About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atf4
activating transcription factor 4
MGI:88096
72 phenotypes from 9 alleles in 12 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Atf4tm1(KOMP)Mbp/Atf4+
C57BL/6NCrl-Atf4tm1(KOMP)Mbp/MbpMmucd 		decreased monocyte cell number J:211773
decreased prepulse inhibition J:211773
increased circulating alanine transaminase level J:211773
increased circulating aspartate transaminase level J:211773
increased mean corpuscular hemoglobin J:211773
Atf4tm1(KOMP)Mbp/Atf4tm1(KOMP)Mbp
C57BL/6NCrl-Atf4tm1(KOMP)Mbp/MbpMmucd 		preweaning lethality, complete penetrance J:211773
Atf4tm1.1Cmad/Atf4tm1.1Cmad
Tg(Ckmm-cre)5Khn/0
involves: C57BL/6 * FVB 		decreased susceptibility to induced muscular atrophy J:206503
normal muscle phenotype J:206503
Atf4tm1.1Cmad/Atf4tm1.1Cmad
Tg(Myh11-icre/ERT2)1Soff/?
D2.Cg-Atf4tm1.1Cmad Tg(Myh11-icre/ERT2)1Soff 		abnormal aorta morphology J:237331
abnormal calcium ion homeostasis J:237331
normal homeostasis/metabolism phenotype J:237331
Atf4tm1Aki/Atf4tm1Aki
involves: 129P2/OlaHsd 		abnormal lens fiber morphology J:56007
abnormal vas deferens morphology J:96728
increased lens epithelium apoptosis J:56007
microphthalmia J:56007
postnatal lethality, incomplete penetrance J:56007
reduced male fertility J:96728
Atf4tm1Aki/Atf4tm1Aki
Tg(Cryaa-Atf4)4Aki/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal lens fiber morphology J:56007
Atf4tm1Jml/Atf4tm1Jml
involves: 129X1/SvJ 		abnormal ciliary body morphology J:62578
abnormal iris morphology J:62578
aphakia J:62578
decreased body size J:62578
decreased fetal size J:62578
eyelids fail to open J:62578
microphthalmia J:62578
perinatal lethality, incomplete penetrance J:62578
Atf4tm1Kry/Atf4tm1Kry
Tg(Col1a1-cre)1Kry/0
involves: C57BL/6J * FVB 		abnormal glucose homeostasis J:152695
abnormal glycogen homeostasis J:152695
decreased body weight J:152695
decreased circulating glucose level J:152695
normal homeostasis/metabolism phenotype J:152695
impaired gluconeogenesis J:152695
improved glucose tolerance J:152695
increased insulin secretion J:152695
increased insulin sensitivity J:152695
Atf4tm1Tow/Atf4tm1Tow
either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss) 		decreased circulating glucose level J:152695
decreased total fat pad weight J:152695
impaired gluconeogenesis J:152695
improved glucose tolerance J:152695
increased circulating insulin level J:152695
increased insulin secretion J:152695
increased insulin sensitivity J:152695
increased pancreatic beta cell mass J:152695
increased pancreatic beta cell proliferation J:152695
Atf4tm1Tow/Atf4tm1Tow
either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss) 		abnormal bone mineralization J:89403
abnormal bone ossification J:89403
abnormal bone trabecula morphology J:89403
abnormal clavicle morphology J:89403
abnormal frontal bone morphology J:89403
abnormal neurocranium morphology J:89403
abnormal osteoblast differentiation J:129974
abnormal pancreas morphology J:129974
abnormal pancreatic acinar cell morphology J:129974
abnormal pancreatic acinar cell zymogen granule morphology J:129974
abnormal pancreatic acinus morphology J:129974
abnormal parietal bone morphology J:89403
decreased bone mineral density J:89403
exocrine pancreas hypoplasia J:89403
large fontanelles J:89403
Atf4tm1Tow/Atf4tm1Tow
involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss 		absent common myeloid progenitor cells J:74479
anemia J:74479
decreased body length J:74479
decreased body weight J:74479
decreased cell proliferation J:74479
decreased hematocrit J:74479
decreased hepatocyte number J:74479
delayed hair appearance J:74479
female infertility J:74479
impaired hematopoiesis J:74479
male infertility J:74479
microphthalmia J:74479
pale liver J:74479
perinatal lethality, incomplete penetrance J:74479
postnatal growth retardation J:74479
postnatal lethality, incomplete penetrance J:74479
reduced male fertility J:74479
ruffled hair J:74479
Tg(CMV-Atf4)1Kry/0
involves: C57BL/6J 		normal endocrine/exocrine gland phenotype J:152695
normal homeostasis/metabolism phenotype J:152695
Tg(Col1a1-Atf4)1Kry/0
involves: FVB 		abnormal circulating glucose level J:152695
decreased circulating insulin level J:152695
decreased insulin secretion J:152695
decreased pancreatic beta cell proliferation J:152695
normal homeostasis/metabolism phenotype J:152695
impaired glucose tolerance J:152695
increased circulating glucose level J:152695
increased physiological sensitivity to xenobiotic J:152695
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory