Bcl2l1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bcl2l1
BCL2-like 1
MGI:88139

36 phenotypes from 9 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bcl2l1^Plt16/Bcl2l1⁺ involves: BALB/c * C57BL/6	abnormal platelet physiology	J:149205
	increased megakaryocyte cell number	J:149205
	thrombocytopenia	J:149205
Bcl2l1^Plt16/Bcl2l1^Plt16 involves: BALB/c * C57BL/6	prenatal lethality, incomplete penetrance	J:149205
Bcl2l1^Plt20/Bcl2l1⁺ involves: BALB/c * C57BL/6	abnormal platelet physiology	J:149205
	increased megakaryocyte cell number	J:149205
	thrombocytopenia	J:149205
Bcl2l1^Plt20/Bcl2l1^Plt16 involves: BALB/c * C57BL/6	thrombocytopenia	J:149205
Bcl2l1^Plt20/Bcl2l1^Plt20 involves: BALB/c * C57BL/6	abnormal platelet physiology	J:149205
	extramedullary hematopoiesis	J:149205
	increased megakaryocyte cell number	J:149205
	thrombocytopenia	J:149205
Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam 7630403G23Rik^{Tg(Th-cre)1Tmd}/? involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal locus ceruleus morphology	J:99848
	abnormal motor capabilities/coordination/movement	J:99848
	decreased body weight	J:99848
	decreased brain weight	J:99848
	decreased dopamine level	J:99848
	decreased substantia nigra size	J:99848
Bcl2l1^tm1Cant/Bcl2l1^tm1Cant involves: 129S6/SvEvTac	abnormal memory T cell physiology	J:77507
	abnormal T cell physiology	J:77507
	decreased interleukin-2 secretion	J:77507
	decreased memory T cell number	J:77507
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:77507
	decreased T cell proliferation	J:77507
Bcl2l1^tm1Dlo/Bcl2l1⁺ B6.Cg-Bcl2l1^tm1Dlo	abnormal platelet physiology	J:149205
Bcl2l1^tm1Dlo/Bcl2l1⁺ B6.Cg-Bcl2l1^tm1Dlo	thrombocytopenia	J:149205
Bcl2l1^tm1Dlo/Bcl2l1^Plt20 involves: BALB/c * C57BL/6	thrombocytopenia	J:149205
Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu/0 B6.Cg-Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu	decreased IgG1 level	J:166069
	normal immune system phenotype	J:166069
Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Not Specified	increased apoptosis	J:39573
Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Not Specified	increased neuron apoptosis	J:39573
Bcl2l1^tm1Mam/Bcl2l1^tm1Mam involves: 129S6/SvEvTac * C57BL/6	abnormal apoptosis	J:63161
	decreased litter size	J:63161
	decreased primordial germ cell number	J:63161
	decreased primordial ovarian follicle number	J:63161
	male infertility	J:63161
	reduced female fertility	J:63161
	small testis	J:63161
Bcl2l1^tm1Tak/Bcl2l1^tm1Tak Tg(KRT5-cre)1Tak/0 involves: C3H * C57BL/6	decreased keratinocyte adhesion	J:82661
	increased cellular sensitivity to ultraviolet irradiation	J:82661
	increased keratinocyte apoptosis	J:82661
Bcl2l1^tm1Ywh/Bcl2l1^tm1Ywh Tg(Lck-cre)548Jxm/? involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA	decreased double-positive T cell number	J:99012
	decreased thymocyte number	J:99012
Tg(Lck-Bcl2l1)1Cant/? B6.Cg-Tg(Lck-Bcl2l1)1Cant	increased interleukin-2 secretion	J:77507
	increased memory T cell number	J:77507
	increased T cell proliferation	J:77507

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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