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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bmp4
bone morphogenetic protein 4
MGI:88180
256 phenotypes from 16 alleles in 37 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bmp4tm1.1Jlch/Bmp4+
B6.129-Bmp4tm1.1Jlch 		decreased primordial germ cell number J:108516
Bmp4tm1.1Jlch/Bmp4tm1.1Jlch
B6.129-Bmp4tm1.1Jlch 		abnormal forelimb morphology J:108516
decreased primordial germ cell number J:108516
decreased rib number J:108516
preaxial polydactyly J:108516
seminiferous tubule degeneration J:108516
short ribs J:108516
small testis J:108516
Bmp4tm1.1Jlch/Bmp4tm2Blh
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		abnormal allantois morphology J:108516
abnormal chorion morphology J:108516
abnormal forelimb morphology J:108516
anophthalmia J:108516
failure of ventral body wall closure J:108516
lethality throughout fetal growth and development, incomplete penetrance J:108516
microphthalmia J:108516
omphalocele J:108516
perimembraneous ventricular septal defect J:108516
polydactyly J:108516
postnatal lethality, incomplete penetrance J:108516
small allantois J:108516
split xiphoid process J:108516
Bmp4tm1b(EUCOMM)Hmgu/Bmp4+
C57BL/6N-Bmp4tm1b(EUCOMM)Hmgu/Bay 		abnormal eye anterior chamber depth J:211773
abnormal iris morphology J:211773
abnormal optic disk morphology J:211773
abnormal retina inner nuclear layer morphology J:211773
abnormal retina morphology J:211773
abnormal retina outer nuclear layer morphology J:211773
decreased anxiety-related response J:211773
decreased total retina thickness J:211773
eyelids fail to open J:211773
hyperactivity J:211773
increased grip strength J:211773
microphthalmia J:211773
Bmp4tm1b(EUCOMM)Hmgu/Bmp4tm1b(EUCOMM)Hmgu
C57BL/6N-Bmp4tm1b(EUCOMM)Hmgu/Bay 		abnormal allantois morphology J:211773
abnormal embryo development J:211773
abnormal embryo size J:211773
abnormal embryo turning J:211773
abnormal forebrain development J:211773
abnormal heart morphology J:211773
abnormal hindbrain development J:211773
abnormal midbrain development J:211773
abnormal neural tube closure J:211773
embryonic growth retardation J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Bmp4tm1Blh/Bmp4+
B6.129S2-Bmp4tm1Blh 		abnormal anterior eye segment morphology J:82877
abnormal canal of Schlemm morphology J:82877
abnormal cornea morphology J:82877
abnormal eye electrophysiology J:82877
abnormal eye morphology J:82877
abnormal eye size J:42445
abnormal fertility/fecundity J:118380
abnormal iridocorneal angle J:82877
abnormal line of Schwalbe morphology J:82877
abnormal male reproductive system morphology J:42445
abnormal optic disk morphology J:82877
abnormal optic nerve morphology J:82877
abnormal organ of Corti morphology J:118380
abnormal placement of pupils J:82877
abnormal posterior eye segment morphology J:82877
abnormal prostate gland anterior lobe morphology J:42445
abnormal retina blood vessel pattern J:82877
abnormal retina morphology J:82877
abnormal retina photoreceptor layer morphology J:82877
abnormal seminiferous tubule morphology J:42445
abnormal sensory neuron innervation pattern J:118380
abnormal vestibulocollic reflex J:118380
abnormal vitreous body morphology J:82877
absent optic nerve J:82877
absent Schlemm's canal J:82877
absent trabecular meshwork J:82877
anophthalmia J:42445
anterior cortical cataract J:82877
anterior iris synechia J:82877
anterior subcapsular cataract J:82877
cataract J:82877
circling J:118380
cornea opacity J:82877
decreased cornea thickness J:82877
decreased litter size J:118380
decreased vestibular hair cell stereocilia number J:118380
hydronephrosis J:42445
hypoplastic trabecular meshwork J:82877
impaired hearing J:118380
increased opacity of vitreous body J:82877
increased or absent threshold for auditory brainstem response J:118380
iris hypoplasia J:82877
irregularly shaped pupil J:82877
kidney atrophy J:42445
kidney cyst J:42445
microphthalmia J:42445
ocular hypertension J:82877
perinatal lethality, incomplete penetrance J:42445
persistence of hyaloid vascular system J:82877
polydactyly J:42445
reduced female fertility J:118380
retina detachment J:82877
short frontal bone J:42445
short nasal bone J:42445
single kidney J:42445
thin retina ganglion layer J:82877
thin retina inner nuclear layer J:82877
Bmp4tm1Blh/Bmp4+
involves: 129S2/SvPas * 129S6/SvEvTac 		abnormal eye morphology J:82877
abnormal iris morphology J:82877
decreased primordial germ cell number J:53311
persistence of hyaloid vascular system J:82877
Bmp4tm1Blh/Bmp4+
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss 		normal behavior/neurological phenotype J:136636
Bmp4tm1Blh/Bmp4+
involves: 129S2/SvPas * BALB/cJ 		persistence of hyaloid vascular system J:82877
Bmp4tm1Blh/Bmp4+
involves: 129S2/SvPas * C3Hf/HeA * C57BL/LiA 		abnormal anterior eye segment morphology J:82877
abnormal iridocorneal angle J:82877
buphthalmos J:82877
mydriasis J:82877
Bmp4tm1Blh/Bmp4+
involves: 129S2/SvPas * C57BL/6 		abnormal ear development J:159227
abnormal lateral semicircular canal morphology J:159227
abnormal renal glomerulus morphology J:173500
absent lateral semicircular canal J:159227
circling J:159227
decreased body weight J:173500
decreased lateral semicircular canal size J:159227
normal hearing/vestibular/ear phenotype J:159227
increased circulating glucose level J:173500
Bmp4tm1Blh/Bmp4+
involves: 129S2/SvPas * C57BL/6 * CBA 		abnormal lateral semicircular canal morphology J:159227
circling J:159227
decreased primordial germ cell number J:53311, J:199855
Bmp4tm1Blh/Bmp4+
involves: 129S2/SvPas * CAST/Ei 		cataract J:82877
Bmp4tm1Blh/Bmp4+
Tg(Prdm14-Venus)1Sait/0
involves: 129S2/SvPas 		decreased primordial germ cell number J:138571
Bmp4tm1Blh/Bmp4tm1Blh
129S2/SvPas-Bmp4tm1Blh 		abnormal extraembryonic mesoderm development J:28717
abnormal visceral yolk sac morphology J:28717
absent visceral yolk sac blood islands J:28717
embryonic lethality between implantation and somite formation, complete penetrance J:28717
failure of primitive streak formation J:28717
Bmp4tm1Blh/Bmp4tm1Blh
B6.129S2-Bmp4tm1Blh 		abnormal extraembryonic mesoderm development J:28717
abnormal visceral yolk sac morphology J:28717
absent visceral yolk sac blood islands J:28717
decreased erythrocyte cell number J:28717
embryonic lethality between implantation and somite formation, complete penetrance J:28717
failure of primitive streak formation J:28717
Bmp4tm1Blh/Bmp4tm1Blh
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss 		abnormal amniotic cavity morphology J:79391
abnormal heart looping J:79391
abnormal lateral plate mesoderm morphology J:79391
abnormal mesoderm development J:79391
abnormal posterior primitive streak morphology J:79391
abnormal primitive node morphology J:79391
Bmp4tm1Blh/Bmp4tm1Blh
involves: 129S2/SvPas * Black Swiss 		abnormal lens induction J:51570
absent allantois J:53311
absent primordial germ cells J:53311
absent Rathke's pouch J:50517
embryonic growth retardation J:51570, J:53311
embryonic lethality during organogenesis, complete penetrance J:51570
Bmp4tm1Blh/Bmp4tm1Blh
involves: 129S2/SvPas * C57BL/6 		abnormal extraembryonic mesoderm development J:28717
abnormal rostral-caudal axis patterning J:28717
abnormal visceral yolk sac mesenchyme morphology J:28717
abnormal visceral yolk sac morphology J:28717
absent visceral yolk sac blood islands J:28717
embryonic growth retardation J:28717
embryonic lethality, complete penetrance J:28717
Bmp4tm1Blh/Bmp4tm1Blh
involves: 129S2/SvPas * C57BL/6 * CBA 		absent allantois J:53311
absent primordial germ cells J:53311
embryonic growth retardation J:53311
prenatal lethality, complete penetrance J:53311
Bmp4tm1Blh/Bmp4tm1Blh
involves: 129S2/SvPas * ICR 		embryonic growth retardation J:28717
embryonic lethality during organogenesis, complete penetrance J:28717
Bmp4tm1Blh/Bmp4tm3.1Blh
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss 		abnormal eye morphology J:75136
eyelids fail to open J:75136
perinatal lethality, complete penetrance J:75136
Bmp4tm1Blh/Bmp4tm3.1Blh
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR 		abnormal eye morphology J:86001
normal cardiovascular system phenotype J:86001
ostium primum atrial septal defect J:86001
partial atrioventricular septal defect J:86001
postnatal lethality, complete penetrance J:86001
Bmp4tm1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR 		abnormal atrioventricular cushion morphology J:86001
common atrioventricular valve J:86001
complete atrioventricular septal defect J:86001
double outlet right ventricle J:86001
perinatal lethality, complete penetrance J:86001
Bmp4tm1Blh/Bmp4tm4Blh
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL 		abnormal semicircular canal morphology J:136636
Bmp4tm1Blh/Bmp4tm4Blh
Foxg1tm1(cre)Skm/Foxg1+
involves: 129 * Black Swiss * C57BL/6 * SJL 		abnormal endolymphatic duct morphology J:136636
abnormal scala media morphology J:136636
abnormal semicircular canal ampulla morphology J:136636
abnormal semicircular canal morphology J:136636
abnormal utricle morphology J:136636
abnormal vestibular saccule morphology J:136636
absent semicircular canals J:136636
Bmp4tm1Blh/Bmp4tm4Blh
Tg(Pax2-cre)1Dje/0
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL 		abnormal inner ear morphology J:136636
abnormal semicircular canal morphology J:136636
abnormal utricle morphology J:136636
abnormal vestibular saccule morphology J:136636
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd 		abnormal aortic arch and aortic arch branch attachment J:89237
abnormal conotruncal ridge morphology J:89237
abnormal heart development J:89237
abnormal pharyngeal arch artery morphology J:89237
abnormal pulmonary artery morphology J:89237
aortopulmonary window J:89237
conotruncal ridge hypoplasia J:89237
embryonic lethality during organogenesis, incomplete penetrance J:89237
hydrops fetalis J:89237
interrupted aortic arch, type b J:89237
pericardial effusion J:89237
perimembraneous ventricular septal defect J:89237
persistent truncus arteriosus J:89237
semilunar valve hypoplasia J:89237
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor 		conotruncal ridge hypoplasia J:89237
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J 		abnormal mandible morphology J:181229
impaired osteoblast differentiation J:181229
large anterior fontanelle J:181229
small interparietal bone J:181229
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor 		abnormal cardiac outflow tract development J:169047
abnormal heart and great artery attachment J:169047
abnormal truncus arteriosus septation J:169047
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL 		polydactyly J:118257
Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4tm2(tetO-Bmp4,lacZ)Jfm
involves: 129S4/SvJaeSor 		abnormal cardiac mesenchyme morphology J:181229
abnormal head mesenchyme morphology J:181229
Bmp4tm2Blh/Bmp4+
B6.129S6-Bmp4tm2Blh 		abnormal vertebral spinous process morphology J:108516
anophthalmia J:108516
cervical vertebral fusion J:108516
decreased rib number J:108516
enlarged kidney J:108516
microphthalmia J:108516
perimembraneous ventricular septal defect J:108516
polycystic kidney J:108516
postnatal lethality, incomplete penetrance J:108516
short ribs J:108516
thoracic vertebral fusion J:108516
Bmp4tm2Blh/Bmp4+
involves: 129S6/SvEvTac * Black Swiss 		decreased primordial germ cell number J:53311
Bmp4tm2Blh/Bmp4+
involves: 129S6/SvEvTac * Black Swiss * C57BL/6J 		abnormal kidney development J:61482
abnormal kidney mesenchyme morphology J:61482
abnormal metanephric mesenchyme morphology J:82895
abnormal nephrogenic zone morphology J:61482, J:82895
abnormal renal/urinary system morphology J:61482
abnormal ureter development J:61482, J:82895
abnormal ureter morphology J:61482
abnormal ureter smooth muscle morphology J:82895
abnormal ureteral orifice morphology J:61482
abnormal ureteric bud elongation J:61482
abnormal ureterovesical junction morphology J:61482
abnormal Wolffian duct morphology J:61482
bifid ureter J:61482
dilated kidney calyx J:61482
dilated ureter J:61482
duplex kidney J:61482
ectopic ureter J:61482
ectopic ureteric bud J:61482
hydronephrosis J:61482
hydroureter J:61482
increased metanephric mesenchyme apoptosis J:82895
kidney cyst J:61482
renal hypoplasia J:61482
small kidney J:61482
Bmp4tm2Blh/Bmp4+
involves: 129S6/SvEvTac * ICR 		abnormal angiogenesis J:112335
abnormal artery morphology J:112335
abnormal heart right ventricle pressure J:112335
abnormal vascular endothelial cell physiology J:112335
abnormal vascular smooth muscle morphology J:112335
heart right ventricle hypertrophy J:112335
Bmp4tm2Blh/Bmp4tm2Blh
involves: 129S6/SvEvTac * Black Swiss 		abnormal foregut morphology J:71204
abnormal liver bud morphology J:71204
absent allantois J:53311
absent primordial germ cells J:53311
delayed hepatic development J:71204
embryonic growth retardation J:53311
embryonic lethality during organogenesis, complete penetrance J:71204
Bmp4tm3.1Blh/Bmp4+
Tg(Sftpc-cre)1Blh/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal lung morphology J:106392
abnormal respiratory system physiology J:106392
Bmp4tm3.1Blh/Bmp4tm3.1Blh
involves: 129S6/SvEvTac * Black Swiss 		abnormal eye morphology J:75136
Bmp4tm3.1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * ICR 		atrial septal defect J:86001
normal cardiovascular system phenotype J:86001
perinatal lethality J:86001
Bmp4tm3Blh/Bmp4+
involves: 129S6/SvEvTac 		prenatal lethality, incomplete penetrance J:83123
Bmp4tm3Blh/Bmp4+
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S6/SvEvTac 		prenatal lethality, incomplete penetrance J:83123
Bmp4tm3Blh/Bmp4tm3Blh
involves: 129S6/SvEvTac 		abnormal eye development J:83123
embryonic lethality during organogenesis, incomplete penetrance J:83123
Bmp4tm3Blh/Bmp4tm3Blh
involves: 129S6/SvEvTac * Black Swiss 		abnormal eye morphology J:75136
circling J:75136
eyelids fail to open J:75136
postnatal lethality J:75136
Bmp4tm3Blh/Bmp4tm3Blh
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal eye development J:83123
abnormal face development J:83123
abnormal snout morphology J:83123
embryonic lethality during organogenesis, complete penetrance J:83123
normal nervous system phenotype J:83123
retrognathia J:83123
Bmp4tm4Blh/Bmp4tm4Blh
Isl1tm1(cre)Sev/Isl1+
involves: 129 * 129S6/SvEvTac 		abnormal embryonic cloaca development J:192045
abnormal external female genitalia morphology J:192045
abnormal fibula morphology J:192045
abnormal hindlimb bud morphology J:192045
abnormal limb development J:192045
abnormal renal/urinary system morphology J:192045
absent urinary bladder J:192045
anal stenosis J:192045
external male genitalia hypoplasia J:192045
renal hypoplasia J:192045
sirenomelia J:192045
Bmp4tm5.1Bhr/Bmp4tm2.1Blh
involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster 		embryonic growth retardation J:159629
prenatal lethality, complete penetrance J:159629
Bmp4tm5.1Bhr/Bmp4tm5.1Bhr
involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster 		embryonic growth retardation J:159629
prenatal lethality, complete penetrance J:159629
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(CAG-Bmp4,-EGFP)1Ypc/0
involves: C57BL/6J * CBA/J * CD-1 		abnormal jaw morphology J:214763
abnormal secondary palate development J:214763
abnormal temporomandibular joint morphology J:214763
absent mandibular angle J:214763
absent mandibular condyloid process J:214763
absent mandibular coronoid process J:214763
absent outer ear J:214763
agnathia J:214763
cleft palate J:214763
decreased palatal shelf size J:214763
enhanced osteoblast differentiation J:214763
eyelids open at birth J:214763
frontal bone hypoplasia J:214763
mandible hypoplasia J:214763
maxilla hypoplasia J:214763
nasal bone hypoplasia J:214763
palatal shelf fusion with tongue or mandible J:214763
short snout J:214763
syngnathia J:214763
Osr2tm2(cre)Jian/Osr2+
Tg(CAG-Bmp4,-EGFP)1Ypc/0
involves: 129S1/Sv * C57BL/6J * CD-1 		cleft palate J:214763
palatal shelf fusion with tongue or mandible J:214763
palatal shelves fail to meet at midline J:214763
Tg(Actb-GFP,-Bmp4)1Csk/0
Tg(CAG-cre/Esr1*)67Csk/0
C57BL/6-Tg(Actb-GFP,-Bmp4)1Csk Tg(CAG-cre/Esr1*)67Csk 		abnormal renal glomerulus morphology J:173500
albuminuria J:173500
glomerulosclerosis J:173500
Tg(Eno2-Bmp4)3Jake/0
involves: BALB/c * C57BL/6 		abnormal gait J:93682
abnormal motor capabilities/coordination/movement J:93682
abnormal muscle fiber morphology J:93682
abnormal muscle morphology J:93682
abnormal radial glial cell morphology J:82446
abnormal trabecular bone morphology J:93682
decreased oligodendrocyte number J:82446
ectopic bone J:93682
increased astrocyte number J:82446
kyphoscoliosis J:93682
kyphosis J:93682
limb grasping J:93682
scoliosis J:93682
Tg(Krt14-Bmp4)#Jake/0
involves: BALB/c * C57BL/6 		normal limbs/digits/tail phenotype J:78767
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory