Cacna1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cacna1b
calcium channel, voltage-dependent, N type, alpha 1B subunit
MGI:88296

62 phenotypes from 6 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cacna1b^tm1.1Dili/Cacna1b^tm1.1Dili involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal single cell response	J:165258
	normal behavior/neurological phenotype	J:165258
	postnatal lethality, incomplete penetrance	J:165258
Cacna1b^{tm1b(KOMP)Wtsi}/Cacna1b^{tm1b(KOMP)Wtsi} C57BL/6N-Cacna1b^{tm1b(KOMP)Wtsi}/H	abnormal behavior	J:211773
	abnormal gait	J:211773
	abnormal locomotor behavior	J:211773
	decreased anxiety-related response	J:211773
	decreased fasting circulating glucose level	J:211773
	decreased grip strength	J:211773
	decreased thigmotaxis	J:211773
	hyperactivity	J:211773
	increased exploration in new environment	J:211773
Cacna1b^tm1Hssh/Cacna1b^tm1Hssh involves: 129S4/SvJae * C57BL/6J	abnormal channel response	J:71480
	abnormal conditioned taste aversion behavior	J:96593
	abnormal discrimination learning	J:137285
	abnormal excitatory postsynaptic potential	J:137285
	abnormal hypothalamus secretion	J:147238
	abnormal inhibitory postsynaptic currents	J:147238
	abnormal learning/memory/conditioning	J:137285
	abnormal long-term spatial reference memory	J:137285
	abnormal miniature excitatory postsynaptic currents	J:137285
	abnormal miniature inhibitory postsynaptic currents	J:147238
	abnormal nervous system electrophysiology	J:147238
	abnormal sensory capabilities/reflexes/nociception	J:71480
	abnormal single cell response	J:147238
	abnormal spatial learning	J:137285
	abnormal summary potential	J:147238
	abnormal synaptic transmission	J:147238
	alcohol aversion	J:96593
	normal behavior/neurological phenotype	J:71480
	decreased alcohol consumption	J:96593
	enhanced behavioral response to alcohol	J:96593
	normal homeostasis/metabolism phenotype	J:96593
	hyporesponsive to tactile stimuli	J:71480
	impaired behavioral response to alcohol	J:96593
	impaired conditioned place preference behavior	J:96593
	impaired social transmission of food preference	J:137285
	increased aggression towards mice	J:147238
	increased chemical nociceptive threshold	J:71480
	increased thermal nociceptive threshold	J:71480
	normal nervous system phenotype	J:71480
	reduced long-term potentiation	J:137285
Cacna1b^tm1Ksw/Cacna1b^tm1Ksw involves: C57BL/6 * CBA	abnormal baroreceptor physiology	J:76458
	abnormal channel response	J:103705
	abnormal frequency of paradoxical sleep	J:84684
	abnormal lipid level	J:105212
	abnormal sleep duration	J:84684
	abnormal sleep pattern	J:84684
	abnormal sympathetic nervous system physiology	J:76458
	normal behavior/neurological phenotype	J:103705
	decreased circulating glucagon level	J:105212
	decreased circulating insulin level	J:105212
	decreased circulating leptin level	J:105212
	decreased circulating triglyceride level	J:105212
	decreased susceptibility to diet-induced obesity	J:105212
	normal endocrine/exocrine gland phenotype	J:105212
	fragmentation of sleep/wake states	J:84684
	normal growth/size/body region phenotype	J:103705
	normal homeostasis/metabolism phenotype	J:84684, J:105212
	hyperactivity	J:84684
	hypertension	J:76458
	improved glucose tolerance	J:105212
	increased chemical nociceptive threshold	J:103705
	increased heart rate	J:76458
	increased thermal nociceptive threshold	J:103705
Cacna1b^tm1Ttan/Cacna1b^tm1Ttan involves: 129S4/SvJae * C57BL/6	abnormal behavioral response to xenobiotic	J:107971
	abnormal excitatory postsynaptic potential	J:107971
	decreased anxiety-related response	J:69585
	decreased startle reflex	J:69585
	hyporesponsive to tactile stimuli	J:69585
	increased chemical nociceptive threshold	J:69585
	normal nervous system phenotype	J:69585
	preweaning lethality, incomplete penetrance	J:69585
Cacna1b^tm2.1Dili/Cacna1b^tm2.1Dili involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal single cell response	J:165258
	decreased chemically-elicited antinociception	J:165258
Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan/0 C57BL/6J-Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan	normal behavior/neurological phenotype	J:221994
	decreased susceptibility to injury	J:221994

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