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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bmi1
Bmi1 polycomb ring finger oncogene
MGI:88174
119 phenotypes from 6 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bmi1tm1.1(KOMP)Vlcg/Bmi1+
C57BL/6N-Bmi1tm1.1(KOMP)Vlcg/MbpMmucd 		abnormal embryo size J:211773
anophthalmia J:211773
edema J:211773
Bmi1tm1.1(KOMP)Vlcg/Bmi1tm1.1(KOMP)Vlcg
C57BL/6N-Bmi1tm1.1(KOMP)Vlcg/MbpMmucd 		abnormal embryo size J:211773
edema J:211773
microphthalmia J:211773
Bmi1tm1.1(KOMP)Vlcg/Bmi1tm1.1(KOMP)Vlcg
C57BL/6N-Bmi1tm1.1(KOMP)Vlcg/Ucd 		preweaning lethality, complete penetrance J:211773
preweaning lethality, incomplete penetrance J:211773
Bmi1tm1.1Lees/Bmi1tm1.1Lees
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:204354
Bmi1tm1Brn/Bmi1+
involves: 129P2/OlaHsd 		cervical vertebral transformation J:134271
lumbar vertebral transformation J:134271
thoracic vertebral transformation J:134271
Bmi1tm1Brn/Bmi1tm1Brn
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * FVB) 		abnormal bone marrow cell morphology/development J:17712
abnormal cerebellar layer morphology J:17712
abnormal corpus callosum morphology J:17712
abnormal definitive hematopoiesis J:17712
abnormal double-negative T cell morphology J:17712
abnormal Purkinje cell morphology J:17712
abnormal spleen red pulp morphology J:17712
abnormal spleen white pulp morphology J:17712
abnormal thymus involution J:17712
abnormal vertebral arch morphology J:17712
anemia J:17712
ataxia J:17712
cervical vertebral transformation J:17712
decreased body size J:17712
decreased IgM level J:17712
decreased immature B cell number J:17712
decreased mature B cell number J:17712
decreased Purkinje cell number J:17712
decreased splenocyte proliferation J:17712
decreased thymocyte number J:17712
gliosis J:17712
hippocampal neuron degeneration J:17712
lumbar vertebral transformation J:17712
lung inflammation J:17712
postnatal lethality, incomplete penetrance J:17712
premature death J:17712
small spleen J:17712
sporadic seizures J:17712
thin cerebellar molecular layer J:17712
thoracic vertebral transformation J:17712
thymus cortex hypoplasia J:17712
tremors J:17712
vertebral transformation J:17712
Bmi1tm1Brn/Bmi1tm1Brn
involves: 129P2/OlaHsd 		abnormal bone marrow cell morphology/development J:134271
abnormal cell cycle J:134271
abnormal enzyme/coenzyme level J:286451
abnormal epididymis morphology J:286451
abnormal male germ cell physiology J:286451
abnormal seminiferous tubule epithelium morphology J:286451
abnormal sperm head morphology J:286451
abnormal sperm mitochondrial sheath morphology J:286451
abnormal sperm nucleus morphology J:286451
abnormal testis physiology J:286451
abnormal vertebrae morphology J:134271
anemia J:134271
ataxia J:134271
cerebellum hypoplasia J:134271
cervical vertebral transformation J:134271
decreased bone marrow cell number J:134271
decreased cell proliferation J:134271
decreased circulating testosterone level J:286451
decreased double-positive T cell number J:134271
decreased hematopoietic cell number J:134271
decreased Leydig cell number J:286451
decreased male germ cell number J:286451
decreased testes secretion J:286451
decreased testis weight J:286451
detached acrosome J:286451
early cellular replicative senescence J:134271, J:198334
enlarged sperm head J:286451
increased male germ cell apoptosis J:286451
lumbar vertebral transformation J:134271
male infertility J:286451
oligozoospermia J:286451
oxidative stress J:286451
postnatal growth retardation J:134271
postnatal lethality, incomplete penetrance J:134271
premature death J:134271
small seminiferous tubules J:286451
small testis J:286451
teratozoospermia J:286451
thoracic vertebral transformation J:134271
Bmi1tm1Brn/Bmi1tm1Brn
involves: 129P2/OlaHsd * C57BL/6J * FVB/N 		abnormal enzyme/coenzyme level J:287217
abnormal estrous cycle J:287217
abnormal mitochondrial crista morphology J:287217
abnormal mitochondrial morphology J:287217
abnormal ovary development J:287217
abnormal ovary physiology J:287217
decreased granulosa cell proliferation J:287217
decreased mature ovarian follicle number J:287217
decreased mitochondrial number J:287217
decreased oocyte number J:287217
decreased ovary weight J:287217
decreased primary ovarian follicle number J:287217
decreased primordial ovarian follicle number J:287217
decreased secondary ovarian follicle number J:287217
decreased superovulation rate J:287217
decreased superoxide dismutase level J:287217
delayed vaginal opening J:287217
failure of zygotic cell division J:287217
female infertility J:287217
increased atretic ovarian follicle number J:287217
increased granulosa cell apoptosis J:287217
oxidative stress J:287217
prolonged diestrus J:287217
prolonged metestrus J:287217
short estrus J:287217
short proestrus J:287217
small ovary J:287217
Bmi1tm1Ilw/Bmi1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:138039
Bmi1tm1Sgon/Bmi1tm1Sgon
Commd10Tg(Vav1-icre)A2Kio/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca 		abnormal erythropoiesis J:221849
abnormal hemopoiesis J:221849
abnormal immune system cell morphology J:221849
abnormal immune system organ morphology J:221849
abnormal spleen morphology J:221849
abnormal spleen periarteriolar lymphoid sheath morphology J:221849
abnormal spleen white pulp morphology J:221849
abnormal thymus morphology J:221849
absent spleen germinal center J:221849
decreased B cell number J:221849
decreased bone marrow cell number J:221849
decreased common myeloid progenitor cell number J:221849
decreased hematopoietic stem cell number J:221849
decreased myeloid cell number J:221849
decreased spleen red pulp amount J:221849
decreased spleen white pulp amount J:221849
decreased T cell number J:221849
increased common lymphocyte progenitor cell number J:221849
premature death J:221849
small spleen J:221849
small thymus J:221849
thymus atrophy J:221849
Bmi1tm1Sgon/Bmi1tm1Sgon
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		decreased hematopoietic stem cell number J:221849
decreased lymphocyte cell number J:221849
decreased spleen weight J:221849
normal hematopoietic system phenotype J:221849
normal immune system phenotype J:221849
normal mortality/aging J:221849
premature death J:221849
Bmi1tm2Ilw/Bmi1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:138039
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory