Cd22 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd22
CD22 antigen
MGI:88322

49 phenotypes from 17 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd22^m1Anu/Cd22^m1Anu C57BL/6JAnu-Cd22^m1Anu/AnuApb	arrested B cell differentiation	J:104190
Cd22^m1Anu/Cd22^m1Anu C57BL/6JAnu-Cd22^m1Anu/AnuApb	decreased B cell number	J:104190
Cd22^m1Btlr/Cd22^m1Btlr C57BL/6J-Cd22^m1Btlr	abnormal B cell differentiation	J:173079
Cd22^m1Btlr/Cd22^m1Btlr C57BL/6J-Cd22^m1Btlr	abnormal humoral immune response	J:173079
Cd22^m1Btlr/Cd22^m1Btlr involves: C57BL/6J	abnormal B cell differentiation	J:185495
	decreased IgM level	J:185495
	normal immune system phenotype	J:185495
Cd22^m2Btlr/Cd22^m2Btlr C57BL/6J-Cd22^m2Btlr	abnormal B cell differentiation	J:215821
Cd22^m2Btlr/Cd22^m2Btlr C57BL/6J-Cd22^m2Btlr	abnormal CD4-positive, alpha-beta T cell physiology	J:215821
Cd22^m3Btlr/Cd22^m3Btlr C57BL/6J-Cd22^m3Btlr	decreased B cell number	J:220066
Cd22^m3Btlr/Cd22^m3Btlr C57BL/6J-Cd22^m3Btlr	increased B-1a cell number	J:220066
Cd22^m4Btlr/Cd22^m4Btlr C57BL/6J-Cd22^m4Btlr	decreased B cell number	J:224660
	decreased B-2 B cell number	J:224660
	decreased memory B cell number	J:224660
	increased B-1a cell number	J:224660
Cd22^m5Btlr/Cd22^m5Btlr C57BL/6J-Cd22^m5Btlr	decreased B cell number	J:254827
	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:254827
	increased CD8-positive, alpha-beta memory T cell number	J:254827
Cd22^{tm1.1(CD22)Lnit}/Cd22^{tm1.1(CD22)Lnit} involves: 129S4/SvJae	abnormal B cell calcium ion homeostasis	J:189017
	abnormal B cell physiology	J:189017
	decreased B cell number	J:189017
	decreased marginal zone B cell number	J:189017
	decreased transitional stage T1 B cell number	J:189017
	decreased transitional stage T2 B cell number	J:189017
	normal immune system phenotype	J:189017
	impaired B cell migration	J:189017
Cd22^{tm1b(EUCOMM)Wtsi}/Cd22^{tm1b(EUCOMM)Wtsi} C57BL/6N-Cd22^{tm1b(EUCOMM)Wtsi}/Tcp	hydrometra	J:211773
	increased circulating cholesterol level	J:211773
	increased monocyte cell number	J:211773
	increased startle reflex	J:211773
	small superior vagus ganglion	J:211773
Cd22^tm1Eac/Cd22^tm1Eac involves: 129P2/OlaHsd * C57BL/6	abnormal B cell activation	J:37451
	abnormal B cell proliferation	J:37451, J:132991
	abnormal mature B cell morphology	J:37451
	abnormal transitional stage B cell morphology	J:132991
	decreased IgG1 level	J:37451
	decreased IgG3 level	J:37451
	decreased IgM level	J:37451
	decreased marginal zone B cell number	J:132991
	decreased mature B cell number	J:37451, J:132991
	decreased memory B cell number	J:37451
	increased B cell apoptosis	J:132991
Cd22^tm1Lam/Cd22^tm1Lam involves: 129 * C57BL/6	abnormal B cell activation	J:125719
	decreased marginal zone B cell number	J:125719
	decreased mature B cell number	J:125719
Cd22^tm1Lnit/Cd22^tm1Lnit involves: 129P2/OlaHsd * C57BL/6	decreased marginal zone B cell number	J:198790
Cd22^tm1Lnit/Cd22^tm1Lnit involves: 129P2/OlaHsd * C57BL/6	normal immune system phenotype	J:198790
Cd22^tm1Msn/Cd22^tm1Msn either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6J)	abnormal B cell activation	J:76974
	abnormal B cell calcium ion homeostasis	J:76974
	abnormal immune system physiology	J:76974
	abnormal immunoglobulin level	J:76974
	abnormal mature B cell morphology	J:76974
	increased anti-double stranded DNA antibody level	J:76974, J:76975
	increased B-1 B cell number	J:76974
	increased IgG2a level	J:76975
	increased IgG level	J:76975
	increased IgM level	J:76974
	premature death	J:76975
Cd22^tm1Tft/Cd22^tm1Tft involves: 129P2/OlaHsd * C57BL/6	decreased B cell number	J:92736
	decreased marginal zone B cell number	J:92736
	decreased mature B cell number	J:92736
	increased B cell proliferation	J:92736
Cd22^tm2Lnit/Cd22^tm2Lnit involves: 129P2/OlaHsd * C57BL/6	absent mature B cells	J:198790
	autoimmune response	J:198790
	decreased marginal zone B cell number	J:198790
	normal immune system phenotype	J:198790
Cd22^tm2Tft/Cd22^tm2Tft involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal peripheral B cell anergy	J:208364
	decreased B cell number	J:208364
	decreased B cell proliferation	J:208364
	increased activation-induced B cell apoptosis	J:208364
Cd22^tm2Tft/Cd22^tm2Tft involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	decreased B cell number	J:92736
	decreased B cell proliferation	J:92736
	increased B cell proliferation	J:92736
Cd22^tm3Lnit/Cd22^tm3Lnit involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal B cell physiology	J:198790
	abnormal immune system morphology	J:198790
	abnormal immune system physiology	J:198790
	absent mature B cells	J:198790
	autoimmune response	J:198790
	decreased B cell number	J:198790
	decreased cell migration	J:198790
	decreased marginal zone B cell number	J:198790
	decreased transitional stage B cell number	J:198790
	normal immune system phenotype	J:198790
	increased B cell apoptosis	J:198790
	increased IgG1 level	J:198790
Cd22^tm3Tft/Cd22^tm3Tft involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	decreased B cell number	J:92736
	decreased B cell proliferation	J:92736
	increased B cell proliferation	J:92736

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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