C4b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

C4b
complement C4B (Chido blood group)
MGI:88228

27 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
C4b^em1(IMPC)H/C4b^em1(IMPC)H C57BL/6NTac-C4b^em1(IMPC)H/H	decreased lean body mass	J:211773
C4b^em1(IMPC)H/C4b^em1(IMPC)H C57BL/6NTac-C4b^em1(IMPC)H/H	increased freezing behavior	J:211773
C4b^tm1Crr/C4b^tm1Crr involves: 129S4/SvJae	abnormal blood coagulation	J:44715
	decreased susceptibility to Coronaviridae infection	J:286325
	glomerulonephritis	J:44715
C4b^tm1Crr/C4b^tm1Crr involves: 129S4/SvJae * C57BL/6	abnormal humoral immune response	J:64282
	abnormal intestine morphology	J:78613
	abnormal spleen germinal center morphology	J:64282
	decreased spleen germinal center number	J:64282
	decreased spleen germinal center size	J:64282
	decreased susceptibility to bacterial infection	J:30152
	decreased vascular permeability	J:78613
	normal homeostasis/metabolism phenotype	J:120567
	normal immune system phenotype	J:30152, J:64282
	increased susceptibility to bacterial infection induced morbidity/mortality	J:30152
	increased susceptibility to induced morbidity/mortality	J:44240
	liver inflammation	J:30152
C4b^tm1Crr/C4b^tm1Crr involves: 129S4/SvJae * C57BL/6J	abnormal immune system physiology	J:111811
	abnormal renal glomerulus morphology	J:111811
	glomerulonephritis	J:111811
	increased anti-double stranded DNA antibody level	J:111811
	increased anti-nuclear antigen antibody level	J:111811
	increased anti-single stranded DNA antibody level	J:111811
	increased macrophage cell number	J:111811
	increased neutrophil cell number	J:111811
	increased spleen germinal center number	J:111811
	increased spleen weight	J:111811
	renal glomerular protein deposits	J:111811

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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