C3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

C3
complement component 3
MGI:88227

41 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
C3^tm1Crr/C3^tm1Crr C4b^tm1Crr/C4b^tm1Crr Fas^lpr/Fas^lpr involves: 129S4/SvJae * C57BL/6 * MRL	abnormal immune system physiology	J:127292
	abnormal kidney morphology	J:127292
	abnormal renal glomerulus morphology	J:127292
	enlarged cervical lymph nodes	J:127292
	enlarged spleen	J:127292
	increased anti-double stranded DNA antibody level	J:127292
	increased anti-nuclear antigen antibody level	J:127292
C3^tm1Crr/C3^tm1Crr Cd59a^tm1Bpm/Cd59a^tm1Bpm B6.129-Cd59a^tm1Bpm C3^tm1Crr	increased T cell proliferation	J:122201
C3^tm1Crr/C3^tm1Crr Del(2Cd59b-Cd59a)1Jha/Del(2Cd59b-Cd59a)1Jha involves: 129/Sv * 129S4/SvJae * C57BL/6	normal hematopoietic system phenotype	J:170754
C3^tm1Crr/C3^tm1Crr Dysf^tm1Kcam/Dysf^tm1Kcam B6.129-Dysf^tm1Kcam C3^tm1Crr	muscle weakness	J:171870
C3^tm1Crr/C3^tm1Crr Fas^lpr/Fas^lpr involves: 129S4/SvJae * C57BL/6 * MRL	abnormal renal glomerulus morphology	J:127292
	decreased susceptibility to autoimmune disorder	J:127292
	normal immune system phenotype	J:127292
C3^tm1Crr/C3^tm1Crr Fcer1g^tm1Rav/Fcer1g^tm1Rav Tg(Ins2-TFRC/OVA)296Wehi/0 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	decreased susceptibility to autoimmune diabetes	J:122114
C3^tm1Crr/C3^tm1Crr Tg(Ins2-TFRC/OVA)296Wehi/0 involves: 129S4/SvJae * C57BL/6	decreased susceptibility to autoimmune diabetes	J:122114
	increased interferon-gamma secretion	J:122114
	increased T cell proliferation	J:122114
	insulitis	J:122114
	normal mortality/aging	J:122114
C3^tm1Crr/C3^tm1Crr Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/? involves: 129S4/SvJae * C57BL/6	amyloid beta deposits	J:135902
	increased microglial cell activation	J:135902
	loss of hippocampal neurons	J:135902
C3^tm1Hrc/C3^tm1Hrc Cd55^tm1Song/Cd55^tm1Song Cr1l^tm1Hmo/Cr1l^tm1Hmo involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ	abnormal platelet physiology	J:138410
C3^tm1Hrc/C3^tm1Hrc Cd55^tm1Song/Cd55^tm1Song Cr1l^tm1Hmo/Cr1l^tm1Hmo Vsig4^tm1Gne/Vsig4^tm1Gne involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N	abnormal platelet physiology	J:138410
C3^tm1Hrc/C3^tm1Hrc Cfh^tm1.1Song/Cfh^tm1.1Song involves: 129 * C57BL/6	no abnormal phenotype detected	J:240426
C3^tm1Hrc/C3^tm1Hrc Cr1l^tm1Hmo/Cr1l^tm1Hmo involves: 129/Sv * 129X1/SvJ * C57BL/6	abnormal complement pathway	J:76578
	normal mortality/aging	J:59432
	normal reproductive system phenotype	J:86999
C3^tm1Hrc/C3^tm1Hrc Lama2^dy/Lama2^dy either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)	abnormal physical strength	J:102959
	abnormal skeletal muscle morphology	J:102959
	decreased IgM level	J:102959
	dystrophic muscle	J:102959
	extended life span	J:102959
	increased body weight	J:102959
	increased IgG level	J:102959
	increased IgM level	J:102959
	skeletal muscle interstitial fibrosis	J:102959
C3^tm1Hrc/C3^tm1Hrc Lep^ob/Lep^ob involves: 129 * C57BL/6	abnormal energy expenditure	J:80546
	abnormal glucose homeostasis	J:80546
	abnormal lipid homeostasis	J:80546
	abnormal oxygen consumption	J:80546
	decreased body weight	J:80546
	decreased circulating insulin level	J:80546
	increased circulating free fatty acids level	J:80546
	increased triglyceride level	J:80546
	polyphagia	J:80546
C3^tm1Hrc/C3^tm1Hrc Vsig4^tm1Gne/Vsig4^tm1Gne involves: 129/Sv * C57BL/6N	normal immune system phenotype	J:138691

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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