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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bcl2
B cell leukemia/lymphoma 2
MGI:88138
47 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apoetm1Bres/Apoetm1Bres
Bcl2tm1Irt/Bcl2tm1Irt
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		atherosclerotic lesions J:144243
normal cardiovascular system phenotype J:144243
normal homeostasis/metabolism phenotype J:144243
increased macrophage apoptosis J:144243
Bcl2tm1.1Sjk/Bcl2tm1.1Sjk
Tg(APPV717F)109Ili/0
involves: 129X1/SvJ * C57BL/6 		premature death J:244104
Bcl2tm1.1Sjk/Bcl2tm1.1Sjk
Tg(CAG-EGFP/Map1lc3b)53Nmz/0
involves: 129X1/SvJ * C57BL/6 * C57BL/6NCrj * SJL 		abnormal basal metabolism J:181308
abnormal carbon dioxide production J:181308
abnormal cholesterol homeostasis J:181308
abnormal circulating adiponectin level J:181308
abnormal circulating glucose level J:181308
abnormal circulating insulin level J:181308
abnormal glucose homeostasis J:181308
abnormal glucose tolerance J:181308
abnormal oxygen consumption J:181308
abnormal percent body fat/body weight J:181308
abnormal triglyceride level J:181308
decreased muscle cell glucose uptake J:181308
impaired autophagy J:181308
impaired exercise endurance J:181308
increased circulating leptin level J:181308
normal muscle phenotype J:181308
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Ast/Bcl2l11+
B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast 		abnormal coat/hair pigmentation J:73316
abnormal hair follicle melanocyte morphology J:73316
abnormal lymphocyte physiology J:73316
absent hair follicle melanin granules J:73316
diluted coat color J:73316
normal hearing/vestibular/ear phenotype J:73316
increased T cell apoptosis J:73316
normal mortality/aging J:73316
normal renal/urinary system phenotype J:73316
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Ast/Bcl2l11+
B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast 		increased leukocyte cell number J:153846
increased spleen weight J:153846
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
B6.129-Bcl2tm1Dlo Bcl2l11tm1.1Ast 		abnormal leukopoiesis J:73316
abnormal lymphocyte physiology J:73316
decreased B cell apoptosis J:73316
normal hearing/vestibular/ear phenotype J:73316
increased T cell apoptosis J:73316
normal integument phenotype J:73316
normal mortality/aging J:73316
normal renal/urinary system phenotype J:73316
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast 		increased leukocyte cell number J:153846
increased spleen weight J:153846
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui 		diluted coat color J:153846
normal growth/size/body region phenotype J:153846
normal hematopoietic system phenotype J:153846
normal immune system phenotype J:153846
normal renal/urinary system phenotype J:153846
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui 		normal hematopoietic system phenotype J:153846
normal immune system phenotype J:153846
increased leukocyte cell number J:153846
increased spleen weight J:153846
normal renal/urinary system phenotype J:153846
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm2.1Boui/Bcl2l11tm2.1Boui
B6.Cg-Bcl2tm1Dlo Bcl2l11tm2.1Boui 		diluted coat color J:153846
normal growth/size/body region phenotype J:153846
normal hematopoietic system phenotype J:153846
normal immune system phenotype J:153846
normal renal/urinary system phenotype J:153846
Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui 		decreased splenocyte apoptosis J:153846
normal hematopoietic system phenotype J:153846
normal immune system phenotype J:153846
increased leukocyte cell number J:153846
increased spleen weight J:153846
polycystic kidney J:153846
postnatal growth retardation J:153846
premature death J:153846
Bcl2tm1Dlo/Bcl2tm1Dlo
Biktm1Ast/Biktm1Ast
B6.Cg-Bcl2tm1Dlo Biktm1Ast 		abnormal lymphocyte physiology J:104487
decreased body size J:104487
polycystic kidney J:104487
premature death J:104487
Bcl2tm1Mpin/Bcl2+
Tg(SFTPC-RAF1-BxB)1Urr/0
involves: 129S2/SvPas * C57BL/6 * DBA/2 		increased lung adenoma incidence J:79696
Bcl2tm1Mpin/Bcl2tm1Mpin
Tg(H2-K-BCL2)1Josd/0
Tg(SFTPC-RAF1-BxB)1Urr/0
involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2 		increased lung adenoma incidence J:79696
Bcl2tm1Mpin/Bcl2tm1Mpin
Tg(SFTPC-RAF1-BxB)1Urr/0
involves: 129S2/SvPas * C57BL/6 * DBA/2 		decreased tumor incidence J:79696
increased lung adenoma incidence J:79696
Destm1Cap/Destm1Cap
Tg(Bcl2)ACap/Tg(Bcl2)ACap
involves: 129S7/SvEvBrd * C57BL/6 		cardiac interstitial fibrosis J:88267
normal cardiovascular system phenotype J:88267
dystrophic cardiac calcinosis J:88267
Destm1Cap/Destm1Cap
Tg(Bcl2)BCap/Tg(Bcl2)BCap
involves: 129S7/SvEvBrd * C57BL/6 		abnormal myocardial fiber morphology J:88267
cardiac interstitial fibrosis J:88267
normal cardiovascular system phenotype J:88267
dystrophic cardiac calcinosis J:88267
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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07/05/2024
MGI 6.24 		The Jackson Laboratory