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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
MGI:88107
73 phenotypes from 8 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atp1a3Myk/Atp1a3+
B6NCr.129S1-Atp1a3Myk 		abnormal behavior J:180250, J:262367
abnormal enzyme/coenzyme activity J:180250
abnormal gait J:180250
abnormal habituation J:180250
abnormal hippocampus pyramidal cell morphology J:151948
abnormal neuron physiology J:180250
abnormal non-rapid eye movement sleep pattern J:180250
abnormal paradoxical sleep pattern J:180250
abnormal response to novel object J:180250
abnormal seizure response to inducing agent J:180250
abnormal sensitization to xenobiotic J:180250
abnormal sensorimotor gating J:180250
abnormal sleep pattern J:180250
abnormal spike wave discharge J:151948
abnormal startle reflex J:180250
abnormal temporal lobe morphology J:151948
convulsive seizures J:151948
decreased anxiety-related response J:180250
decreased body size J:151948
decreased body weight J:151948, J:262367
decreased frequency of paradoxical sleep J:180250
decreased prepulse inhibition J:180250
enhanced conditioned place preference behavior J:180250
environmentally induced seizures J:151948
impaired contextual conditioning behavior J:262367
impaired coordination J:262367
increased locomotor activity J:180250
increased thigmotaxis J:262367
normal nervous system phenotype J:151948
premature death J:151948
prolonged circadian behavior period J:180250
Atp1a3Myk/Atp1a3+
involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr 		abnormal hippocampus pyramidal cell morphology J:151948
abnormal spike wave discharge J:151948
abnormal temporal lobe morphology J:151948
convulsive seizures J:151948
decreased body size J:151948
decreased body weight J:151948
environmentally induced seizures J:151948
normal nervous system phenotype J:151948
premature death J:151948
Atp1a3Myk/Atp1a3+
involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr * FVB/NCr 		astrocytosis J:151948
microgliosis J:151948
Atp1a3Myk/Atp1a3+
Tg(Atp1a3)1Stcl/0
B6NCr.Cg-Atp1a3Myk Tg(Atp1a3)1Stcl 		abnormal behavior J:262367
normal behavior/neurological phenotype J:262367
normal growth/size/body region phenotype J:262367
increased thigmotaxis J:262367
Atp1a3Myk/Atp1a3+
Tg(Atp1a3)1Stcl/0
involves: 129S1/SvImJ * C57BL/6 * SJL 		normal behavior/neurological phenotype J:180250
normal nervous system phenotype J:151948
Atp1a3Myk/Atp1a3Myk
involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr 		neonatal lethality, complete penetrance J:151948
Atp1a3Myk/Atp1a3tm1Ling
involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr 		premature death J:151948
Atp1a3tm1.1Kwk/Atp1a3+
B6JJcl.Cg-Atp1a3tm1.1Kwk/Kwk 		abnormal CNS synaptic transmission J:210870
abnormal xenobiotic pharmacokinetics J:210870
dystonia J:210870
enhanced coordination J:210870
hyperactivity J:210870
increased miniature inhibitory postsynaptic current frequency J:210870
normal nervous system phenotype J:210870
Atp1a3tm1.1Kwk/Atp1a3tm1.1Kwk
B6JJcl.Cg-Atp1a3tm1.1Kwk/Kwk 		abnormal respiratory function J:210870
neonatal lethality, complete penetrance J:210870
Atp1a3tm1.1Tmklh/Atp1a3+
B6JRj.129S1-Atp1a3tm1.1Tmklh 		abnormal action potential J:254463
abnormal behavior J:254463
abnormal dentate gyrus morphology J:254463
abnormal habituation to a new environment J:254463
abnormal hippocampus granule cell morphology J:254463
normal behavior/neurological phenotype J:254463
hyperactivity J:254463
impaired passive avoidance behavior J:254463
impaired spatial learning J:254463
increased susceptibility to pharmacologically induced seizures J:254463
increased susceptibility to xenobiotic induced morbidity/mortality J:254463
normal nervous system phenotype J:254463
preweaning lethality, incomplete penetrance J:254463
Atp1a3tm1.1Tmklh/Atp1a3tm1.1Tmklh
B6JRj.129S1-Atp1a3tm1.1Tmklh 		neonatal lethality, complete penetrance J:254463
Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H 		abnormal locomotor behavior J:211773
decreased anxiety-related response J:211773
hyperactivity J:211773
improved glucose tolerance J:211773
increased exploration in new environment J:211773
Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3tm1b(EUCOMM)Hmgu
C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H 		preweaning lethality, complete penetrance J:211773
Atp1a3tm1Ling/Atp1a3+
involves: 129 * Black Swiss 		abnormal spatial learning J:117414
enhanced behavioral response to addictive substance J:117414
normal homeostasis/metabolism phenotype J:117414
hyperactivity J:117414
Atp1a3tm1Ling/Atp1a3tm1Ling
involves: 129 * Black Swiss 		neonatal lethality, complete penetrance J:117414
Atp1a3tm1Mika/Atp1a3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal gait J:264408
abnormal long-term object recognition memory J:264408
abnormal motor capabilities/coordination/movement J:264408
abnormal response to novel object J:264408
abnormal seizure response to inducing agent J:264408
decreased body size J:264408
decreased body weight J:264408
decreased exploration in new environment J:264408
decreased locomotor activity J:264408
dystonia J:264408
hemiplegia J:264408
impaired coordination J:264408
increased kindling response J:264408
limb grasping J:264408
premature death J:264408
seizures J:264408
short stride length J:264408
Atp1a3tm1Ute/Atp1a3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal behavior J:262419
abnormal CNS synaptic transmission J:262419
abnormal long-term object recognition memory J:262419
ataxia J:262419
normal behavior/neurological phenotype J:262419
decreased anxiety-related response J:262419
decreased body weight J:262419
dystonia J:262419
normal growth/size/body region phenotype J:262419
hemiparesis J:262419
hemiplegia J:262419
hyperactivity J:262419
impaired coordination J:262419
increased kindling response J:262419
increased susceptibility to pharmacologically induced seizures J:262419
increased thermal nociceptive threshold J:262419
limb grasping J:262419
premature death J:262419
seizures J:262419
short stride length J:262419
tremors J:262419
Tg(Atp1a3)1Stcl/0
B6NCr.Cg-Tg(Atp1a3)1Stcl/Stcl 		abnormal behavior J:262367
increased freezing behavior J:262367
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12/10/2024
MGI 6.24 		The Jackson Laboratory