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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bcl2
B cell leukemia/lymphoma 2
MGI:88138
135 phenotypes from 8 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bcl2drn/Bcl2drn
either: C57BL/6-Bcl2drn or (involves: C57BL/6JApb * CBA) 		diluted coat color J:104190
irregular coat pigmentation J:104190
Bcl2tm1Dlo/Bcl2tm1Dlo
B6.129P2-Bcl2tm1Dlo 		abnormal kidney development J:73316
abnormal kidney mesenchyme morphology J:153846
abnormal leukopoiesis J:73316
abnormal lymphocyte physiology J:73316, J:104487
abnormal nephrogenic zone morphology J:73316
decreased body size J:73316, J:104487, J:153846
decreased body weight J:153846
decreased nephron number J:73316
decreased spleen weight J:153846
decreased spleen white pulp amount J:153846
increased B cell apoptosis J:73316
increased splenocyte apoptosis J:153846
increased T cell apoptosis J:73316
kidney cyst J:73316, J:104487
polycystic kidney J:73316, J:153846
premature death J:73316, J:104487, J:153846
short ears J:73316
small metanephros J:73316
spleen atrophy J:153846
Bcl2tm1Dlo/Bcl2tm1Dlo
involves: 129P2/OlaHsd * C57BL/6 		abnormal coat/hair pigmentation J:73660
abnormal glomerular capillary endothelium morphology J:111022
abnormal glomerular capsule parietal layer morphology J:111022
abnormal kidney cortex morphology J:73660, J:111022
abnormal kidney corticomedullary boundary morphology J:33776
abnormal kidney development J:33776
abnormal kidney medulla morphology J:73660
abnormal kidney morphology J:73660
abnormal kidney vasculature morphology J:111022
abnormal nephrogenic zone morphology J:33776
abnormal podocyte morphology J:111022
abnormal renal glomerulus morphology J:33776
abnormal renal tubule epithelium morphology J:73660
abnormal T cell differentiation J:73660
abnormal ureteric bud elongation J:33776
decreased body size J:73660
decreased body weight J:73660
decreased CD8-positive, alpha-beta T cell number J:73660
decreased glomerular capsule space J:111022
decreased kidney weight J:111022
decreased lymphocyte cell number J:73660
decreased mature B cell number J:73660
decreased nephron number J:33776, J:111022
decreased pre-B cell number J:73660
decreased renal glomerulus number J:33776, J:73660, J:111022
decreased thymocyte number J:73660
dilated renal tubule J:33776, J:73660, J:111022
expanded mesangial matrix J:111022
glomerulosclerosis J:111022
impaired branching involved in ureteric bud morphogenesis J:33776
increased kidney apoptosis J:33776, J:111022
increased renal glomerulus apoptosis J:111022
kidney degeneration J:111022
kidney failure J:111022
mesangiolysis J:111022
pale kidney J:73660
podocyte foot process effacement J:111022
podocyte hypertrophy J:111022
polycystic kidney J:73660
postnatal lethality, incomplete penetrance J:73660
renal glomerular synechia J:111022
renal glomerulus hypertrophy J:33776, J:111022
renal hypoplasia J:33776
renal tubule hypertrophy J:33776, J:111022
round snout J:73660
small ears J:73660
small kidney J:33776, J:73660, J:111022
small ureteric bud J:33776
Bcl2tm1Irt/Bcl2tm1Irt
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		increased macrophage apoptosis J:144243
Bcl2tm1Lbox/Bcl2tm1Lbox
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal B cell activation J:114637
abnormal B cell differentiation J:114637
decreased B cell number J:114637
decreased B cell proliferation J:114637
decreased immature B cell number J:114637
decreased mature B cell number J:114637
decreased pre-B cell number J:114637
increased B cell apoptosis J:114637
Bcl2tm1Mpin/Bcl2tm1Mpin
involves: 129S2/SvPas * C57BL/6 		abnormal facial motor nucleus morphology J:34326
abnormal L3 dorsal root ganglion morphology J:34326
abnormal optic nerve morphology J:54876
abnormal superior cervical ganglion morphology J:34326
abnormal sympathetic neuron morphology J:34326
decreased body size J:34326
decreased sensory neuron number J:34326
increased blood urea nitrogen level J:34326
increased circulating creatinine level J:34326
motor neuron degeneration J:34326
polycystic kidney J:34326
premature death J:34326
retina ganglion cell degeneration J:54876
Bcl2tm1Sjk/Bcl2tm1Sjk
B6;129S2-Bcl2tm1Sjk/J 		abnormal skeletal muscle fiber type ratio J:66494
Bcl2tm1Sjk/Bcl2tm1Sjk
involves: 129S2/SvPas * C57BL/6 		abnormal CD4-positive, alpha beta T cell morphology J:15224
abnormal CD8-positive, alpha beta T cell morphology J:15224
abnormal cell adhesion J:53123
abnormal immune system organ morphology J:15224
abnormal induced retina neovascularization J:96232
abnormal kidney interstitium morphology J:15224
abnormal metanephric mesenchyme morphology J:22552
abnormal metanephric ureteric bud development J:22552
abnormal nephrogenic zone morphology J:22552
abnormal pericyte morphology J:96232
abnormal primordial ovarian follicle morphology J:28173
abnormal renal glomerulus morphology J:15224
abnormal renal tubule epithelium morphology J:15224
abnormal retina vasculature morphology J:96232
abnormal spleen morphology J:15224
abnormal spleen red pulp morphology J:15224
abnormal spleen white pulp morphology J:15224
abnormal thymus involution J:15224
abnormal thymus morphology J:15224
absent oocytes J:28173
cachexia J:15224
decreased B cell number J:15224
decreased body size J:15224
decreased double-positive T cell number J:15224
decreased kidney weight J:34504
decreased lymphocyte cell number J:15224
decreased nephron number J:22552
decreased renal glomerulus number J:22552
decreased T cell number J:15224
decreased vascular endothelial cell number J:96232
delayed kidney development J:34504
dilated distal convoluted tubule J:15224
dilated proximal convoluted tubule J:15224
enlarged kidney J:15224
hypopigmentation J:15224
increased blood urea nitrogen level J:15224, J:22552
increased circulating creatinine level J:15224, J:22552
increased compensatory renal growth J:34504
increased double-negative T cell number J:15224
increased kidney apoptosis J:34504
increased kidney cell proliferation J:15224, J:34504
increased metanephric mesenchyme apoptosis J:22552
increased T cell apoptosis J:15224
kidney cortex cyst J:22552, J:34504
kidney cyst J:15224, J:34504, J:53123
kidney failure J:22552
kidney medulla cyst J:34504
pale kidney J:15224
parietal capsular epithelium metaplasia J:15224
polycystic kidney J:15224, J:34504
postnatal growth retardation J:15224
postnatal lethality, incomplete penetrance J:15224
premature death J:15224
renal hypoplasia J:22552, J:34504
round snout J:15224
short snout J:15224
small ears J:15224
small kidney J:15224, J:22552
small metanephros J:22552
small spleen J:15224
small thymus J:15224
Bcl2tm1Sjk/Bcl2tm1Sjk
Tg(Dct-lacZ)A12Jkn/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA 		abnormal melanoblast morphology J:157070
Bcl2tm1Tsu/Bcl2tm1Tsu
involves: 129P2/OlaHsd * ICR 		abnormal kidney morphology J:22391
abnormal lymphocyte morphology J:22391
abnormal small intestinal villus morphology J:22391
abnormal small intestine crypts of Lieberkuhn morphology J:22391
abnormal small intestine morphology J:22391
abnormal T cell physiology J:22391
absent hair follicle melanin granules J:22391
decreased body size J:22391
decreased renal glomerulus number J:22391
decreased small intestinal villus height J:22391
dilated distal convoluted tubule J:22391
dilated proximal convoluted tubule J:22391
hypopigmentation J:22391
pale kidney J:22391
polycystic kidney J:22391
postnatal growth retardation J:22391
postnatal lethality, incomplete penetrance J:22391
premature death J:22391
small ears J:22391
small spleen J:22391
small thymus J:22391
spleen atrophy J:22391
thymus atrophy J:22391
Bcl2tm2.1Lbox/Bcl2+
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal B cell physiology J:175730
enlarged lymph nodes J:175730
enlarged spleen J:175730
increased B cell derived lymphoma incidence J:175730
increased B cell number J:175730
increased follicular lymphoma incidence J:175730
increased immature B cell number J:175730
increased mature B cell number J:175730
increased pre-B cell number J:175730
premature death J:175730
Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal B cell physiology J:175730
enlarged lymph nodes J:175730
enlarged spleen J:175730
increased B cell derived lymphoma incidence J:175730
increased B cell number J:175730
increased follicular lymphoma incidence J:175730
increased immature B cell number J:175730
increased mature B cell number J:175730
increased pre-B cell number J:175730
premature death J:175730
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory