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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Btk
Bruton agammaglobulinemia tyrosine kinase
MGI:88216
37 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Blnktm1Achn/Blnk+
Btktm1Wk/Btktm1Wk
Tg(IGH-Btk)1Witt/0
involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6 		abnormal B cell physiology J:82430
decreased B cell proliferation J:82430
Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal B cell differentiation J:94768
decreased IgG3 level J:94768
decreased IgM level J:94768
decreased immature B cell number J:94768
decreased immunoglobulin level J:94768
decreased mature B cell number J:94768
increased B cell derived lymphoma incidence J:94768
Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB 		abnormal B cell differentiation J:94768
decreased IgG3 level J:94768
decreased IgM level J:94768
decreased immunoglobulin level J:94768
normal neoplasm J:94768
Blnktm1Pjln/Blnktm1Pjln
Btktm1Wk/Btktm1Wk
involves: 129S4/SvJae * BALB/c * C57BL/6 		arrested B cell differentiation J:70406
Btkm1Anu/Btkm1Anu
X/Yaa
involves: BXSB/MpJ * C57BL/6JAnu * SB/Le 		decreased B cell number J:104190
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
involves: 129P2/OlaHsd * C57BL/6 * FVB 		abnormal lymphocyte cell number J:120989
abnormal pre-B cell morphology J:120989
absent B-1a cells J:120989
decreased B cell apoptosis J:120989
decreased B cell number J:120989
decreased immunoglobulin level J:120989
normal immune system phenotype J:94768
Btktm1Wk/Btktm1Wk
Cd40tm1Geha/Cd40tm1Geha
involves: 129S4/SvJae * C57BL/6 		abnormal humoral immune response J:82298
absent lymph node germinal center J:82298
absent spleen germinal center J:82298
decreased B cell number J:82298
decreased B cell proliferation J:82298
decreased IgA level J:82298
decreased IgG2a level J:82298
decreased IgG2b level J:82298
decreased IgG3 level J:82298
decreased IgM level J:82298
decreased mature B cell number J:82298
Btktm1Wk/Btktm1Wk
Tectm1Welm/Tectm1Welm
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell differentiation J:66080
abnormal humoral immune response J:66080
abnormal platelet physiology J:86448
abnormal spleen marginal zone morphology J:66080
abnormal spleen morphology J:66080
abnormal spleen white pulp morphology J:66080
decreased B cell number J:66080
decreased B cell proliferation J:66080
decreased IgG2a level J:66080
decreased IgG3 level J:66080
decreased IgM level J:66080
decreased immunoglobulin level J:66080
decreased platelet aggregation J:86448
increased pre-B cell number J:66080
Btkxid/Btkxid
Ikzf3tm1Kge/Ikzf3tm1Kge
involves: 129S4/SvJae * CBA/CaHN 		decreased follicular B cell number J:69477
Btkxid/Y
Ikzf3tm1Kge/Ikzf3tm1Kge
involves: 129S4/SvJae * CBA/CaHN 		decreased follicular B cell number J:69477
Btkxid/?
Ptpn6me/Ptpn6me
involves: C57BL/6J * CBA/N * NFS 		abnormal skin condition J:30994
absent limbs J:30994
decreased body weight J:30994
increased autoantibody level J:30994
increased IgM level J:30994
increased splenocyte proliferation J:30994
premature death J:30994
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory