Bdnf Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bdnf
brain derived neurotrophic factor
MGI:88145

37 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Bdnf^{tm1(BDNF)Gogo}/Bdnf⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/? involves: 129S/SvEv	normal nervous system phenotype	J:124050
Bdnf^tm1Flee/Bdnf⁺ B6.129-Bdnf^tm1Flee	abnormal contextual conditioning behavior	J:113019
	abnormal dendrite morphology	J:113019
	abnormal dentate gyrus morphology	J:113019
	abnormal neuron physiology	J:113019
	decreased hippocampus volume	J:113019
Bdnf^tm1Flee/Bdnf^tm1Flee B6.129-Bdnf^tm1Flee	abnormal contextual conditioning behavior	J:113019
	abnormal dendrite morphology	J:113019
	abnormal dentate gyrus morphology	J:113019
	abnormal neuron physiology	J:113019
	decreased exploration in new environment	J:113019
	decreased hippocampus volume	J:113019
	increased aggression towards male mice	J:113019
	increased anxiety-related response	J:113019
	increased body weight	J:113019
Bdnf^tm1Gdy/Bdnf^tm1Gdy Ntf5^tm1Gdy/Ntf5^tm1Gdy involves: 129P2/OlaHsd	abnormal motor coordination/balance	J:25565
	decreased sensory neuron number	J:25565
	hyperactivity	J:25565
	impaired righting response	J:25565
	postnatal growth retardation	J:25565
	postnatal lethality, complete penetrance	J:25565
	small nodose ganglion	J:25565
	small petrosal ganglion	J:25565
	small trigeminal ganglion	J:25565
	small vestibular ganglion	J:110692
Bdnf^tm1Jae/Bdnf⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/? involves: 129S4/SvJae * C57BL/6	normal nervous system phenotype	J:124050
Bdnf^tm1Jae/Bdnf^tm1Jae Ntf5^tm1Jae/Ntf5^tm1Jae involves: 129S4/SvJae	abnormal trigeminal nerve morphology	J:123022
	decreased sensory neuron number	J:25566
	impaired balance	J:25566
	impaired coordination	J:25566
	postnatal growth retardation	J:25566
	postnatal lethality, complete penetrance	J:25566
	small geniculate ganglion	J:25566
	small nodose ganglion	J:25566
	small petrosal ganglion	J:25566
	small trigeminal ganglion	J:25566
	small vestibular ganglion	J:25566
Bdnf^tm1Jae/Bdnf^tm2(Ntf5)Jae Ntrk2^tm1Kln/Ntrk2^tm1Kln involves: 129S4/SvJae	decreased sensory neuron number	J:61340
	head bobbing	J:61340
	hyperactivity	J:61340
	spinning	J:61340
Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2⁺ B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes	increased aggression towards male mice	J:144845
Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes	increased aggression towards male mice	J:144845
	increased body weight	J:144845
Bdnf^tm1Par/Bdnf^tm1Par Ntf3^tm1Par/Ntf3^tm1Par involves: 129S1/Sv	abnormal somatic nervous system morphology	J:44286
	abnormal vestibular ganglion morphology	J:44286
	abnormal vestibulocochlear ganglion morphology	J:44286
	decreased sensory neuron number	J:44286
	neonatal lethality, complete penetrance	J:44286
	small geniculate ganglion	J:44286
	small L4 dorsal root ganglion	J:44286
	small nodose ganglion	J:44286
	small petrosal ganglion	J:44286
	small trigeminal ganglion	J:44286
Bdnf^tm1Par/Bdnf^tm1Par Ntf5^tm1Par/Ntf5^tm1Par involves: 129S1/Sv * C57BL/6	abnormal dorsal root ganglion morphology	J:60927
	abnormal neuron differentiation	J:60927
Bdnf^{tm2(BDNF)Gogo}/Bdnf⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/? involves: 129S/SvEv	abnormal olfactory nerve morphology	J:124050
Bdnf^tm2(Ntf5)Jae/Bdnf^tm2(Ntf5)Jae Ntrk2^tm1Kln/Ntrk2^tm1Kln involves: 129S4/SvJae	hyperactivity	J:61340
Bdnf^tm3Jae/Bdnf⁺ Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0 involves: 129S4/SvJae * C57BL/6 * CBA/J	premature death	J:106973
Bdnf^tm3Jae/Bdnf^tm3Jae Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0 involves: 129S4/SvJae * C57BL/6 * CBA/J	abnormal action potential	J:106973
	lethargy	J:106973
	premature death	J:106973

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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