About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctnnb1
catenin beta 1
MGI:88276
356 phenotypes from 17 alleles in 65 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		increased granulosa cell tumor incidence J:186144
increased testis tumor incidence J:186144
male infertility J:186144
seminiferous tubule degeneration J:186144
testicular atrophy J:186144
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		abnormal Mullerian duct morphology J:171430
abnormal sex determination J:171430
failure of Mullerian duct regression J:171430
Axin2tm1.1(cre/ERT2/tdTomato)Eem/Axin2+
Ctnnb1tm2Kem/Ctnnb1tm2Kem
involves: 129S2/SvPas * C57BL/6 		decreased cell proliferation J:204142
Bmi1tm1(cre/ERT)Mrc/Bmi1+
Ctnnb1tm1Mmt/Ctnnb1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal crypts of Lieberkuhn morphology J:138364
increased intestinal adenoma incidence J:138364
premature death J:138364
Ctnnb1Bfc/Ctnnb1+
either: (involves: BALB/cCrl * C3H/HeNCrl) or (involves: BALB/cCrl * C3H/HeNCrl * C57BL/6) 		abnormal eye morphology J:170646
abnormal head morphology J:170646
anophthalmia J:170646
cataract J:170646
flattened snout J:170646
forebrain hypoplasia J:170646
microphthalmia J:170646
preweaning lethality, incomplete penetrance J:170646
Ctnnb1Bfc/Ctnnb1+
involves: BALB/cCrl * C3H/HeNCrl 		abnormal globus pallidus morphology J:209611
abnormal hippocampus neuron morphology J:209611
abnormal operant conditioning behavior J:209611
abnormal spatial reference memory J:209611
abnormal synaptic vesicle clustering J:209611
abnormal vocalization J:209611
broad head J:63816, J:209611
decreased corpus callosum size J:209611
decreased prepulse inhibition J:209611
enlarged thalamus J:209611
impaired contextual conditioning behavior J:209611
impaired coordination J:209611
increased brain size J:209611
increased striatum size J:209611
ocular hypertelorism J:63816
reduced long-term potentiation J:209611
small cerebellum J:209611
small olfactory bulb J:209611
Ctnnb1Bfc/Ctnnb1Bfc
either: (involves: BALB/cCrl * C3H/HeNCrl) or (involves: BALB/cCrl * C3H/HeNCrl * C57BL/6) 		abnormal head size J:170646
preweaning lethality, complete penetrance J:170646
Ctnnb1em1V/Ctnnb1em1V
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
involves: C57BL/6 * C57BL/6J * CBA 		abnormal retina development J:328283
decreased angiogenesis J:328283
Ctnnb1tm1.1Smoc/Ctnnb1tm1.1Smoc
Sox9em1(cre/ERT2)Tchn/Sox9+
involves: C57BL/6 		increased incidence of tumors by chemical induction J:322311
Ctnnb1tm1Kba/Ctnnb1tm1Kba
involves: 129S6/SvEvTac * C57BL/6 		abnormal craniofacial development J:178971
abnormal forebrain development J:178971
decreased embryo size J:178971
embryonic growth retardation J:178971
small pharyngeal arch J:178971
Ctnnb1tm1Max/Ctnnb1tm1Max
involves: 129 * 129S1/Sv * 129X1/SvJ 		abnormal embryonic epiblast morphology J:29881
abnormal extraembryonic tissue morphology J:29881
abnormal germ layer development J:29881
absent allantois J:29881
absent amniotic folds J:29881
decreased embryo size J:29881
embryonic lethality during organogenesis, complete penetrance J:29881
Ctnnb1tm1Max/Ctnnb1tm2Kem
Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal apical ectodermal ridge morphology J:81795
abnormal forelimb morphology J:81795
abnormal humerus morphology J:81795
abnormal suckling behavior J:81795
abnormal ulna morphology J:81795
absent deltoid tuberosity J:81795
absent hindlimb J:81795
increased ectoderm apoptosis J:81795
neonatal lethality, complete penetrance J:81795
Ctnnb1tm1Max/Ctnnb1tm2Kem
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal bone mineralization J:114494
abnormal bone ossification J:114494
abnormal cartilage morphology J:114494
abnormal limb development J:114494
arrested osteoblast differentiation J:114494
Ctnnb1tm1Mmt/Ctnnb1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		abnormal small intestinal crypt cell proliferation J:169830
abnormal small intestine morphology J:169830
increased intestinal adenoma incidence J:169830
Ctnnb1tm1Mmt/Ctnnb1+
involves: 129X1/SvJ 		no abnormal phenotype detected J:58367
Ctnnb1tm1Mmt/Ctnnb1+
Krt19tm1(cre)Mmt/Krt19+
involves: 129X1/SvJ 		increased intestinal adenoma incidence J:58367
premature death J:58367
Ctnnb1tm1Mmt/Ctnnb1+
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal osteoclast differentiation J:178340
decreased bone marrow cell number J:178340
decreased bone resorption J:178340
increased bone volume J:178340
normal skeleton phenotype J:178340
Ctnnb1tm1Mmt/Ctnnb1+
Krt14tm1.1(cre)Wbm/Krt14+
involves: 129P2/OlaHsd * 129X1/SvJ 		normal neoplasm J:199091
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Pou3f4-cre)32Cren/?
involves: 129X1/SvJ 		abnormal brain morphology J:83935
abnormal nervous system morphology J:83935
increased brain size J:83935
increased spinal cord size J:83935
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Col2a1-cre)1Bhr/0
involves: 129X1/SvJ 		decreased length of long bones J:90567
lethality throughout fetal growth and development, incomplete penetrance J:90567
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal trabecular bone morphology J:112659
increased hepatoblastoma incidence J:112659
premature death J:112659
skin fibrosis J:112659
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Wap-cre)11738Mam/0
FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam 		increased mammary gland tumor incidence in breeding females J:206839
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Pbsn-cre)4Prb/0
involves: 129X1/SvJ * C57BL/6 * DBA/2 		increased prostate gland adenocarcinoma incidence J:143034, J:284956
increased prostate intraepithelial neoplasia incidence J:143034, J:284956
premature death J:143034
squamous metaplasia of bulbourethral gland J:143034
squamous metaplasia of preputial gland J:143034
squamous metaplasia of urethral gland J:143034
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Tek-cre)1Ywa/0
involves: 129X1/SvJ * C57BL/6 * SJL 		embryonic lethality, complete penetrance J:178340
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Cdh16-cre)91Igr/0
involves: 129X1/SvJ * ICR 		dilated renal tubule J:151498
kidney cyst J:151498
postnatal lethality, complete penetrance J:151498
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Fabp1-cre)1Mmt/?
involves: 129X1/SvJ 		increased intestinal adenoma incidence J:58367
premature death J:58367
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Hoxb7-cre)13Amc/0
involves: 129X1/SvJ * C57BL/6 		abnormal kidney development J:160547
absent kidney J:160547
single kidney J:160547
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Col1a1-cre)1Kry/0
involves: 129X1/SvJ * FVB 		absent lower incisors J:98430
decreased osteoclast cell number J:98430
increased bone mass J:98430
increased osteoma incidence J:98430
lethality at weaning, complete penetrance J:98430
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Upk2-cre)6Xrw/0
involves: 129X1/SvJ * FVB/N 		abnormal urinary bladder urothelium morphology J:164579, J:174242
normal neoplasm J:164579, J:174242
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129X1/SvJ * CD-1 		abnormal bone ossification J:114494
abnormal long bone epiphyseal plate morphology J:114494
abnormal osteoblast differentiation J:114494
abnormal osteoclast differentiation J:114494
abnormal trabecular bone morphology J:114494
delayed intramembranous bone ossification J:114494
perinatal lethality, complete penetrance J:114494
premature endochondral bone ossification J:114494
short limbs J:114494
Ctnnb1tm1Mmt/Ctnnb1+
Ctsktm1(cre)Ska/Ctsk+
involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal osteoclast differentiation J:178340
decreased bone marrow cell number J:178340
decreased bone resorption J:178340
increased bone volume J:178340
normal skeleton phenotype J:178340
Ctnnb1tm1Mmt/Ctnnb1+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129X1/SvJ 		intestine polyps J:193873
Ctnnb1tm1Mmt/Ctnnb1+
Nanos3tm2(cre)Ysa/Nanos3+
involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal seminiferous tubule morphology J:257319
abnormal spermatogonia morphology J:257319
Ctnnb1tm1Mmt/Ctnnb1+
Tg(CYP19A1-cre)1Jri/0
involves: 129X1/SvJ * C57BL/6 		increased granulosa cell tumor incidence J:186144
increased ovary tumor incidence J:186144
premature death J:186144
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Tcfap2a-cre)1Will/0
involves: 129X1/SvJ * C57BL/6 		abnormal cartilage development J:168016
abnormal eye morphology J:168016
abnormal face development J:168016
abnormal facial morphology J:168016
abnormal mandibular prominence morphology J:168016
abnormal maxillary prominence morphology J:168016
abnormal Meckel's cartilage morphology J:168016
abnormal medial nasal prominence morphology J:168016
abnormal oral cavity morphology J:168016
absent outer ear J:168016
absent vibrissae J:168016
ectopic cartilage J:168016
embryonic lethality during organogenesis, incomplete penetrance J:168016
lethality throughout fetal growth and development, incomplete penetrance J:168016
Ctnnb1tm1Mmt/Ctnnb1+
Dclk1tm1.1(cre/ERT2)Seno/Dclk1+
involves: 129X1/SvJ * C57BL/6 		normal neoplasm J:193873
Ctnnb1tm1Mmt/Ctnnb1+
Sox2tm1.1(cre/ERT2)Jpmb/Sox2+
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 		abnormal adenohypophysis morphology J:201265
increased pituitary gland tumor incidence J:201265
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Msx2-rtTA)885Lma/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129X1/SvJ * C57BL/6 		abnormal craniofacial morphology J:202618
abnormal urinary bladder morphology J:202618
alopecia J:202618
increased urinary bladder carcinoma incidence J:202618
premature death J:202618
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
involves: 129X1/SvJ 		no abnormal phenotype detected J:58367
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Gli1tm3(cre/ERT2)Alj/Gli1+
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal external female genitalia morphology J:148515
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal muscle development J:124278
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Nanos3tm2(cre)Ysa/Nanos3+
involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal seminiferous tubule morphology J:257319
abnormal spermatogonia morphology J:257319
decreased testis weight J:257319
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Osr2tm5(cre)Jian/Osr2+
involves: 129X1/SvJ 		abnormal dental mesenchyme morphology J:153554
abnormal tooth development J:153554
cleft palate J:153554
neonatal lethality J:153554
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129X1/SvJ 		abnormal lung development J:204743
abnormal lung vasculature morphology J:204743
abnormal pulmonary artery morphology J:204743
abnormal pulmonary vein morphology J:204743
absent lungs J:204743
normal cardiovascular system phenotype J:204743
tracheoesophageal fistula J:153098
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tcf21tm1(cre)Seq/Tcf21+
involves: 129S1/Sv * 129X1/SvJ 		abnormal kidney development J:189643
hydroureter J:189643
kidney cyst J:189643
neonatal lethality J:189643
renal hypoplasia J:189643
ureter hypoplasia J:189643
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Cryaa-cre)10Mlr/0
involves: 129X1/SvJ * FVB/N 		abnormal lens epithelium morphology J:152850
increased lens epithelium apoptosis J:152850
microphthalmia J:152850
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		ectopic limbs J:223057
polydactyly J:223057
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal trabecular bone morphology J:112659
increased hepatoblastoma incidence J:112659
premature death J:112659
skin fibrosis J:112659
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Pitx1-cre)7Rsd/0
involves: 129X1/SvJ * BALB/c * C57BL/6 		absent pituitary gland J:114817
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Upk2-cre)6Xrw/0
involves: 129X1/SvJ * FVB/N 		abnormal urinary bladder urothelium morphology J:164579, J:234236
normal neoplasm J:164579
Ctnnb1tm1Wbm/Ctnnb1tm1Wbm
involves: 129P2/OlaHsd * C57BL/6 		abnormal developmental patterning J:60391
abnormal ectoderm development J:60391
abnormal gastrulation J:60391
abnormal germ layer development J:60391
abnormal mesoderm development J:60391
abnormal proximal-distal axis patterning J:60391
abnormal rostral-caudal axis patterning J:60391
absent mesoderm J:60391
decreased embryo size J:60391
embryonic lethality during organogenesis, complete penetrance J:60391
failure to gastrulate J:60391
Ctnnb1tm1Yy/Ctnnb1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal perichondrium morphology J:112462
decreased bone mineralization J:112462
failure of bone ossification J:112462
increased chondrocyte apoptosis J:112462
Ctnnb1tm1Yy/Ctnnb1tm1Yy
Tg(Col2a1-cre)1Bhr/0
involves: 129S6/SvEvTac * C57BL/6 		domed cranium J:93028
fused synovial joints J:93028
neonatal lethality, complete penetrance J:93028
short limbs J:93028
Ctnnb1tm1Yy/Ctnnb1tm1Yy
Tg(Prnp-GFP/cre)1Blw/0
involves: 129S6/SvEvTac * C57BL/6 		domed cranium J:93028
fused synovial joints J:93028
neonatal lethality, complete penetrance J:93028
short limbs J:93028
Ctnnb1tm1Yy/Ctnnb1tm1Yy
Tg(Prrx1-cre)1Cjt/0
involves: 129S6/SvEvTac * C57BL/6J * SJL/J 		abnormal hair follicle development J:184918
abnormal ligament morphology J:184918
abnormal limb development J:184918
abnormal melanogenesis J:184918
abnormal tendon morphology J:184918
Ctnnb1tm1Yy/Ctnnb1tm1Yy
Twist2tm1(cre)Dor/Twist2+
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		fused synovial joints J:93028
Ctnnb1tm2.1Kem/Ctnnb1tm2.1Kem
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 		abnormal inner cell mass morphology J:67966
absent mesoderm J:178971
embryonic lethality between implantation and somite formation, complete penetrance J:178971
embryonic lethality, complete penetrance J:67966
Ctnnb1tm2Kem/Ctnnb1+
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
Ctnnb1tm2Kem/Ctnnb1+
Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
Ctnnb1tm2Kem/Ctnnb1+
Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6 * SJL 		abnormal skeleton morphology J:173242
Ctnnb1tm2Kem/Ctnnb1+
Ctsktm1(cre)Ska/Ctsk+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
Ctnnb1tm2Kem/Ctnnb1+
Osr2tm2(cre)Jian/Osr2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal enamel knot morphology J:153554
cleft secondary palate J:153554
growth retardation of incisors J:153554
growth retardation of molars J:153554
neonatal lethality J:153554
Ctnnb1tm2Kem/Ctnnb1+
Nanos3tm2(cre)Ysa/Nanos3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal seminiferous tubule morphology J:257319
abnormal spermatogonia morphology J:257319
decreased testis weight J:257319
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA 		abnormal embryonic tissue morphology J:187739
prenatal lethality, complete penetrance J:187739
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129/Sv * C57BL/6 * CBA 		abnormal brain development J:67966
abnormal brain morphology J:67966
abnormal cranial nerve morphology J:67966
abnormal dorsal root ganglion morphology J:67966
abnormal facial nerve morphology J:67966
abnormal glossopharyngeal nerve morphology J:67966
abnormal hindbrain morphology J:67966
abnormal hypoglossal nerve morphology J:67966
abnormal neural tube morphology J:67966
abnormal telencephalon morphology J:67966
abnormal trigeminal V mesencephalic nucleus morphology J:67966
abnormal vagus nerve morphology J:67966
absent cerebellum J:67966
absent choroid plexus J:67966
absent craniofacial bones J:67966
absent metencephalon J:67966
absent midbrain J:67966
absent midbrain-hindbrain boundary J:67966
absent oculomotor nerve J:67966
prenatal lethality, complete penetrance J:67966
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Kdrtm1(cre)Sato/Kdr+
involves: 129S1/Sv * 129X1/SvJ 		abnormal blood-brain barrier function J:142352
abnormal vasculogenesis J:142352
embryonic lethality during organogenesis, complete penetrance J:142352
intracranial hemorrhage J:142352
spinal hemorrhage J:142352
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(Foxn1-cre)1Tbo/0
involves: 129S1/Sv * 129X1/SvJ 		neonatal lethality, complete penetrance J:187739
skin lesions J:187739
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(T-cre)1Lwd/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 		abnormal somite development J:200549
caudal body truncation J:200549
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(T-cre/ERT2)1Lwd/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeNcr * C57BL/6NCr 		abnormal axial mesoderm morphology J:200549
abnormal somite development J:200549
caudal body truncation J:200549
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal blood vessel morphology J:85505
abnormal endocardium morphology J:85505
abnormal placenta morphology J:85505
abnormal placental labyrinth vasculature morphology J:85505
abnormal umbilical cord blood vessel morphology J:85505
abnormal vascular endothelial cell morphology J:85505
abnormal visceral yolk sac morphology J:85505
abnormal vitelline vasculature morphology J:85505
embryonic lethality during organogenesis, complete penetrance J:85505
hemorrhage J:85505
pale yolk sac J:85505
pericardial edema J:85505
small heart J:85505
thin placenta labyrinth J:85505
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(Zp3-cre)93Knw/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J 		abnormal embryonic tissue morphology J:187739
prenatal lethality, complete penetrance J:187739
Ctnnb1tm2Kem/Ctnnb1tm2Kem
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		decreased response of heart to induced stress J:109612
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ctsktm1(cre)Ska/Ctsk+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Emx1tm1(cre)Yql/Emx1+
B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem 		abnormal cerebral cortex morphology J:92923
abnormal hippocampus morphology J:92923
abnormal nursing J:92923
absent corpus callosum J:92923
absent dentate gyrus J:92923
absent hippocampal commissure J:92923
absent hippocampus CA1 region J:92923
absent hippocampus CA2 region J:92923
absent hippocampus CA3 region J:92923
decreased body size J:92923
dilated lateral ventricle J:92923
increased susceptibility to pharmacologically induced seizures J:92923
male infertility J:92923
seizures J:92923
Ctnnb1tm2Kem/Ctnnb1tm2Kem
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129 * C57BL/6 * CBA/J 		abnormal craniofacial morphology J:178971
abnormal neural tube morphology J:178971
abnormal telencephalon development J:178971
absent midbrain-hindbrain boundary J:178971
premature neuronal precursor differentiation J:178971
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Nanos3tm2(cre)Ysa/Nanos3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal seminiferous tubule morphology J:257319
abnormal spermatogonia morphology J:257319
decreased testis weight J:257319
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Olig2tm1(cre)Tmj/Olig2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal spinal cord medial motor column morphology J:178688
decreased motor neuron number J:178688
neonatal lethality, complete penetrance J:178688
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Osr2tm2(cre)Jian/Osr2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal joint morphology J:171478
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Pvalbtm1(cre)Arbr/Pvalb+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal head movements J:236989
abnormal nest building behavior J:236989
abnormal neuron physiology J:236989
abnormal response to social novelty J:236989
normal behavior/neurological phenotype J:236989
enhanced spatial learning J:236989
impaired long-term object recognition memory J:236989
increased anxiety-related response J:236989
increased grooming behavior J:236989
increased thigmotaxis J:236989
slow extinction of fear memory J:236989
stereotypic behavior J:236989
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal lung development J:153098
absent lung buds J:153098
absent lungs J:153098
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tcf21tm1(cre)Seq/Tcf21+
involves: 129S1/Sv * 129X1/SvJ 		abnormal kidney development J:189643
fused kidneys J:189643
increased tumor incidence J:189643
prenatal lethality J:189643
renal hypoplasia J:189643
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Col1a1-cre)1Kry/0
involves: 129S1/Sv * 129X1/SvJ * FVB 		decreased bone mass J:98430
increased osteoclast cell number J:98430
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Col2a1-cre)1Bhr/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal cartilage morphology J:90567
abnormal chondrocyte morphology J:90567
abnormal craniofacial bone morphology J:90567
decreased length of long bones J:90567
domed cranium J:90567
short limbs J:90567
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Col2a1-cre)3Amc/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal long bone morphology J:114494
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Cyp1a1-cre)1Dwi/0
involves: C57BL/6 * CBA 		abnormal crypts of Lieberkuhn morphology J:92092
abnormal intestinal epithelium morphology J:92092
decreased Paneth cell number J:92092
ectopic Paneth cells J:92092
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Dct-lacZ)A12Jkn/0
Tg(Tyr-cre)1Lru/0
B6.Cg-Ctnnb1tm2Kem Tg(Tyr-cre)1Lru Tg(Dct-lacZ)A12Jkn 		abnormal melanoblast morphology J:176245
decreased melanoblast proliferation J:176245
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Hoxb7-cre)5526Cmb/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal kidney morphology J:136068
absent kidney J:136068
absent nephrogenic zone J:136068
decreased kidney cell proliferation J:136068
decreased kidney collecting duct number J:136068
decreased nephron number J:136068
hydroureter J:136068
impaired branching involved in ureteric bud morphogenesis J:136068
increased metanephric mesenchyme apoptosis J:136068
neonatal lethality, complete penetrance J:136068
small kidney J:136068
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Krt1-15-cre/PGR*)22Cot/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal hair cycle anagen phase J:204142
abnormal hair follicle morphology J:204142
abnormal hair growth J:204142
normal integument phenotype J:204142
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(KRT5-rtTA)#Glk/0
Tg(tetO-cre)1Jaw/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal dermis papillary layer morphology J:204142
abnormal epidermal layer morphology J:204142
abnormal hair cycle anagen phase J:204142
abnormal hair follicle infundibulum morphology J:204142
abnormal hair follicle morphology J:204142
abnormal hair growth J:204142
abnormal keratinocyte morphology J:204142
accelerated hair follicle regression J:204142
decreased hair follicle number J:204142
hair follicle degeneration J:204142
increased hair follicle apoptosis J:204142
thick epidermis J:204142
thick epidermis stratum basale J:204142
thick epidermis suprabasal layer J:204142
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(KRT14-cre)#Smr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J 		abnormal filiform papillae morphology J:242196
abnormal tongue morphology J:242196
decreased cell proliferation J:242196
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(KRT14-cre/ERT)20Efu/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal epidermal layer morphology J:204142
cutaneous mastocytosis J:204142
normal integument phenotype J:204142
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal autopod morphology J:223057
absent deltoid tuberosity J:223057
absent hindlimb J:223057
absent radius J:223057
decreased diameter of humerus J:223057
short ulna J:223057
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA 		abnormal retina vasculature morphology J:144980
abnormal vascular regression J:144980
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Pitx1-cre)7Rsd/0
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 		abnormal adenohypophysis morphology J:114817
absent lactotrophs J:114817
absent somatotrophs J:114817
absent thyrotrophs J:114817
decreased gonadotroph cell number J:114817
increased corticotroph cell number J:114817
small adenohypophysis J:114817
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Tcfap2a-cre)1Will/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal face development J:168016
abnormal facial morphology J:168016
abnormal lateral nasal prominence morphology J:168016
abnormal lens development J:168016
abnormal mandibular prominence morphology J:168016
abnormal maxillary shelf morphology J:168016
abnormal maxillary zygomatic process morphology J:168016
abnormal medial nasal prominence morphology J:168016
abnormal nasal placode morphology J:168016
abnormal neurocranium morphology J:168016
abnormal optic eminence morphology J:168016
abnormal tympanic ring morphology J:168016
absent eyelids J:168016
absent hyoid bone J:168016
absent mandible J:168016
absent middle ear ossicles J:168016
fusion of basioccipital and basisphenoid bone J:168016
narrow frontonasal prominence J:168016
neonatal lethality, complete penetrance J:168016
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		decreased bone resorption J:178340
decreased osteoclast cell number J:178340
increased bone volume J:178340
osteopetrosis J:178340
prenatal lethality, incomplete penetrance J:178340
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Tyr-cre)1Lru/0
B6.Cg-Ctnnb1tm2Kem Tg(Tyr-cre)1Lru 		abnormal hair follicle melanogenesis J:176245
abnormal pinna hair pigmentation J:176245
abnormal tail hair pigmentation J:176245
absent coat pigmentation J:176245
reduced hair shaft melanin granule number J:176245
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone structure J:178499
abnormal cartilage morphology J:178499
abnormal joint morphology J:178499
abnormal skeleton morphology J:178499
arrested osteoblast differentiation J:178499
ectopic cartilage J:178499
failure of bone ossification J:178499
split sternum J:178499
Ctnnb1tm2Kem/Ctnnb1tm3Kba
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129 * C57BL/6 * CBA/J 		abnormal craniofacial morphology J:178971
abnormal midbrain morphology J:178971
abnormal neuron differentiation J:178971
normal embryo phenotype J:178971
Ctnnb1tm2Wbm/Ctnnb1tm2Wbm
involves: 129P2/OlaHsd * C57BL/6 		abnormal developmental patterning J:60391
abnormal ectoderm development J:60391
abnormal gastrulation J:60391
abnormal germ layer development J:60391
abnormal mesoderm development J:60391
abnormal proximal-distal axis patterning J:60391
abnormal rostral-caudal axis patterning J:60391
absent mesoderm J:60391
decreased embryo size J:60391
embryonic lethality during organogenesis, complete penetrance J:60391
failure to gastrulate J:60391
Ctnnb1tm3Kba/Ctnnb1tm3Kba
involves: 129S6/SvEvTac * C57BL/6 		abnormal gastrulation J:178971
absent mesoderm J:178971
embryonic lethality between implantation and somite formation, complete penetrance J:178971
Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
involves: 129P2/OlaHsd * C57BL/6 		abnormal developmental patterning J:60391
abnormal ectoderm development J:60391
abnormal gastrulation J:60391
abnormal germ layer development J:60391
abnormal mesoderm development J:60391
abnormal proximal-distal axis patterning J:60391
abnormal rostral-caudal axis patterning J:60391
absent mesoderm J:60391
decreased embryo size J:60391
embryonic lethality during organogenesis, complete penetrance J:60391
failure to gastrulate J:60391
Ctnnb1tm4Wbm/Ctnnb1+
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd 		absent hair follicles J:186934
alopecia J:186934
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Gli1tm3(cre/ERT2)Alj/Gli1+
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal external male genitalia morphology J:148515
abnormal foreskin morphology J:148515
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Krt14tm1(cre)Wbm/Krt14+
involves: 129P2/OlaHsd 		decreased gamma-delta T cell number J:202499
increased neutrophil cell number J:202499
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Krt14tm1(cre)Wbm/Krt14+
involves: 129P2/OlaHsd * C57BL/6 		abnormal hair growth J:69463
alopecia J:69463
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Krt14tm1.1(cre)Wbm/Krt14+
involves: 129P2/OlaHsd * C57BL/6 		abnormal hair growth J:69463
alopecia J:69463
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Pax3tm1(cre)Joe/Pax3+
Not Specified 		abnormal neural tube morphology J:96431
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Cryaa-cre)10Mlr/?
involves: 129P2/OlaHsd * FVB/N 		abnormal lens capsule morphology J:139969
abnormal lens epithelium morphology J:139969
disorganized secondary lens fibers J:139969
focal hair loss J:139969
loss of vibrissae J:139969
microphthalmia J:139969
ruptured lens capsule J:139969
small lens J:139969
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Cryaa-cre,Tyr)39Mlr/?
involves: 129P2/OlaHsd * FVB/N 		nuclear cataract J:139969
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd 		absent hair follicles J:155012
neonatal lethality, complete penetrance J:155012
thick epidermis J:155012
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Pdx1-cre)6Tuv/0
involves: 129P2/OlaHsd * FVB/N 		abnormal exocrine pancreas morphology J:119908
abnormal pancreas morphology J:119908
abnormal pancreas physiology J:119908
decreased body size J:119908
decreased pancreas weight J:119908
pancreas fibrosis J:119908
pancreas inflammation J:119908
pancreatic acinar hypoplasia J:119908
premature death J:119908
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Pou3f4-cre)32Cren/?
involves: 129P2/OlaHsd * C57BL/6 		abnormal brain morphology J:83935
abnormal nervous system morphology J:83935
decreased brain size J:83935
decreased spinal cord size J:83935
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Prrx1-cre)98Mlgn/0
involves: 129P2/OlaHsd 		abnormal forelimb morphology J:157917
abnormal hindlimb morphology J:157917
abnormal limb development J:157917
Gt(ROSA)26Sortm6(tetO-dTomato,-Ctnnb1*)Bgh/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * C57BL/6 		abnormal cell physiology J:187862
Tg(Dct-lacZ)A12Jkn/0
Tg(Tyr-Ctnnb1/EGFP)#Lru/0
B6.Cg-Tg(Tyr-Ctnnb1/EGFP)#Lru Tg(Dct-lacZ)A12Jkn 		abnormal melanoblast morphology J:176245
decreased melanoblast proliferation J:176245
Tg(Tyr-Ctnnb1/EGFP)#Lru/0
B6.Cg-Tg(Tyr-Ctnnb1/EGFP)#Lru 		abnormal hair follicle melanogenesis J:176245
abnormal pinna hair pigmentation J:176245
abnormal tail hair pigmentation J:176245
diluted coat color J:176245
reduced hair shaft melanin granule number J:176245
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory