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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bglap
bone gamma carboxyglutamate protein
MGI:88156
38 phenotypes from 2 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bglap/Bglap2tm1Kry/Bglap/Bglap2tm1Kry
involves: 129S7/SvEvBrd 		abnormal fat cell morphology J:126780
abnormal glucose homeostasis J:126780
abnormal pancreatic islet morphology J:126780
abnormal seminiferous tubule epithelium morphology J:170888
abnormal spermatid morphology J:170888
abnormal spermatocyte morphology J:170888
decreased adipocyte glucose uptake J:126780
decreased circulating insulin level J:126780
decreased circulating testosterone level J:170888
decreased energy expenditure J:126780
decreased epididymis weight J:170888
decreased insulin secretion J:126780
decreased Leydig cell number J:170888
decreased pancreatic beta cell mass J:126780
decreased pancreatic beta cell proliferation J:126780
decreased pancreatic islet number J:126780
decreased seminal vesicle weight J:170888
decreased testis weight J:170888
impaired glucose tolerance J:126780
increased circulating estradiol level J:170888
increased circulating glucose level J:126780
increased circulating luteinizing hormone level J:170888
increased circulating triglyceride level J:126780
increased total body fat amount J:126780
insulin resistance J:126780
oligozoospermia J:170888
normal reproductive system phenotype J:170888
small pancreatic islets J:126780
small testis J:170888
Bglap/Bglap2tm1Kry/Bglap/Bglap2tm1Kry
involves: 129S7/SvEvBrd * C57BL/6 		abnormal bone remodeling J:34440
abnormal bone structure J:34440
abnormal long bone diaphysis morphology J:34440
abnormal skeleton development J:34440
increased bone mass J:34440
increased bone strength J:34440
increased compact bone thickness J:34440
increased osteoclast cell number J:34440
increased trabecular bone thickness J:34440
Bglap/Bglap2tm3.1Kry/Bglap/Bglap2tm3.1Kry
Tg(Col1a1-cre)1Kry/0
involves: FVB 		decreased circulating testosterone level J:170888
decreased epididymis weight J:170888
decreased seminal vesicle weight J:170888
decreased testis weight J:170888
oligozoospermia J:170888
small testis J:170888
Bglap/Bglap2tm3.1Kry/Bglap/Bglap2tm3.1Kry
Tg(Cyp17a1-icre)AJako/0
involves: C57BL/6 * SJL 		normal reproductive system phenotype J:170888
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory