Camk4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Camk4
calcium/calmodulin-dependent protein kinase IV
MGI:88258

67 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Camk4^{em1(IMPC)Ccpcz}/Camk4^{em1(IMPC)Ccpcz} C57BL/6N-Camk4^{em1(IMPC)Ccpcz}/Ccpcz	abnormal heart morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal testis morphology	J:211773
	abnormal thymus morphology	J:211773
	abnormal tooth morphology	J:211773
	enlarged heart	J:211773
	enlarged testis	J:211773
	enlarged thymus	J:211773
	small spleen	J:211773
Camk4^tm1Arm/Camk4^tm1Arm involves: 129 * C57BL/6J	abnormal female reproductive system morphology	J:66075
	abnormal gametogenesis	J:70570
	abnormal male reproductive system morphology	J:70570
	abnormal ovarian follicle morphology	J:66075
	abnormal Purkinje cell morphology	J:70431
	abnormal reproductive system morphology	J:66075, J:70570
	abnormal reproductive system physiology	J:66075
	abnormal sperm flagellum morphology	J:70570
	abnormal sperm head morphology	J:70570
	abnormal spermiogenesis	J:70570
	abnormal synaptic depression	J:70431
	absent corpus luteum	J:66075
	anovulation	J:66075
	arrest of spermatogenesis	J:70570
	ataxia	J:70431
	decreased body weight	J:70570
	decreased excitatory postsynaptic current amplitude	J:70431
	decreased litter size	J:66075
	decreased locomotor activity	J:70431
	decreased male germ cell number	J:70570
	decreased Purkinje cell number	J:70431
	decreased spermatid number	J:70570
	decreased testis weight	J:70570
	decreased vertical activity	J:70431
	normal homeostasis/metabolism phenotype	J:70570
	impaired coordination	J:70431
	increased excitatory postsynaptic current amplitude	J:70431
	limb grasping	J:70431
	male infertility	J:70570
	oligozoospermia	J:70570
	polyovular ovarian follicle	J:66075
	premature death	J:66075
	reduced female fertility	J:66075
	seminiferous tubule degeneration	J:70570
	teratozoospermia	J:70570
	tremors	J:70431
Camk4^tm1Gsc/Camk4^tm1Gsc Tg(Drd1a-cre)1Gsc/0 involves: 129 * FVB/N	enhanced behavioral response to cocaine	J:142518
Camk4^tm1Tch/Camk4^tm1Tch B6.129X1-Camk4^tm1Tch	abnormal bone remodeling	J:129599
	abnormal inhibitory postsynaptic currents	J:108062
	abnormal learning/memory/conditioning	J:122984
	abnormal osteoclast differentiation	J:129599
	decreased chemically-elicited antinociception	J:108062
	decreased osteoclast cell number	J:129599
	impaired conditioned place preference behavior	J:108062
	increased bone mineral density	J:129599
	increased bone volume	J:129599
Camk4^tm1Tch/Camk4^tm1Tch involves: 129X1/SvJ * C57BL/6	abnormal excitatory postsynaptic currents	J:64210
	abnormal locomotor activation	J:64210
	abnormal Purkinje cell dendrite morphology	J:64210
	normal behavior/neurological phenotype	J:64210
	decreased excitatory postsynaptic current frequency	J:64210
	normal nervous system phenotype	J:64210
	reduced long-term depression	J:64210
Camk4^tm1Tsmi/Camk4^tm1Tsmi B6N.129S-Camk4^tm1Tsmi	abnormal behavior	J:158693
	normal behavior/neurological phenotype	J:158693
	decreased anxiety-related response	J:158693
	decreased body weight	J:158693
	impaired contextual conditioning behavior	J:158693
	impaired cued conditioning behavior	J:158693
Camk4^tm2Arm/Camk4^tm2Arm involves: 129 * C57BL/6J	no abnormal phenotype detected	J:70856

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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