Ccne1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ccne1
cyclin E1
MGI:88316

38 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ccne1^tm1Jro/? Cdkn1a^tm1Led/Cdkn1a^tm1Led either: (involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J) or (involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6J)	abnormal cell morphology	J:99695
	chromosome breakage	J:99695
	decreased fibroblast proliferation	J:99695
Ccne1^tm1Jro/? Kras^tm3Tyj/? either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	chromosome breakage	J:99695
	premature death	J:99695
Ccne1^tm1Jro/? Trp53^tm1Tyj/Trp53^tm1Tyj either: (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J) or (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J)	decreased tumor latency	J:99695
	increased fibroblast proliferation	J:99695
Ccne1^tm1Pisc/Ccne1⁺ Ccne2^tm1Pisc/Ccne2^tm1Pisc involves: 129S2/SvPas	abnormal fertility/fecundity	J:85224
	abnormal reproductive system morphology	J:85224
	reduced male fertility	J:85224
	testis hypoplasia	J:85224
Ccne1^tm1Pisc/Ccne1^tm1Pisc Ccne2^tm1Boa/Ccne2^tm1Boa involves: 129/Sv * C57BL/6	abnormal embryonic growth/weight/body size	J:85497
	abnormal extraembryonic tissue morphology	J:85497
	abnormal trophoblast layer morphology	J:85497
	abnormal vasculogenesis	J:85497
	abnormal vitelline vasculature morphology	J:85497
	embryonic growth retardation	J:85497
	embryonic lethality during organogenesis, incomplete penetrance	J:85497
Ccne1^tm1Pisc/Ccne1^tm1Pisc Ccne2^tm1Pisc/Ccne2⁺ involves: 129S2/SvPas	no abnormal phenotype detected	J:85224
Ccne1^tm1Pisc/Ccne1^tm1Pisc Ccne2^tm1Pisc/Ccne2^tm1Pisc involves: 129S2/SvPas	abnormal aortic arch development	J:85224
	abnormal cardiovascular system morphology	J:85224
	abnormal definitive hematopoiesis	J:85224
	abnormal extraembryonic tissue morphology	J:85224
	abnormal placenta morphology	J:85224
	abnormal thrombopoiesis	J:85224
	abnormal trophoblast giant cell morphology	J:85224
	atrioventricular septal defect	J:85224
	decreased embryo size	J:85224
	double outlet right ventricle	J:85224
	embryonic lethality during organogenesis, complete penetrance	J:85224
	ostium primum atrial septal defect	J:85224
	ventricular septal defect	J:85224
Ccne1^tm2.1Pisc/Ccne1^tm2.1Pisc Ccne2^tm1Pisc/Ccne2^tm1Pisc involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	no abnormal phenotype detected	J:178882
Ccne1^tm3.1Pisc/Ccne1^tm3.1Pisc Ccne2^tm1Pisc/Ccne2^tm1Pisc involves: 129S2/SvPas	abnormal dendritic spine morphology	J:178882
Ccne1^tm3.1Pisc/Ccne1^tm3.1Pisc Ccne2^tm1Pisc/Ccne2^tm1Pisc Tg(Nes-cre)1Kln/0 involves: 129S2/SvPas * C57BL/6 * SJL	abnormal dendritic spine morphology	J:178882
	abnormal excitatory postsynaptic potential	J:178882
	abnormal postsynaptic density morphology	J:178882
	abnormal spatial learning	J:178882
	decreased excitatory postsynaptic current frequency	J:178882
	normal nervous system phenotype	J:178882
	reduced long-term potentiation	J:178882
	reduced NMDA-mediated synaptic currents	J:178882

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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