decreased circulating VLDL cholesterol level	J:51549
	postnatal lethality	J:51549

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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