About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bdnf
brain derived neurotrophic factor
MGI:88145
154 phenotypes from 21 alleles in 28 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
involves: 129P2/OlaHsd 		abnormal cochlea morphology J:82462
abnormal crista ampullaris morphology J:82462
abnormal fungiform papillae morphology J:82462
abnormal geniculate ganglion morphology J:82462
abnormal gustatory system morphology J:82462
abnormal inner ear vestibular sensory neuron innervation pattern J:82462
abnormal innervation J:82462
abnormal sensory neuron morphology J:82462
abnormal vestibular ganglion morphology J:82462
normal hearing/vestibular/ear phenotype J:82462
impaired balance J:82462
impaired coordination J:82462
increased body weight J:82462
premature death J:82462
small nodose ganglion J:82462
vestibular ganglion degeneration J:82462
Bdnftm1.1Krj/Bdnf+
involves: 129S2/SvPas * C57BL/6 		abnormal dendritic spine morphology J:184139
normal nervous system phenotype J:184139
Bdnftm1.1Krj/Bdnftm1.1Krj
involves: 129S2/SvPas 		abnormal mammary gland sensory innervation pattern J:192549
Bdnftm1.1Tes/Bdnftm1.1Tes
B6.129X1-Bdnftm1.1Tes 		no abnormal phenotype detected J:146179
Bdnftm1.1Tmiz/Bdnf+
B6.Cg-Bdnftm1.1Tmiz 		abnormal nest building behavior J:303078
behavioral despair J:303078
increased body weight J:303078
increased food intake J:303078
Bdnftm1.1Tmiz/Bdnftm1.1Tmiz
B6.Cg-Bdnftm1.1Tmiz 		normal cardiovascular system phenotype J:303078
normal growth/size/body region phenotype J:303078
Bdnftm1Bail/Bdnftm1Bail
B6.129-Bdnftm1Bail 		abnormal brain interneuron morphology J:147571
abnormal inhibitory postsynaptic currents J:147571
abnormal nervous system physiology J:147571
abnormal synaptic plasticity J:147571
Bdnftm1Gdy/Bdnf+
involves: 129P2/OlaHsd 		small vestibular ganglion J:110692
vestibular ganglion degeneration J:110692
Bdnftm1Gdy/Bdnftm1Gdy
involves: 129P2/OlaHsd 		abnormal cochlear OHC afferent innervation pattern J:110692
abnormal inner ear vestibular sensory neuron innervation pattern J:110692
abnormal motor coordination/balance J:25565
decreased brain size J:25565
decreased sensory neuron number J:25565
hyperactivity J:25565
impaired righting response J:25565
postnatal growth retardation J:25565
postnatal lethality, incomplete penetrance J:25565
small nodose ganglion J:25565
small petrosal ganglion J:25565
small trigeminal ganglion J:25565
small vestibular ganglion J:25565, J:110692
vestibular ganglion degeneration J:110692
Bdnftm1Jae/Bdnftm1Jae
B6.129S4-Bdnftm1Jae 		abnormal gustatory papilla taste bud morphology J:90280
abnormal sensory neuron innervation pattern J:90280
Bdnftm1Jae/Bdnftm1Jae
involves: 129S4/SvJae 		abnormal cochlear ganglion morphology J:82462
abnormal crista ampullaris morphology J:82462
abnormal fungiform papillae morphology J:82462
abnormal inner ear vestibular sensory neuron innervation pattern J:17123, J:82462
abnormal sensory neuron innervation pattern J:82462
abnormal trigeminal nerve morphology J:123022
abnormal type I vestibular cell J:17123
abnormal vestibular ganglion morphology J:82462
circling J:17123
deafness J:82462
decreased body size J:17123
decreased sensory neuron number J:17123, J:25566
head bobbing J:17123
head tilt J:17123
normal hearing/vestibular/ear phenotype J:17123
hyperactivity J:17123
impaired balance J:17123
impaired limb coordination J:17123
increased neuron apoptosis J:123022
normal nervous system phenotype J:17123
postnatal lethality, incomplete penetrance J:17123, J:82462
small geniculate ganglion J:25566, J:82462
small L4 dorsal root ganglion J:17123, J:82462
small mesencephalic trigeminal nucleus J:17123
small nodose ganglion J:17123, J:25566, J:82462
small petrosal ganglion J:25566
small trigeminal ganglion J:17123
small vestibular ganglion J:17123, J:25566
spinning J:17123
Bdnftm1Jae/Bdnftm1Jae
involves: 129S4/SvJae * BALB/c 		abnormal neuron apoptosis J:46125
abnormal neuron morphology J:46125
increased neuron number J:46125
Bdnftm1Jae/Bdnftm2(Ntf5)Jae
involves: 129S4/SvJae 		no abnormal phenotype detected J:61340
Bdnftm1Jben/Bdnf+
involves: C57BL/6 		abnormal neuron morphology J:111309
abnormal striatum morphology J:111309
decreased locomotor activity J:111309
weight loss J:111309
Bdnftm1Krj/Bdnf+
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas * C57BL/6J 		normal growth/size/body region phenotype J:84683
Bdnftm1Krj/Bdnftm1Krj
involves: 129S2/SvPas * C57BL/6 		abnormal dendrite morphology J:184139
abnormal GABAergic neuron morphology J:184139
abnormal nervous system electrophysiology J:184139
abnormal nervous system physiology J:184139
normal nervous system phenotype J:184139
Bdnftm1Krj/Bdnftm1Lfr
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas * C57BL/6J 		abnormal cerebral cortex morphology J:96903
abnormal hippocampus morphology J:96903
abnormal medium spiny neuron morphology J:96903
abnormal nest building behavior J:84683
abnormal visual cortex morphology J:84683
decreased body weight J:84683
decreased striatum size J:96903
delayed eyelid opening J:84683
increased aggression J:84683
limb grasping J:96903
obese J:84683
premature death J:84683
reduced fertility J:84683
thin cerebral cortex J:84683
Bdnftm1Krj/Bdnftm1Lfr
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S2/SvPas * C57BL/6 * CBA 		abnormal substantia nigra morphology J:99291
abnormal substantia nigra pars compacta morphology J:99291
impaired coordination J:99291
limb grasping J:99291
Bdnftm1Lfr/Bdnf+
involves: 129S2/SvPas * C57BL/6J 		obese J:84683
Bdnftm1Lfr/Bdnftm1Lfr
involves: 129S2/SvPas 		abnormal circumvallate papillae morphology J:55127
abnormal fungiform papillae morphology J:55127
abnormal gustatory papilla taste bud morphology J:55127
decreased body size J:55127
short tongue J:55127
shortened head J:55127
Bdnftm1Lfr/Bdnftm1Lfr
involves: 129S2/SvPas * C57BL/6 		abnormal cerebellum external granule cell layer morphology J:67231
abnormal cranial ganglia morphology J:67231
abnormal locomotor activation J:67231
abnormal motor capabilities/coordination/movement J:67231
abnormal neuron differentiation J:67231
abnormal sensory ganglion morphology J:67231
abnormal somatic sensory system morphology J:67231
abnormal vestibular ganglion morphology J:67231
ataxia J:67231
decreased pulmonary respiratory rate J:67231
decreased sensory neuron number J:67231
hunched posture J:67231
impaired righting response J:67231
postnatal lethality, complete penetrance J:67231
small dorsal root ganglion J:67231
small geniculate ganglion J:67231
small mesencephalic trigeminal nucleus J:67231
small nodose ganglion J:67231
small petrosal ganglion J:67231
spinning J:67231
Bdnftm1Limm/Bdnftm1Limm
Tg(Camk2a-cre)T50Stl/0
involves: BALB/c * C57BL/6 		abnormal depression-related behavior J:129526
abnormal liquid preference J:129526
increased locomotor activity J:129526
Bdnftm1Limm/Bdnftm1Limm
Tg(GFAP-cre)25Mes/0
involves: FVB/N 		abnormal depression-related behavior J:129526
increased locomotor activity J:129526
Bdnftm1Meg/Bdnftm1Meg
Not Specified 		abnormal axon pruning J:139381
Bdnftm1Msd/Bdnftm1Msd
Mapttm1(cre)Nagy/Mapt+
involves: 129S1/Sv * 129X1/SvJ 		normal mortality/aging J:131394
normal nervous system phenotype J:131394
reduced long-term potentiation J:131394
Bdnftm1Par/Bdnf+
B6.129S1-Bdnftm1Par 		abnormal CNS synaptic transmission J:59077
abnormal locomotor activation J:59077
abnormal serotonergic neuron morphology J:59077
abnormal serotonin level J:59077
decreased vertical activity J:59077
increased aggression towards male mice J:59077, J:144845
increased body weight J:144845
increased circulating insulin level J:59077
increased susceptibility to age related obesity J:59077
polyphagia J:59077
Bdnftm1Par/Bdnf+
involves: 129S1/Sv 		decreased exploration in new environment J:113019
decreased hippocampus volume J:113019
increased aggression towards male mice J:113019
increased anxiety-related response J:113019
increased body weight J:113019
Bdnftm1Par/Bdnftm1Par
involves: 129S1/Sv 		abnormal barrel cortex morphology J:103935
abnormal dorsal root ganglion morphology J:60927
abnormal sensory neuron innervation pattern J:103935
abnormal somatic nervous system morphology J:44286
decreased sensory neuron number J:44286, J:60927
increased neuron apoptosis J:60927
postnatal lethality, complete penetrance J:44286
small dorsal root ganglion J:60927
small geniculate ganglion J:44286
small L4 dorsal root ganglion J:44286
small nodose ganglion J:44286
small petrosal ganglion J:44286
small trigeminal ganglion J:44286, J:60927
Bdnftm1Sieg/Bdnftm1Sieg
involves: 129S/SvEv * C57 		no abnormal phenotype detected J:85602
Bdnftm1Sieg/Bdnftm1Sieg
Tg(Camk2a-cre)1Szi/0
involves: 129S/SvEv * C57BL/6 * CBA 		reduced long-term potentiation J:85602
Bdnftm1Sieg/Bdnftm1Sieg
Tg(Camk2a-cre)3Szi/0
involves: 129S/SvEv * C57BL/6 * CBA 		no abnormal phenotype detected J:85602
Bdnftm1Tbn/Bdnf+
involves: 129S4/SvJae * NMRI 		abnormal excitatory postsynaptic potential J:64962
impaired synaptic plasticity J:64962
reduced long-term potentiation J:64962
Bdnftm1Tbn/Bdnftm1Tbn
involves: 129S2/SvPas 		abnormal adrenergic neuron morphology J:56217
abnormal innervation J:56217
abnormal keratinocyte morphology J:54992
abnormal sympathetic system morphology J:56217
Bdnftm1Tbn/Bdnftm1Tbn
involves: 129S4/SvJae * NMRI 		abnormal cochlear OHC afferent innervation pattern J:84871
abnormal colon goblet cell morphology J:110612
abnormal colon morphology J:110612
abnormal excitatory postsynaptic potential J:64962
abnormal hair cycle J:53271
abnormal intestine morphology J:110612
decreased body weight J:64962
decreased sensory neuron number J:64962
impaired balance J:64962
impaired limb coordination J:64962
impaired synaptic plasticity J:64962
postnatal growth retardation J:64962
postnatal lethality, complete penetrance J:64962
reduced long-term potentiation J:64962
small dorsal root ganglion J:64962
Bdnftm1Yab/Bdnftm1Yab
Mapttm1(cre)Nagy/Mapt+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal dendrite morphology J:157932
abnormal locomotor activation J:157932
abnormal neuron morphology J:157932
abnormal optic nerve morphology J:157932
decreased body weight J:157932
decreased brain size J:157932
decreased brain weight J:157932
decreased striatum size J:157932
increased anxiety-related response J:157932
increased body weight J:157932
limb grasping J:157932
postnatal growth retardation J:157932
postnatal lethality, complete penetrance J:157932
Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
involves: 129S4/SvJae 		decreased body weight J:61340
excessive scratching J:61340
female infertility J:61340
normal nervous system phenotype J:61340
reduced male fertility J:61340
Bdnftm3Jae/Bdnftm3Jae
involves: 129S4/SvJae 		no abnormal phenotype detected J:71969
Bdnftm3Jae/Bdnftm3Jae
involves: 129S4/SvJae 		normal behavior/neurological phenotype J:157538
impaired cued conditioning behavior J:157538
Bdnftm3Jae/Bdnftm3Jae
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * CBA/J 		abnormal hippocampus CA2 region morphology J:106973
abnormal homeostasis J:71969
abnormal olfactory bulb morphology J:106973
decreased brain weight J:106973
hyperactivity J:71969
increased aggression towards male mice J:71969
increased anxiety-related response J:71969
increased body length J:71969
increased cholesterol level J:71969
increased circulating glucose level J:71969
increased circulating insulin level J:71969
increased circulating leptin level J:71969
insulin resistance J:71969
limb grasping J:106973
obese J:71969
polyphagia J:71969
reduced female fertility J:71969
Bdnftm3Jae/Bdnftm3Jae
Tg(Camk2a-cre)159Kln/0
involves: 129S4/SvJae * CBA/J 		hyperactivity J:71969
obese J:71969
Bdnftm3Jae/Bdnftm3Jae
Tg(Cck-cre)CKres/0
involves: 129S4/SvJae * C57BL/6 		normal behavior/neurological phenotype J:157538
impaired cued conditioning behavior J:157538
Bdnftm3Jae/Bdnftm3Jae
Tg(Eno2tTA)5030Nes/0
Tg(tetO-cre)1Jaw/0
involves: 129/Sv * C57BL/6 * ICR * SJL 		abnormal contextual conditioning behavior J:91563
abnormal cued conditioning behavior J:91563
hyperactivity J:91563
impaired behavioral response to xenobiotic J:91563
reduced long-term potentiation J:91563
Bdnftm3Jae/Bdnftm3Jae
Tg(Syn1-cre)671Jxm/0
involves: 129/Sv * C57BL/6 * ICR 		abnormal kindling response J:91467
Tg(Bdnf)1Kma/0
involves: C3H * C57BL/6J 		abnormal cutaneous/subcutaneous mechanoreceptor morphology J:65163
enlarged Meissner's corpuscles J:65163
hyperinnervation of hair guard cells J:65163
hyperinnervation of hair-down cells J:65163
hyperinnervation of hair-tylotrich cells J:65163
hyperinnervation of Meissner's corpuscle J:65163
hyperinnervation of Merkel's receptor J:65163
increased Merkel's receptor number J:65163
Tg(Bdnf)1Paus/0
involves: FVB 		abnormal adrenergic neuron morphology J:56217
abnormal hair cycle J:53271
abnormal innervation J:56217
abnormal keratinocyte morphology J:54992
abnormal sensory neuron innervation pattern J:110609
abnormal sympathetic system morphology J:56217
increased Merkel's receptor number J:110609
short hair J:53271
thick epidermis J:54992
thin skin J:53271
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory