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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bmp2
bone morphogenetic protein 2
MGI:88177
79 phenotypes from 9 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bmp2tm1(KOMP)Vlcg/Bmp2+
involves: C57BL/6NTac 		decreased body length J:258535
decreased bone mineral content J:258535
decreased bone volume J:258535
decreased rib number J:258535
Bmp2tm1(KOMP)Vlcg/Bmp2tm1(KOMP)Vlcg
involves: C57BL/6NTac 		embryonic lethality prior to tooth bud stage J:258535
Bmp2tm1.1Jfm/Bmp2tm1.1Jfm
Not Specified 		abnormal heart development J:99582
abnormal neural tube morphology J:99582
prenatal lethality, complete penetrance J:99582
Bmp2tm1.1Mis/Bmp2tm1.2Mis
Tg(Col1a1-cre)1Bek/0
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CD-1 		abnormal bone structure J:210409
abnormal trabecular bone morphology J:210409
abnormal vascular development J:210409
abnormal vertebral column morphology J:210409
absent deltoid tuberosity J:210409
decreased bone mineral density J:210409
decreased bone mineralization J:210409
decreased bone ossification J:210409
decreased bone volume J:210409
decreased osteoblast cell number J:210409
decreased osteoclast cell number J:210409
decreased trabecular bone thickness J:210409
decreased trabecular bone volume J:210409
fragile skeleton J:210409
impaired osteoblast differentiation J:210409
short humerus J:210409
small vertebrae J:210409
vertebral fusion J:210409
Bmp2tm1.2Mis/Bmp2tm1.2Mis
involves: 129S4/SvJaeSor * 129S7/SvEvBrd 		abnormal heart development J:210409
Bmp2tm1Brd/Bmp2tm1.1Mis
involves: 129S/SvEv * C57BL/6J 		normal mortality/aging J:141834
Bmp2tm1Brd/Bmp2tm1.1Mis
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J 		normal hearing/vestibular/ear phenotype J:156945
Bmp2tm1Brd/Bmp2tm1.1Mis
Gfi1tm1(cre)Gan/Gfi1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J 		increased or absent threshold for auditory brainstem response J:156945
Bmp2tm1Brd/Bmp2tm1Brd
involves: 129S7/SvEvBrd * C57BL/6 		abnormal chorion morphology J:36213
abnormal heart development J:36213
abnormal heart position or orientation J:36213
abnormal proamniotic cavity morphology J:36213
decreased embryo size J:36213
delayed allantois development J:36213
delayed heart development J:36213
embryonic lethality, complete penetrance J:36213
incomplete embryo turning J:36213
open neural tube J:36213
Bmp2tm1Brd/Bmp2tm1Mis
involves: 129S7/SvEvBrd * C57BL/6J 		decreased body weight J:141834
decreased litter size J:141834
decreased survivor rate J:141834
exencephaly J:141834
herniated abdominal wall J:141834
incomplete rostral neuropore closure J:141834
kinked tail J:141834
long gestation period J:141834
Bmp2tm1Cjt/Bmp2tm1Cjt
Tg(Prrx1-cre)1Cjt/0
involves: C57BL/6 * SJL 		abnormal scapula morphology J:118257
syndactyly J:118257
Bmp2tm1Jfm/Bmp2tm1.1Jfm
involves: 129S4/SvJaeSor 		no abnormal phenotype detected J:99582
Bmp2tm1Jfm/Bmp2tm1Jfm
involves: 129S4/SvJaeSor 		no abnormal phenotype detected J:99582
Bmp2tm1Jfm/Bmp2tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		abnormal craniofacial bone morphology J:274818
abnormal craniofacial morphology J:274818
abnormal head shape J:274818
abnormal jaw morphology J:274818
abnormal maxillary shelf morphology J:274818
abnormal maxillary zygomatic process morphology J:274818
abnormal presphenoid bone morphology J:274818
abnormal sphenoid bone morphology J:274818
abnormal temporal bone zygomatic process morphology J:274818
abnormal tongue position J:274818
absent mandibular coronoid process J:274818
absent zygomatic bone J:274818
complete cleft palate J:274818
normal craniofacial phenotype J:274818
failure of palatal shelf elevation J:274818
mandible hypoplasia J:274818
maxilla hypoplasia J:274818
micrognathia J:274818
perinatal lethality, complete penetrance J:274818
short mandible J:274818
small mandible J:274818
small Meckel's cartilage J:274818
Bmp2tm1Jfm/Bmp2tm1Jfm
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S4/SvJaeSor 		abnormal cardiac epithelial to mesenchymal transition J:104417
abnormal cardiac jelly morphology J:104417
abnormal fetal atrioventricular canal morphology J:104417
abnormal myocardium layer morphology J:104417
embryonic growth retardation J:104417
embryonic lethality during organogenesis, complete penetrance J:104417
pericardial effusion J:104417
Bmp2tm1Vrs/Bmp2tm1Vrs
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv * C57BL/6 		abnormal heart development J:110615
absent atrioventricular cushions J:110615
cardiac edema J:110615
decreased embryo size J:110615
embryonic lethality during organogenesis, complete penetrance J:110615
pericardial effusion J:110615
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory