Btk Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Btk
Bruton agammaglobulinemia tyrosine kinase
MGI:88216

47 phenotypes from 9 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Btk^m1Anu/Btk^m1Anu involves: BXSB/MpJ * C57BL/6JAnu * SB/Le	decreased B cell number	J:104190
Btk^m2Anu/Btk^m2Anu C57BL/6NCrlAnu-Btk^m2Anu	increased IgM level	J:104190
Btk^m2Anu/Btk^m2Anu C57BL/6NCrlAnu-Btk^m2Anu	increased immature B cell number	J:104190
Btk^{tm1a(EUCOMM)Hmgu}/Y C57BL/6N-Btk^{tm1a(EUCOMM)Hmgu}/Ics	decreased body weight	J:165965
	increased CD4-positive, alpha-beta T cell number	J:165965
Btk^tm1Gsv/Y involves: 129P2/OlaHsd * C57BL/6	abnormal B cell calcium ion homeostasis	J:94768
	abnormal B cell differentiation	J:35769
	abnormal humoral immune response	J:120989
	abnormal immune system physiology	J:35769
	absent B-1a cells	J:35769
	absent mature B cells	J:35769
	decreased B cell number	J:35769
	decreased IgG3 level	J:35769
	decreased IgM level	J:35769
	decreased immature B cell number	J:35769
	decreased immunoglobulin level	J:120989
Btk^tm1Gsv/Btk⁺ involves: 129P2/OlaHsd * C57BL/6	absent B-1a cells	J:35769
	decreased B cell number	J:35769
	decreased mature B cell number	J:35769
Btk^tm1Witt/Btk^tm1Wk involves: 129S4/SvJae * 129X1/SvJ	normal immune system phenotype	J:104167
Btk^tm1Wk/Btk^tm1Wk involves: 129S4/SvJae * C57BL/6	abnormal B cell activation	J:28968
	abnormal B cell differentiation	J:28968
	abnormal lymph node germinal center morphology	J:82298
	decreased B cell proliferation	J:82298
	decreased IgG3 level	J:28968, J:82298
	decreased IgM level	J:28968, J:82298
	decreased mature B cell number	J:28968, J:82298
	decreased spleen germinal center number	J:82298
	decreased spleen germinal center size	J:82298
	increased pro-B cell number	J:28968
Btk^tm1Wk/Btk^tm1Wk Tg(IGH-Btk)1Witt/0 involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6	decreased B cell proliferation	J:82430
Btk^vila/Btk^vila C57BL/6JAnu-Btk^vila/AnuApb	abnormal leukocyte morphology	J:104190
	decreased B cell number	J:104190
	decreased IgD level	J:104190
	increased IgE level	J:104190
	increased IgG level	J:104190
Btk^xid/Y CBA/HN-Btk^xid	decreased B cell number	J:81429
	decreased B cell proliferation	J:81429
	decreased splenocyte number	J:81429
Btk^xid/? involves: BALB/c * CBA/N	decreased B cell proliferation	J:108696
	decreased B-1 B cell number	J:108696
	decreased IgG3 level	J:108696
	decreased IgM level	J:108696
	decreased mature B cell number	J:108696
Btk^xid/Y involves: CBA/HN * DBA/2N	decreased B cell number	J:81429
	decreased B cell proliferation	J:81429
	spleen hypoplasia	J:81429
Btk^xid/Btk^xid B6.CBA-Btk^xid	decreased transitional stage B cell number	J:145687
Btk^xid/Btk^xid CBA/CaHN-Btk^xid/J	abnormal macrophage physiology	J:92639
	abnormal neutrophil physiology	J:92639
	decreased acute inflammation	J:92639
	decreased follicular B cell number	J:69477
	decreased neutrophil cell number	J:92639
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:92639
	impaired myelopoiesis	J:92639
	impaired neutrophil phagocytosis	J:92639
	increased susceptibility to bacterial infection induced morbidity/mortality	J:128518
	increased susceptibility to induced colitis	J:92639
Btk^xid/Btk^xid CBA/HN-Btk^xid	abnormal bone marrow cell number	J:7981
	abnormal lymphopoiesis	J:7981
	abnormal pre-B cell morphology	J:7981
	autoimmune response	J:125114
	decreased B cell number	J:81429
	decreased B cell proliferation	J:81429
	decreased splenocyte number	J:81429
Btk^xid/Btk^xid involves: C57BL/6 * CBA	normal immune system phenotype	J:113083
Btk^xid/Btk^xid involves: CBA/HN * DBA/2N	abnormal B cell physiology	J:81429
	abnormal B cell proliferation	J:81429
	decreased B cell number	J:81429
	spleen hypoplasia	J:81429
Btk^xid/? Tg(IGH-Btk)1Witt/0 involves: BALB/c * C3H * C57BL/6 * CBA/N	decreased B cell proliferation	J:108696
	decreased B-1 B cell number	J:108696
	decreased IgG3 level	J:108696
	decreased IgM level	J:108696
Btk^xid/? Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt involves: BALB/c * C3H * C57BL/6 * CBA/N	decreased B cell proliferation	J:108696
	decreased B-1 B cell number	J:108696
	decreased IgG3 level	J:108696
	decreased IgM level	J:108696

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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