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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bcr
BCR activator of RhoGEF and GTPase
MGI:88141
20 phenotypes from 2 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bcrtm1(BCR/ABL)Tsr/Bcr+
C57BL/6-Bcrtm1(BCR/ABL)Tsr 		abnormal bone marrow cell physiology J:203111
decreased hematopoietic stem cell number J:203111
Bcrtm1(BCR/ABL)Tsr/Bcr+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		no abnormal phenotype detected J:203111
Bcrtm1(BCR/ABL)Tsr/Bcr+
Tg(CMV-cre)1Cgn/0
involves: BALB/c * C57BL/6 		no abnormal phenotype detected J:203111
Bcrtm1(BCR/ABL)Tsr/Bcr+
Tg(Vav1-cre)#Cgp/0
involves: C57BL/6 		abnormal bone marrow cell physiology J:203111
Bcrtm1(BCR/ABL)Tsr/Bcrtm1(BCR/ABL)Tsr
Tg(Vav1-cre)#Cgp/0
involves: C57BL/6 		no abnormal phenotype detected J:203111
Bcrtm1Hkp/Bcrtm1Hkp
involves: 129S2/SvPas 		abnormal definitive hematopoiesis J:23804
abnormal ileum morphology J:23804
abnormal liver parenchyma morphology J:23804
abnormal neutrophil physiology J:23804
abnormal proximal convoluted tubule morphology J:23804
abnormal renal glomerulus morphology J:23804
increased blood urea nitrogen level J:23804
increased circulating alanine transaminase level J:23804
increased circulating aspartate transaminase level J:23804
increased circulating lactate dehydrogenase level J:23804
increased leukocyte cell number J:23804
increased neutrophil cell number J:23804
increased susceptibility to endotoxin shock J:23804
intestinal edema J:23804
renal necrosis J:23804
sepsis J:23804
weight loss J:23804
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory