Cd28 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd28
CD28 antigen
MGI:88327

55 phenotypes from 8 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd28^tm1.1Huen/Cd28^tm1.1Huen Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ involves: C57BL/6 * C57BL/6NTac	abnormal regulatory T cell physiology	J:191101
	decreased regulatory T cell number	J:191101
Cd28^{tm1a(EUCOMM)Hmgu}/Cd28^{tm1a(EUCOMM)Hmgu} C57BL/6N-Cd28^{tm1a(EUCOMM)Hmgu}/H	decreased T cell number	J:165965
	increased CD4-positive, alpha-beta T cell number	J:165965
	increased leukocyte cell number	J:165965
Cd28^tm1Jmg/Cd28^tm1Jmg B6.129X1-Cd28^tm1Jmg	decreased interleukin-2 secretion	J:149888
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:149888
	increased susceptibility to type I hypersensitivity reaction	J:149888
Cd28^tm1Jmg/Cd28^tm1Jmg involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	abnormal cytokine secretion	J:124570
	abnormal germinal center B cell physiology	J:124570
	abnormal lymphopoiesis	J:124570
	decreased immunoglobulin level	J:124570
	decreased interleukin-2 secretion	J:124570
Cd28^tm1Jmg/Cd28^tm1Mak involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	abnormal cytokine secretion	J:124570
	abnormal germinal center B cell physiology	J:124570
	abnormal lymphopoiesis	J:124570
	decreased immunoglobulin level	J:124570
	decreased interleukin-2 secretion	J:124570
	decreased T cell proliferation	J:124570, J:149888
Cd28^tm1Ltu/Cd28^tm1Ltu Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal eyelid morphology	J:194503
	decreased locomotor activity	J:194503
	decreased regulatory T cell number	J:194503
	decreased T cell proliferation	J:194503
	enlarged lymph nodes	J:194503
	enlarged spleen	J:194503
	focal hair loss	J:194503
	hunched posture	J:194503
	increased activated T cell number	J:194503
	increased B cell number	J:194503
	increased susceptibility to autoimmune disorder	J:194503
	increased susceptibility to experimental autoimmune encephalomyelitis	J:194503
	ruffled hair	J:194503
	skin inflammation	J:194503
	skin lesions	J:194503
Cd28^tm1Mak/Cd28^tm1Mak B6.129S2-Cd28^tm1Mak	abnormal cytotoxic T cell physiology	J:76373
Cd28^tm1Mak/Cd28^tm1Mak B6.129S2-Cd28^tm1Mak/J	brain inflammation	J:57613
Cd28^tm1Mak/Cd28^tm1Mak B6.129S2-Cd28^tm1Mak/J	decreased susceptibility to experimental autoimmune encephalomyelitis	J:57613
Cd28^tm1Mak/Cd28^tm1Mak involves: 129S2/SvPas	abnormal class switch recombination	J:123989
	abnormal regulatory T cell physiology	J:191101
	decreased interferon-gamma secretion	J:205441
	decreased interleukin-2 secretion	J:130882, J:205441
	decreased regulatory T cell number	J:191101, J:205441
	decreased spleen germinal center number	J:123989
	decreased T cell proliferation	J:123989, J:130882, J:205441
	enlarged thymus	J:205441
Cd28^tm1Mak/Cd28^tm1Mak involves: 129S2/SvPas * C57BL/6	abnormal NK cell physiology	J:95353
	decreased circulating interferon-gamma level	J:95353
	decreased circulating interleukin-4 level	J:95353
	decreased interleukin-2 secretion	J:149888
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:149888
	decreased T cell proliferation	J:149888
	increased susceptibility to type I hypersensitivity reaction	J:149888
	increased T cell apoptosis	J:149888
Cd28^tm1Mak/Cd28^tm1Mak involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:14194
	abnormal class switch recombination	J:14194
	decreased IgG1 level	J:14194
	decreased IgG2b level	J:14194
	decreased immunoglobulin level	J:14194
	decreased interleukin-2 secretion	J:14194
	decreased T cell proliferation	J:14194
	increased IgG2a level	J:14194
Cd28^tm1Mak/Cd28^tm1Mak involves: 129S2/SvPas * NOD	abnormal T-helper 1 physiology	J:35353
	abnormal T-helper 2 physiology	J:35353
	decreased IgG2a level	J:35353
	decreased interleukin-2 secretion	J:35353
	decreased interleukin-4 secretion	J:35353
	decreased T cell proliferation	J:35353
	increased interferon-gamma secretion	J:35353
	increased susceptibility to autoimmune diabetes	J:35353
Cd28^tm1Mak/Cd28^tm1Mak NOD.129S2-Cd28^tm1Mak	abnormal CD4-positive, alpha-beta T cell physiology	J:61905
	abnormal response to transplant	J:61905
	increased susceptibility to autoimmune diabetes	J:93421
	increased T cell proliferation	J:93421
Cd28^tm1Pjl/Cd28^tm1Pjl involves: 129P2/OlaHsd * C57BL/6	abnormal class switch recombination	J:83722
	abnormal cytotoxic T cell physiology	J:83722
	abnormal immunoglobulin level	J:83722
	decreased IgG1 level	J:83722
	decreased IgG2a level	J:83722
	decreased IgM level	J:83722
	decreased interleukin-12 secretion	J:83722
	decreased susceptibility to type IV hypersensitivity reaction	J:83722
	increased splenocyte proliferation	J:83722
Cd28^tm1Shr/Cd28^tm1Shr involves: 129S4/SvJae * BALB/c * C57BL/6	decreased CD4-positive, alpha-beta T cell number	J:68642
	decreased interleukin-2 secretion	J:68642
	decreased T cell proliferation	J:68642
Cd28^tm2.1Jmg/Cd28^tm2.1Jmg B6.129X1-Cd28^tm2.1Jmg	no abnormal phenotype detected	J:149888

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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