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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Camk2a
calcium/calmodulin-dependent protein kinase II alpha
MGI:88256
55 phenotypes from 12 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Camk2aem1Rjco/Camk2a+
involves: C57BL/6J * DBA/2J 		abnormal response to social novelty J:239596
decreased exploration in new environment J:239596
increased thigmotaxis J:239596
Camk2aem1Rjco/Camk2aem1Rjco
involves: C57BL/6J * DBA/2J 		abnormal social/conspecific interaction behavior J:239596
circling J:239596
decreased exploration in new environment J:239596
hyperactivity J:239596
increased thigmotaxis J:239596
increased vertical activity J:239596
Camk2am1Btlr/Camk2am1Btlr
C57BL/6J-Camk2am1Btlr 		hyperactivity J:265120
Camk2atm1.1Oyam/Camk2a+
either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR) 		decreased survivor rate J:150046
hyperactivity J:150046
premature death J:150046
sporadic seizures J:150046
Camk2atm1.1Oyam/Camk2atm1.1Oyam
either: B6.Cg-Camk2atm1.1Oyam or (involves: C57BL/6 * CBA * ICR) 		abnormal avoidance learning behavior J:150046
abnormal neuron morphology J:150046
abnormal short-term spatial reference memory J:150046
abnormal spatial learning J:150046
decreased survivor rate J:150046
hyperactivity J:150046
premature death J:150046
reduced long-term potentiation J:150046
sporadic seizures J:150046
Camk2atm1.1Yelg/Camk2atm1.1Yelg
Emx1tm1.1(cre)Ito/0
B6J.Cg-Camk2atm1.1Yelg Emx1tm1.1(cre)Ito 		impaired contextual conditioning behavior J:216169
impaired spatial learning J:216169
Camk2atm1.1Yelg/Camk2atm1.1Yelg
Tg(CAG-cre/Esr1*)5Amc/0
B6J.Cg-Camk2atm1.1Yelg Tg(CAG-cre/Esr1*)5Amc 		impaired contextual conditioning behavior J:216169
impaired spatial learning J:216169
impaired synaptic plasticity J:216169
reduced long-term potentiation J:216169
Camk2atm1.1Yelg/Camk2atm1.1Yelg
Tg(Pcp2-cre)2Mpin/0
B6J.Cg-Camk2atm1.1Yelg Tg(Pcp2-cre)2Mpin 		normal behavior/neurological phenotype J:216169
Camk2atm1Kub/Camk2atm1Kub
involves: 129 * C57BL/6 		absent long-term depression J:208776
Camk2atm1Mllr/Camk2atm1Mllr
B6.129-Camk2atm1Mllr 		abnormal contextual conditioning behavior J:79713
abnormal cued conditioning behavior J:79713
abnormal spatial learning J:79713
impaired long-term object recognition memory J:79713
Camk2atm1Mllr/Camk2atm1Mllr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal contextual conditioning behavior J:79713
abnormal cued conditioning behavior J:79713
abnormal long-term potentiation J:79713
abnormal spatial learning J:79713
Camk2atm1Sva/Camk2a+
B6.129P2-Camk2atm1Sva/J 		abnormal CNS synaptic transmission J:263327
abnormal dentate gyrus morphology J:263327
abnormal hippocampus granule cell morphology J:263327
abnormal locomotor behavior J:234969, J:263327
abnormal neuron physiology J:263327
abnormal postsynaptic density morphology J:263327
abnormal synapse morphology J:263327
abnormal synaptic vesicle morphology J:263327
decreased anxiety-related response J:263327
decreased body weight J:263327
decreased depression-related behavior J:263327
impaired spatial working memory J:263327
increased aggression towards mice J:263327
increased cell proliferation J:263327
increased locomotor activity J:263327
Camk2atm1Sva/Camk2a+
involves: 129P2/OlaHsd * C57BL/6J 		increased cerebral infarct size J:113259
Camk2atm1Sva/Camk2atm1Sva
involves: 129P2/OlaHsd 		abnormal CNS synaptic transmission J:113007
reduced long-term depression J:113007
reduced long-term potentiation J:113007
Camk2atm1Sva/Camk2atm1Sva
involves: 129P2/OlaHsd * BALB/c 		decreased anxiety-related response J:1421
decreased paired-pulse facilitation J:1421
normal nervous system phenotype J:1421
reduced long-term potentiation J:1421
Camk2atm1Sva/Camk2atm1Sva
involves: 129P2/OlaHsd * C57BL/6J 		increased cerebral infarct size J:113259
Camk2atm1Vyb/Camk2atm1Vyb
Tg(Grik4-cre)G32-4Stl/0
involves: C57BL/6 		abnormal CNS synaptic transmission J:82744
abnormal synaptic transmission J:82744
Camk2atm2Sva/Camk2atm2Sva
B6.129P2-Camk2atm2Sva 		abnormal cutaneous/subcutaneous mechanoreceptor morphology J:116531
abnormal dendrite morphology J:116531
abnormal excitatory postsynaptic currents J:116531
abnormal skin condition J:116531
Camk2atm2Sva/Camk2atm2Sva
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		absent long-term depression J:208776
normal nervous system phenotype J:127397
reduced long-term potentiation J:127397
Camk2atm3Sva/Camk2atm3Sva
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal excitatory postsynaptic potential J:127397
abnormal synaptic plasticity J:127397
abnormal synaptic vesicle morphology J:127397
abnormal synaptic vesicle number J:127397
reduced long-term potentiation J:127397
Camk2atm3Sva/Camk2atm3Sva
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac 		abnormal contextual conditioning behavior J:79714
abnormal spatial learning J:79714
reduced long-term potentiation J:79714
Camk2atm4Sva/Camk2atm4Sva
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		enhanced long-term potentiation J:127397
normal nervous system phenotype J:127397
Camk2atm4Sva/Camk2atm4Sva
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac 		abnormal contextual conditioning behavior J:79714
abnormal long-term potentiation J:79714
abnormal spatial learning J:79714
enhanced coordination J:79714
seizures J:79714
Camk2atm5Sva/Camk2a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac 		normal behavior/neurological phenotype J:79714
reduced long-term potentiation J:79714
Camk2atm5Sva/Camk2atm5Sva
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal nervous system phenotype J:127397
reduced long-term potentiation J:127397
Camk2atm5Sva/Camk2atm5Sva
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac 		abnormal contextual conditioning behavior J:79714
abnormal long-term depression J:79714
abnormal spatial learning J:79714
reduced long-term potentiation J:79714
seizures J:79714
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory