Cbl Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cbl
Casitas B-lineage lymphoma
MGI:88279

49 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cbl^{tm1b(EUCOMM)Hmgu}/Cbl⁺ C57BL/6N-Cbl^{tm1b(EUCOMM)Hmgu}/Orl	prolonged PR interval	J:211773
	thick ventricular wall	J:211773
Cbl^{tm1b(EUCOMM)Hmgu}/Cbl^{tm1b(EUCOMM)Hmgu} C57BL/6N-Cbl^{tm1b(EUCOMM)Hmgu}/Orl	preweaning lethality, incomplete penetrance	J:211773
Cbl^tm1Ddlb/Cbl⁺ involves: 129S1/Sv * C57BL/6	decreased white adipose tissue amount	J:94416
	improved glucose tolerance	J:121012
	increased body weight	J:121012
	increased susceptibility to diet-induced obesity	J:121012
Cbl^tm1Ddlb/Cbl^tm1Ddlb involves: 129S1/Sv	abnormal myeloblast morphology/development	J:81965
	abnormal T cell physiology	J:81965
	enlarged spleen	J:81965
	increased spleen red pulp amount	J:81965
	spleen hyperplasia	J:81965
Cbl^tm1Ddlb/Cbl^tm1Ddlb involves: 129S1/Sv * C57BL/6	abnormal fat cell morphology	J:94416
	abnormal gas homeostasis	J:94416
	abnormal glucose homeostasis	J:94416
	abnormal lipid homeostasis	J:94416
	abnormal muscle physiology	J:94416
	decreased circulating free fatty acids level	J:94416
	decreased circulating insulin level	J:94416
	decreased circulating leptin level	J:94416
	decreased liver triglyceride level	J:94416
	decreased respiratory quotient	J:94416
	decreased total body fat amount	J:94416
	enlarged spleen	J:103366
	improved glucose tolerance	J:94416
	increased body temperature	J:94416
	increased insulin sensitivity	J:94416
	increased lean body mass	J:94416
	increased locomotor activity	J:94416
	increased mitochondrial size	J:94416
	increased oxygen consumption	J:94416
	increased skeletal muscle cell glucose uptake	J:94416
	increased spleen red pulp amount	J:103366
	polyphagia	J:94416
	spleen hyperplasia	J:103366
Cbl^tm1Ddlb/Cbl^tm1Ddlb involves: 129S1/Sv * C57BL/6J	abnormal bone marrow cell morphology/development	J:76895
	abnormal branching of the mammary ductal tree	J:76895
	abnormal lymph node cell ratio	J:76895
	abnormal mammary fat pad morphology	J:76895
	abnormal spleen morphology	J:76895
	abnormal splenic cell ratio	J:76895
	abnormal thymus cell ratio	J:76895
	enlarged lymph nodes	J:76895
	enlarged spleen	J:76895
	extramedullary hematopoiesis	J:76895
	normal skeleton phenotype	J:76895
	thrombocytosis	J:76895
Cbl^tm1Dejs/Cbl^tm1Dejs involves: 129S1/Sv * C57BL/6	normal growth/size/body region phenotype	J:121012
Cbl^tm1Dejs/Cbl^tm1Dejs involves: 129S1/Sv * C57BL/6	normal homeostasis/metabolism phenotype	J:121012
Cbl^tm1Soga/Cbl^tm1Soga Not Specified	enlarged spleen	J:151543
Cbl^tm1Soga/Cbl^tm1Soga Not Specified	increased hematopoietic stem cell number	J:151543
Cbl^tm1Wlan/Cbl^tm1Wlan involves: 129S1/Sv * C57BL/6	abnormal myeloblast morphology/development	J:81965
	abnormal T cell physiology	J:81965
	dilated oviduct	J:81965
	dilated uterus	J:81965
	enlarged spleen	J:81965
	increased spleen red pulp amount	J:81965
	myeloid hyperplasia	J:81965
	postnatal lethality	J:81965
	spleen hyperplasia	J:81965

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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