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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		App
amyloid beta precursor protein
MGI:88059
100 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Agrntm1Rwb/Agrntm1Rwb
Tg(APPswe,PSEN1dE9)85Dbo/?
Tg(Tek-cre)1Ywa/?
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL 		amyloid beta deposits J:220073
Agrntm5Jrs/Agrntm5Jrs
Tg(APPswe,PSEN1dE9)85Dbo/?
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * FVB/N 		normal nervous system phenotype J:220073
Aplp1tm1Umu/Aplp1tm1Umu
Apptm2Cwe/Apptm2Cwe
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		decreased body weight J:65196
Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1.1Zhe/Apptm1.1Zhe
Chattm2(cre)Lowl/Chat+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J 		abnormal neuromuscular synapse morphology J:152457
Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1.1Zhe/Apptm1.1Zhe
Tg(Ckmm-cre)5Khn/0
involves: 129S7/SvEvBrd * C57BL/6J * FVB 		abnormal miniature endplate potential J:152457
abnormal neuromuscular synapse morphology J:152457
Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1.1Zhe/Apptm1.1Zhe
Tg(Nes-cre)1Kln/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL 		abnormal miniature endplate potential J:152457
abnormal neuromuscular synapse morphology J:152457
Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1.2Zhe/Apptm1.2Zhe
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal neuromuscular synapse morphology J:152457
Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1.2Zhe/Apptm2.1Zhe
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		postnatal lethality, complete penetrance J:165417
Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1Dbo/Apptm1Dbo
involves: 129/Sv * 129X1/SvJ * C57BL/6 		postnatal lethality, complete penetrance J:166379
Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1Dbo/Apptm1Dbo
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal neuromuscular synapse morphology J:207796
absent gastric milk in neonates J:45851
ataxia J:45851
decreased body size J:45851
head tilt J:45851
impaired righting response J:45851
pallor J:45851
postnatal lethality, incomplete penetrance J:45851
reduced fertility J:45851
spinning J:45851
weakness J:45851
Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm1Dbo/Apptm3.1Zhe
involves: 129/Sv * 129X1/SvJ * C57BL/6 		abnormal neuromuscular synapse morphology J:166379
postnatal lethality, incomplete penetrance J:166379
Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm2.1Zhe/Apptm2.1Zhe
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		abnormal neuromuscular synapse morphology J:165417
postnatal lethality, complete penetrance J:165417
Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm2Cwe/Apptm2Cwe
involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J 		postnatal lethality, complete penetrance J:65196
Aplp2tm1Dbo/Aplp2tm1Dbo
Apptm3.1Zhe/Apptm3.1Zhe
involves: 129/Sv * 129X1/SvJ * C57BL/6 		abnormal neuromuscular synapse morphology J:166379
postnatal lethality, incomplete penetrance J:166379
Apmaptm1a(KOMP)Wtsi/Apmaptm1a(KOMP)Wtsi
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: C57BL/6J * C57BL/6N 		abnormal spatial reference memory J:273177
amyloid beta deposits J:273177
Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf
involves: 129S1/Sv * 129X1/SvJ * CD-1 		amyloid beta deposits J:66147, J:102425
Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm
involves: 129 * 129S1/Sv * 129X1/SvJ 		abnormal brain morphology J:191170
abnormal spatial working memory J:191170
amyloid beta deposits J:166379
enhanced contextual conditioning behavior J:191170
increased anxiety-related response J:191170
increased circulating corticosterone level J:191170
Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm
Tg(MAPT)8cPdav/0
B6.Cg-Tg(MAPT)8cPdav Psen1tm1Mpm Apptm1Ck 		amyloid beta deposits J:209782
decreased locomotor activity J:209782
enhanced contextual conditioning behavior J:209782
increased anxiety-related response J:209782
increased fear-related response J:209782
tau protein deposits J:209782
Apptm1Ck/Apptm1Ck
Tg(PDGFB-PSEN1)1Jhd/0
involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW 		abnormal cholinergic neuron morphology J:102542
Apptm1Ck/Apptm1Ck
Tg(PDGFB-PSEN1M146L)2Jhd/0
involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW 		abnormal cholinergic neuron morphology J:102542, J:102879
abnormal microglial cell morphology J:102542
amyloid beta deposits J:102542, J:102879
increased astrocyte number J:102542
Apptm1Dbo/App+
Lrp4tm1Her/Lrp4tm1Her
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J 		premature death J:207796
Apptm1Dbo/App+
Dab1tm1Bwh/Dab1tm1Bwh
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 		small cerebellum J:132599
Apptm1Dbo/Apptm1Dbo
Dab1tm1Bwh/Dab1tm1Bwh
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 		small cerebellum J:132599
Apptm1Dbo/Apptm1Dbo
Lrp4tm1Her/Lrp4+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J 		premature death J:207796
Apptm1Dbo/Apptm1Dbo
Lrp4tm1Her/Lrp4tm1Her
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J 		abnormal neuromuscular synapse morphology J:207796
abnormal neuron differentiation J:207796
preweaning lethality, incomplete penetrance J:207796
Apptm1Dbo/Apptm1Dbo
Npc1m1N/Npc1m1N
C.Cg-Apptm1Dbo Npc1m1N 		astrocytosis J:172769
decreased brain size J:172769
demyelination J:172769
impaired coordination J:172769
increased brain cholesterol level J:172769
premature death J:172769
Purkinje cell degeneration J:172769
weight loss J:172769
Apptm1Sud/Apptm1Sud
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:133653
Apptm1Umu/Apptm1Umu
involves: 129P2/OlaHsd * C57BL/6 		normal behavior/neurological phenotype J:123316
normal growth/size/body region phenotype J:123316
normal nervous system phenotype J:123316
Apptm2.1Tcs/Apptm2.1Tcs
Casttm1Tcs/Casttm1Tcs
involves: 129P2/OlaHsd * C57BL/6 		abnormal learning/memory/conditioning J:212758
amyloid beta deposits J:212758
amyloidosis J:212758
astrocytosis J:212758
microgliosis J:212758
Apptm3.1Tcs/Apptm3.1Tcs
Klk7tm1(KOMP)Vlcg/Klk7tm1(KOMP)Vlcg
involves: C57BL/6NTac 		amyloid beta deposits J:261970
Apptm3.1Tcs/Apptm3.1Tcs
Mapttm1.1(MAPT)Tcs/Mapttm1.1(MAPT)Tcs
involves: 129S/SvEv * C57BL/6 		amyloid beta deposits J:278451
CNS inflammation J:278451
increased neuron apoptosis J:278451
Apptm3.1Zhe/Apptm3.1Zhe
Psen1tm1Mpm/Psen1tm1Mpm
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		amyloid beta deposits J:166379
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pion)Pggd/Gt(ROSA)26Sor+
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129S6/SvEvTac * C3H * C57BL/6 		amyloid beta deposits J:163997
Hc1/Hc1
Tg(APPswe,PSEN1dE9)85Dbo/0
D2.Cg-Tg(APPswe,PSEN1dE9)85Dbo 		amyloid beta deposits J:227541
convulsive seizures J:227541
normal nervous system phenotype J:227541
premature death J:227541
Itm2btm1.1Ldad/Itm2b+
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129 * C3H * C57BL/6 		abnormal nervous system physiology J:138796
Leprdb/Lepr+
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: C3H * C57BL/6 * C57BLKS/J 		abnormal circulating cholesterol level J:186924
amyloidosis J:186924
normal growth/size/body region phenotype J:186924
impaired glucose tolerance J:186924
increased circulating glucose level J:186924
increased circulating insulin level J:186924
increased pancreatic beta cell mass J:186924
insulin resistance J:186924
Lrrtm3tm1Msa/Lrrtm3tm1Msa
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6JHsd 		normal homeostasis/metabolism phenotype J:262456
Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(APPswe,PSEN1dE9)85Dbo/0
Tg(Camk2a-cre/ERT2)2Gsc/0
involves: C3H * C57BL/6 * FVB/N 		abnormal neurite morphology J:178060
amyloid beta deposits J:178060
Nr1h2tm1Djm/Nr1h2tm1Djm
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129S6/SvEvTac * C3H * C57BL/6 		amyloid beta deposits J:122372
Nr1h3tm1Djm/Nr1h3tm1Djm
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129S6/SvEvTac * C3H * C57BL/6 		amyloid beta deposits J:122372
Omptm1(tTA)Gogo/Omp+
Tg(tetO-APPSwInd)Dbo/0
involves: 129 * C3H/HeJ * C57BL/6J 		abnormal olfactory bulb glomerular layer morphology J:199798
abnormal olfactory bulb morphology J:199798
abnormal olfactory bulb outer nerve layer morphology J:199798
abnormal olfactory epithelium morphology J:176127
abnormal olfactory sensory neuron morphology J:199798
abnormal olfactory sensory neuron physiology J:176127
abnormal synaptic bouton morphology J:199798
decreased olfactory sensory neuron number J:176127
impaired olfaction J:199798
neurodegeneration J:176127
small olfactory bulb J:199798
Omptm1(tTA)Gogo/Omptm2(spH)Mom
Tg(tetO-APPSwInd)Dbo/0
involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J 		impaired olfaction J:199798
Or8a1tm25Mom/Or8a1+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-APPSwInd)Dbo/0
involves: 129 * C3H/HeJ * C57BL/6J 		decreased olfactory sensory neuron number J:199798
Or10a4tm1Mom/Or10a4+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-APPSwInd)Dbo/0
involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J 		abnormal olfactory bulb layer morphology J:199798
decreased olfactory sensory neuron number J:199798
Prnptm2Edin/Prnptm2Edin
Tg(APPswe,PSEN1dE9)85Dbo/0
B6.Cg-Prnptm2Edin Tg(APPswe,PSEN1dE9)85Dbo 		amyloid beta deposits J:160557
astrocytosis J:160557
normal behavior/neurological phenotype J:160557
normal mortality/aging J:160557
normal nervous system phenotype J:160557
Ptger2tm1Brey/Ptger2tm1Brey
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129S6/SvEvTac * C3H * C57BL/6 		abnormal nervous system physiology J:102728
amyloidosis J:102728
Rtn3tm1Yanr/Rtn3tm1Yanr
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129S6/SvEvTac * C3H * C57BL/6 		amyloid beta deposits J:217161
Rtn4rl2tm1Yanr/Rtn4rl2tm1Yanr
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J 		amyloid beta deposits J:175718
Tg(APPswe,PSEN1dE9)85Dbo/0
B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax 		abnormal CNS synaptic transmission J:234430
abnormal spatial learning J:160557, J:172426
amyloid beta deposits J:160557, J:172426, J:208080, J:227541
astrocytosis J:160557
axon degeneration J:160557
convulsive seizures J:227541
impaired contextual conditioning behavior J:234430
impaired passive avoidance behavior J:160557
impaired spatial learning J:234430
premature death J:160557
reduced long-term potentiation J:234430
normal taste/olfaction phenotype J:172426
Tg(APPswe,PSEN1dE9)85Dbo/0
B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax 		abnormal spatial learning J:129021
amyloid beta deposits J:113199, J:113200, J:129021
amyloidosis J:129021
blood vessel congestion J:113200
cerebral amyloid angiopathy J:113200
impaired glucose tolerance J:129021
increased body weight J:129021
increased circulating cholesterol level J:129021
increased circulating insulin level J:129021
increased circulating triglyceride level J:113199
increased fluid intake J:129021
Tg(APPswe,PSEN1dE9)85Dbo/0
CAST.Cg-Tg(APPswe,PSEN1dE9)85Dbo/How 		cerebral amyloid angiopathy J:276728
Tg(APPswe,PSEN1dE9)85Dbo/0
D2.Cg-Tg(APPswe,PSEN1dE9)85Dbo 		amyloid beta deposits J:227541
convulsive seizures J:227541
microgliosis J:227541
normal nervous system phenotype J:227541
premature death J:227541
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: C3H * C57BL/6 		abnormal medium spiny neuron morphology J:145530
amyloidosis J:186924
decreased neuron number J:145530
normal homeostasis/metabolism phenotype J:186924
normal nervous system phenotype J:145530
neuron degeneration J:145530
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: C3H/HeH * C57BL/6JNju 		abnormal action potential J:275175
abnormal asymmetric synapse morphology J:275175
abnormal olfactory behavior J:275175
abnormal olfactory bulb external plexiform layer morphology J:275175
abnormal olfactory bulb granule cell morphology J:275175
abnormal postsynaptic density morphology J:275175
abnormal spatial reference memory J:275175
abnormal symmetric synapse morphology J:275175
abnormal synapse morphology J:275175
abnormal synaptic transmission J:275175
abnormal synaptic vesicle morphology J:275175
amyloid beta deposits J:275175
decreased dendritic spine density J:275175
impaired spatial learning J:275175
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: C3H/HeJ * C57BL/6J 		abnormal spatial reference memory J:139071
amyloid beta deposits J:87691, J:139071
decreased body weight J:139071
impaired coordination J:139071
reduced long-term potentiation J:139071
Tg(APPswe,PSEN1dE9)85Dbo/0
WSB.Cg-Tg(APPswe,PSEN1dE9)85Dbo/How 		cerebral amyloid angiopathy J:276728
impaired blood-brain barrier function J:276728
Tg(APPswe,PSEN1dE9)85Dbo/?
Tg(MGS1-19375/CFP)2R9Rwb/?
involves: C3H * C57BL/6 * C57BL/6J 		amyloid beta deposits J:220073
Tg(Camk2a-App*,-Apbb1)25Spim/0
C57BL/6-Tg(Camk2a-App*,-Apbb1)25Spim 		abnormal spatial working memory J:153738
normal behavior/neurological phenotype J:153738
increased susceptibility to neuronal excitotoxicity J:153738
neurodegeneration J:153738
tau protein deposits J:153738
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory