Atp1a1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
MGI:88105

24 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atp1a1^{em1(IMPC)Ccpcz}/Atp1a1⁺ C57BL/6NCrl-Atp1a1^{em1(IMPC)Ccpcz}/Ccpcz	abnormal digit morphology	J:211773
	abnormal heart morphology	J:211773
	abnormal lymph node morphology	J:211773
	abnormal skeletal muscle morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	abnormal uterus morphology	J:211773
	decreased heart rate	J:211773
	enlarged heart	J:211773
	enlarged lymph nodes	J:211773
	enlarged thymus	J:211773
	increased heart left ventricle size	J:211773
	thick ventricular wall	J:211773
Atp1a1^{em1(IMPC)Ccpcz}/Atp1a1^{em1(IMPC)Ccpcz} C57BL/6NCrl-Atp1a1^{em1(IMPC)Ccpcz}/Ccpcz	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Atp1a1^{Gt(OST31117)Lex}/Atp1a1⁺ involves: 129S5/SvEvBrd * C57BL/6J	decreased exploration in new environment	J:103485
	increased anxiety-related response	J:103485
Atp1a1^{Gt(OST31117)Lex}/Atp1a1^{Gt(OST31117)Lex} involves: 129S5/SvEvBrd * C57BL/6J	preweaning lethality, complete penetrance	J:103485
Atp1a1^tm1Ling/Atp1a1⁺ involves: 129P2/OlaHsd	impaired muscle contractility	J:114415
Atp1a1^tm1Ling/Atp1a1⁺ involves: 129P2/OlaHsd * Black Swiss	abnormal locomotor activation	J:117414
	enhanced behavioral response to addictive substance	J:117414
	increased circulating corticosterone level	J:117414
Atp1a1^tm1Ling/Atp1a1⁺ involves: 129P2/OlaHsd * C57BL/6 * Black Swiss	decreased cardiac muscle contractility	J:55191
Atp1a1^tm1Ling/Atp1a1^tm1Ling involves: 129P2/OlaHsd * C57BL/6 * Black Swiss	preweaning lethality, complete penetrance	J:55191

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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