About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		C3
complement component 3
MGI:88227
89 phenotypes from 3 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
C3tm1Crr/C3tm1Crr
B6.129S4-C3tm1Crr 		abnormal blastocyst morphology J:150898
abnormal blood homeostasis J:113463
abnormal dendritic spine morphology J:224676
abnormal female reproductive system physiology J:150898
abnormal hippocampus CA3 region morphology J:224676
abnormal inflammatory response J:113463
abnormal neutrophil morphology J:113463
abnormal spatial working memory J:224676
abnormal synaptic plasticity J:224676
abnormal synaptic vesicle number J:224676
brain inflammation J:123658
decreased anxiety-related response J:224676
decreased cerebral infarct size J:123658
decreased fetal weight J:150898
decreased placental labyrinth size J:150898
decreased spongiotrophoblast size J:150898
decreased susceptibility to autoimmune hemolytic anemia J:145432
enhanced contextual conditioning behavior J:224676
enhanced long-term potentiation J:224676
enhanced paired-pulse facilitation J:224676
enhanced spatial learning J:224676
impaired embryo implantation J:150898
increased neuron number J:224676
prolonged estrous cycle J:150898
small placenta J:150898
C3tm1Crr/C3tm1Crr
B6;129S4-C3tm1Crr/J 		abnormal c-wave shape J:214214
abnormal eye electrophysiology J:136745
abnormal retina horizontal cell morphology J:214214
abnormal retina rod bipolar cell morphology J:214214
decreased b-wave amplitude J:214214
decreased circulating free fatty acids level J:214214
decreased susceptibility to Coronaviridae infection J:286325
increased susceptibility to bacterial infection J:136745
normal vision/eye phenotype J:136745
C3tm1Crr/C3tm1Crr
involves: 129S4/SvJae 		abnormal blood coagulation J:44715
decreased susceptibility to alcohol-induced hepatic steatosis J:128218
decreased susceptibility to injury J:128218
decreased urine albumin level J:44715
glomerulonephritis J:44715
C3tm1Crr/C3tm1Crr
involves: 129S4/SvJae * C57BL/6 		abnormal cell-mediated immunity J:30152
abnormal enzyme/coenzyme level J:152533
abnormal humoral immune response J:64282
abnormal immune system morphology J:44240
abnormal immune system physiology J:44240
abnormal induced morbidity/mortality J:152533
abnormal intestine morphology J:78613
abnormal liver morphology J:152533
abnormal liver physiology J:152533
abnormal mast cell physiology J:44240
abnormal spleen germinal center morphology J:64282
abnormal tumor necrosis factor level J:44240
decreased circulating alanine transaminase level J:152533
decreased circulating interleukin-6 level J:152533, J:166640
decreased circulating tumor necrosis factor level J:152533
decreased hepatocyte proliferation J:152533
decreased mast cell number J:44240
decreased neutrophil cell number J:44240
decreased osteoclast cell number J:166640
decreased spleen germinal center number J:64282
decreased spleen germinal center size J:64282
decreased susceptibility to injury J:120567
decreased vascular permeability J:78613
enhanced central nervous system regeneration J:112353
focal hepatic necrosis J:152533
hepatic steatosis J:152533
normal immune system phenotype J:64282
impaired liver regeneration J:152533
increased circulating alanine transaminase level J:152533
increased circulating bilirubin level J:152533
increased susceptibility to bacterial infection J:30152, J:44240
increased susceptibility to bacterial infection induced morbidity/mortality J:205353
increased susceptibility to induced morbidity/mortality J:44240
liver inflammation J:30152
C3tm1Hrc/C3tm1Hrc
B6.129-C3tm1Hrc 		impaired complement alternative pathway J:177350
impaired liver regeneration J:91917
C3tm1Hrc/C3tm1Hrc
either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129X1/SvJ * C57BL/6) 		increased susceptibility to bacterial infection J:56193
C3tm1Hrc/C3tm1Hrc
involves: 129 		abnormal intestinal lipid absorption J:87945
decreased body weight J:87945
decreased circulating insulin level J:87945
decreased circulating leptin level J:87945
decreased total body fat amount J:87945
increased circulating free fatty acids level J:87945
increased triglyceride level J:87945
polyphagia J:87945
C3tm1Hrc/C3tm1Hrc
involves: 129/Sv * C57BL/6 		abnormal energy expenditure J:58966, J:60633
abnormal glucose homeostasis J:58966, J:60633
abnormal lipid homeostasis J:58966, J:60633
decreased body weight J:60633
decreased circulating glucose level J:58966, J:60633
decreased circulating insulin level J:60633
decreased circulating leptin level J:58966, J:60633
decreased circulating triglyceride level J:60633
decreased total body fat amount J:58966, J:60633
decreased white adipose tissue amount J:60633
increased brown adipose tissue amount J:58966
increased circulating free fatty acids level J:58966, J:60633
increased triglyceride level J:58966
polyphagia J:58966, J:60633
C3tm1Pkna/C3tm1Pkna
D1.129P2-C3tm1Pkna 		decreased susceptibility to induced arthritis J:88872
C3tm1Pkna/C3tm1Pkna
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:45857
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory