Smarca4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
MGI:88192

31 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Rb1^tm1Tyj/Rb1⁺ Smarca4^tm1Mag/Smarca4⁺ involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1	increased pituitary gland tumor incidence	J:132091
	premature death	J:132091
Smarca2^tm1Mya/Smarca2⁺ Smarca4^tm1.2Pcn/Smarca4^tm1.1Pcn Tg(Myh11-cre,-EGFP)2Mik/0 involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal small intestine morphology	J:172661
	decreased colon length	J:172661
	decreased small intestine length	J:172661
	enlarged cecum	J:172661
	megacolon	J:172661
Smarca2^tm1Mya/Smarca2^tm1Mya Smarca4^tm1.1Pcn/Smarca4⁺ involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal muscle physiology	J:172661
	normal digestive/alimentary phenotype	J:172661
Smarca2^tm1Mya/Smarca2^tm1Mya Smarca4^tm1.2Pcn/Smarca4^tm1.1Pcn Tg(Myh11-cre,-EGFP)2Mik/0 involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal digestive system morphology	J:172661
	abnormal intestinal smooth muscle morphology	J:172661
	abnormal intestine morphology	J:172661
	abnormal muscle physiology	J:172661
	abnormal small intestine morphology	J:172661
	abnormal urinary bladder morphology	J:172661
	impaired smooth muscle contractility	J:172661
	postnatal lethality, complete penetrance	J:172661
Smarca2^tm1Mya/Smarca2^tm1Mya Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Tg(KRT14-cre/ERT2)1Ipc/? involves: 129S2/SvPas	abnormal epidermis stratum corneum morphology	J:101729
	abnormal epidermis stratum granulosum morphology	J:101729
	abnormal skin morphology	J:101729
	enlarged spinous cells	J:101729
	impaired skin barrier function	J:101729
Smarca2^tm1Mya/Smarca2^tm1Mya Smarca4^tm1Mag/Smarca4⁺ involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1	increased hemangiosarcoma incidence	J:132091
	increased mammary gland tumor incidence	J:132091
Smarca4^mos6/Smarca4⁺ Sox10^tm1Weg/Sox10⁺ involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	abnormal melanoblast morphology	J:241206
	belly spot	J:241206
	head spot	J:241206
Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	abnormal semilunar valve morphology	J:226941
Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Tg(Lck-cre)1Cwi/0 Tg(LCKprBCL2L1)12Sjk/0 Not Specified	abnormal T cell morphology	J:144072
	decreased double-positive T cell number	J:144072
	increased double-negative T cell number	J:144072
	increased thymocyte number	J:144072
Smarca4^tm1.2Pcn/Smarca4^tm1Mag Tg(Lck-cre)1Cwi/? Tg(LCKprBCL2)36Sjk/? involves: 129S/Sv * C57BL/6 * DBA/2	arrested T cell differentiation	J:85191
Smarca4^tm1.2Pcn/Smarca4^tm1Tich Tg(Lck-cre)1Cwi/0 Tg(LCKprBCL2L1)12Sjk/0 involves: 129	abnormal T cell morphology	J:144072
	decreased double-positive T cell number	J:144072
	increased double-negative T cell number	J:144072
	increased thymocyte number	J:144072

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24