Apob Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Apob
apolipoprotein B
MGI:88052

40 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apob^tm1Sgy/Apob^tm1Sgy Apoe^tm1Unc/Apoe^tm1Unc involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	increased body weight	J:41510
	increased circulating cholesterol level	J:41510
	increased circulating triglyceride level	J:41510
	increased circulating VLDL cholesterol level	J:41510
	increased susceptibility to atherosclerosis	J:41510
Apob^tm2Sgy/Apob^tm2Sgy Apoe^tm1Unc/Apoe^tm1Unc involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	abnormal cholesterol homeostasis	J:41510
	decreased body weight	J:41510
	decreased circulating cholesterol level	J:41510
	decreased susceptibility to atherosclerosis	J:41510
	increased circulating HDL cholesterol level	J:41510
	increased circulating triglyceride level	J:41510
	increased circulating VLDL cholesterol level	J:41510
	increased circulating VLDL triglyceride level	J:41510
Apob^tm2Sgy/Apob^tm2Sgy Apoe^tm1Unc/Apoe^tm1Unc Lep^ob/Lep^ob involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	abnormal circulating cholesterol level	J:133453
	atherosclerotic lesions	J:133453
	decreased circulating HDL cholesterol level	J:133453
	hyperglycemia	J:133453
	hypertension	J:133453
	impaired glucose tolerance	J:133453
	increased circulating cholesterol level	J:133453
	increased circulating free fatty acids level	J:133453
	increased circulating insulin level	J:133453
	increased circulating triglyceride level	J:133453
	increased circulating VLDL cholesterol level	J:133453
	obese	J:133453
Apob^tm2Sgy/Apob^tm2Sgy Ldlr^tm1Her/Ldlr^tm1Her involves: 129S7/SvEvBrd * C57BL/6	abnormal eye electrophysiology	J:136142
	abnormal retina pigment epithelium morphology	J:136142
Apob^tm2Sgy/Apob^tm2Sgy Ldlr^tm1Her/Ldlr^tm1Her involves: 129S7/SvEvBrd * C57BL/6J	abnormal aorta bulb morphology	J:227165
	abnormal heart ventricles weight	J:227165
	aortic valve stenosis	J:227165
	decreased cardiac muscle contractility	J:227165
	increased cardiac output	J:227165
	increased cardiac stroke volume	J:227165
	increased circulating cholesterol level	J:227165
	increased circulating insulin level	J:227165
Apob^tm2Sgy/Apob^tm2Sgy Ldlr^tm1Her/Ldlr^tm1Her Lep^ob/Lep^ob involves: 129S7/SvEvBrd * C57BL/6	abnormal circulating cholesterol level	J:133453
	atherosclerotic lesions	J:133453
	decreased circulating HDL cholesterol level	J:133453
	hypertension	J:133453
	increased circulating cholesterol level	J:133453
	increased circulating free fatty acids level	J:133453
	increased circulating insulin level	J:133453
	increased circulating LDL cholesterol level	J:133453
	increased circulating triglyceride level	J:133453
	obese	J:133453
Apob^tm2Sgy/Apob^tm2Sgy Ldlr^tm1Her/Ldlr^tm1Her Tg(Ins-Igf2)1Fbos/? involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL	abnormal aorta bulb morphology	J:227165
	abnormal aortic valve morphology	J:227165
	abnormal cardiovascular system physiology	J:227165
	abnormal fasting circulating glucose level	J:227165
	abnormal heart left ventricle morphology	J:227165
	abnormal heart ventricles weight	J:227165
	aortic valve stenosis	J:227165
	aortitis	J:227165
	calcified aortic valve	J:227165
	cardiac fibrosis	J:227165
	cardiac hypertrophy	J:227165
	decreased cardiac muscle contractility	J:227165
	heart left ventricle hypertrophy	J:227165
	increased cardiac output	J:227165
	increased cardiac stroke volume	J:227165
	increased circulating cholesterol level	J:227165
	increased circulating insulin level	J:227165
	small aortic valve	J:227165
Apob^tm2Sgy/Apob^tm2Sgy Ldlr^tm1Her/Ldlr^tm1Her Tg(Ins-Igf2)1Fbos/? involves: 129S7/SvEvBrd * C57BL/6 * SJL	atherosclerotic lesions	J:141333
	impaired glucose tolerance	J:141333
	increased circulating glucose level	J:141333
	increased circulating insulin level	J:141333

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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