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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cd19
CD19 antigen
MGI:88319
37 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19em2(IMPC)Ics/Cd19em2(IMPC)Ics
C57BL/6N-Cd19em2(IMPC)Ics/Ics 		decreased lymphocyte cell number J:211773
increased monocyte cell number J:211773
Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:27463
abnormal B cell physiology J:27463
abnormal immunoglobulin level J:27463
absent spleen germinal center J:27463, J:83213
decreased B-1 B cell number J:27463, J:83213
decreased IgE level J:27463
decreased IgG1 level J:27463
decreased IgM level J:27463
Cd19tm1.1Oao/Cd19+
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:202574
Cd19tm1Tft/Cd19tm1Tft
B6.Cg-Cd19tm1Tft 		abnormal B cell physiology J:136210
decreased anti-double stranded DNA antibody level J:136210
decreased anti-nuclear antigen antibody level J:136210
decreased circulating interferon-gamma level J:136210
decreased circulating interleukin-4 level J:136210
decreased circulating interleukin-6 level J:136210
decreased circulating interleukin-10 level J:136210
decreased circulating tumor necrosis factor level J:136210
decreased IgA level J:136210
decreased IgG1 level J:136210
decreased IgG2a level J:136210
decreased IgG2b level J:136210
decreased IgG3 level J:136210
decreased IgM level J:136210
decreased interleukin-10 secretion J:106487
decreased physiological sensitivity to xenobiotic J:136210
demyelination J:106487
increased CD8-positive, alpha-beta T cell number J:106487
increased interferon-gamma secretion J:106487
increased susceptibility to experimental autoimmune encephalomyelitis J:106487
skin fibrosis J:136210
thick dermal layer J:136210
Cd19tm1Tft/Cd19tm1Tft
involves: 129 * C57BL/6 		abnormal humoral immune response J:71174
decreased B cell number J:71174
decreased B cell proliferation J:71174
decreased B-1 B cell number J:71174
decreased IgA level J:71174
decreased IgG1 level J:71174
decreased IgG2b level J:71174
decreased IgM level J:71174
Cd19tm1Tft/Cd19tm1Tft
involves: 129/Sv * C57BL/6 		decreased neutrophil cell number J:66111
decreased tumor necrosis factor secretion J:66111
increased susceptibility to induced morbidity/mortality J:66111
increased susceptibility to injury J:66111
Cd19tm1Tft/Cd19tm1Tft
Not Specified 		abnormal B cell physiology J:27236
decreased B cell number J:27236
decreased B cell proliferation J:27236
decreased B-1 B cell number J:27236
decreased IgA level J:27236
decreased IgG1 level J:27236
decreased IgG2a level J:27236
decreased IgG2b level J:27236
decreased IgG3 level J:27236
decreased IgM level J:27236
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory