Bcl3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bcl3
B cell leukemia/lymphoma 3
MGI:88140

74 phenotypes from 9 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bcl3^m1Btlr/Bcl3⁺ C57BL/6J-Bcl3^m1Btlr	decreased B cell number	J:255184
	decreased B-1b cell number	J:255184
	increased CD8-positive, alpha-beta T cell number	J:255184
	increased macrophage cell number	J:255184
Bcl3^m1Btlr/Bcl3^m1Btlr C57BL/6J-Bcl3^m1Btlr	abnormal humoral immune response	J:255184
	decreased B cell number	J:255184
	decreased B-1b cell number	J:255184
	decreased IgE level	J:255184
	decreased IgG level	J:255184
	increased B-1 B cell number	J:255184
	increased CD8-positive, alpha-beta T cell number	J:255184
	increased central memory CD4-positive, alpha-beta T cell number	J:255184
	increased macrophage cell number	J:255184
Bcl3^m2Btlr/Bcl3^m2Btlr C57BL/6J-Bcl3^m2Btlr	decreased CD4-positive, alpha-beta T cell number	J:264818
	decreased IgD level	J:264818
	increased B-1 B cell number	J:264818
	increased CD8-positive, alpha-beta memory T cell number	J:264818
	increased IgM level	J:264818
Bcl3^m3Btlr/Bcl3^m3Btlr C57BL/6J-Bcl3^m3Btlr	decreased central memory CD8 positive, alpha-beta T cell number	J:274858
Bcl3^{tm1b(EUCOMM)Wtsi}/Bcl3^{tm1b(EUCOMM)Wtsi} C57BL/6N-Bcl3^{tm1b(EUCOMM)Wtsi}/H	abnormal snout morphology	J:211773
	increased spleen weight	J:211773
	thrombocytopenia	J:211773
Bcl3^tm1Rie/Bcl3^tm1Rie involves: 129	abnormal dendritic cell number	J:77049
	abnormal follicular dendritic cell morphology	J:77049
	abnormal myeloid dendritic cell morphology	J:77049
	abnormal Peyer's patch follicle morphology	J:77049
	abnormal Peyer's patch germinal center morphology	J:77049
	abnormal Peyer's patch morphology	J:77049
	abnormal Peyer's patch T cell area morphology	J:77049
	decreased B cell number	J:77049
	decreased Peyer's patch number	J:77049
	increased plasmacytoid dendritic cell number	J:77049
	small Peyer's patches	J:77049
Bcl3^tm1Rsch/Bcl3^tm1Rsch B6.Cg-Bcl3^tm1Rsch	abnormal cytokine secretion	J:116724
	abnormal enzyme/coenzyme activity	J:116724
	abnormal macrophage physiology	J:116724
Bcl3^tm1Rsch/Bcl3^tm1Rsch involves: 129P2/OlaHsd * CD-1	abnormal cytokine secretion	J:116724
	abnormal innate immunity	J:116724
	increased susceptibility to bacterial infection	J:116724
Bcl3^tm1Sbn/Bcl3^tm1Sbn involves: 129S4/SvJae	abnormal B cell physiology	J:207111
	decreased B cell proliferation	J:207111
	decreased follicular B cell number	J:207111
	decreased transitional stage T1 B cell number	J:207111
	decreased transitional stage T2 B cell number	J:207111
	increased B cell proliferation	J:207111
	increased marginal zone B cell number	J:207111
Bcl3^tm1Sbn/Bcl3^tm1Sbn involves: 129S4/SvJae * C57BL/6	abnormal B cell differentiation	J:39747
	abnormal class switch recombination	J:39747
	abnormal cytotoxic T cell physiology	J:39747
	abnormal lymph node B cell domain morphology	J:39747
	abnormal lymphocyte morphology	J:39747
	abnormal metallophilic macrophage morphology	J:39747
	abnormal nitric oxide homeostasis	J:39747
	abnormal spleen marginal zone macrophage morphology	J:39747
	absent spleen germinal center	J:39747
	decreased B cell number	J:39747
	decreased IgG2a level	J:39747
	decreased interferon-gamma secretion	J:39747
	decreased interleukin-12 secretion	J:39747
	decreased macrophage cell number	J:39747
	decreased spleen germinal center size	J:39747
	disorganized spleen B cell follicle	J:39747
	increased susceptibility to induced morbidity/mortality	J:39747
	increased susceptibility to parasitic infection	J:39747
	intermingled spleen red and white pulp	J:39747
	lymph node hypoplasia	J:39747
Bcl3^tm1Ver/Bcl3^tm1Ver involves: 129P2/OlaHsd * FVB/NJ	abnormal humoral immune response	J:38092
	absent spleen germinal center	J:38092
	normal immune system phenotype	J:38092
	increased susceptibility to bacterial infection	J:38092
Gt(ROSA)26Sor^{tm1(CAG-Bcl3,-EGFP)Hoev}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd	abnormal B cell differentiation	J:208980
	abnormal B-2 B cell morphology	J:208980
	abnormal class switch recombination	J:208980
	abnormal follicular B cell morphology	J:208980
	abnormal Peyer's patch germinal center morphology	J:208980
	abnormal transitional stage T3 B cell morphology	J:208980
	absent marginal zone B cells	J:208980
	decreased B cell apoptosis	J:208980
	decreased B cell proliferation	J:208980
	decreased B-1 B cell number	J:208980
	decreased B-1a cell number	J:208980
	decreased IgG1 level	J:208980
	decreased IgG2b level	J:208980
	decreased IgG3 level	J:208980
	decreased IgM level	J:208980
	decreased immature B cell number	J:208980
	decreased marginal zone B cell number	J:208980
	decreased transitional stage T1 B cell number	J:208980
	enlarged spleen	J:208980
	increased lymphocyte cell number	J:208980

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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