Cd28 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd28
CD28 antigen
MGI:88327

39 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cd28^tm1Mak/Cd28⁺ Cd5^tm1Cgn/Cd5^tm1Cgn either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)	abnormal T cell clonal deletion	J:110925
Cd28^tm1Mak/Cd28^tm1Mak Cd5^tm1Cgn/Cd5⁺ either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)	abnormal T cell clonal deletion	J:110925
Cd28^tm1Mak/Cd28^tm1Mak Cd5^tm1Cgn/Cd5^tm1Cgn either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)	abnormal T cell clonal deletion	J:110925
	increased CD4-positive, alpha-beta T cell number	J:110925
	increased CD8-positive, alpha-beta T cell number	J:110925
Cd28^tm1Mak/Cd28^tm1Mak Cd40lg^tm1Flv/Cd40lg^tm1Flv NOD.Cg-Cd40lg^tm1Flv Cd28^tm1Mak	decreased regulatory T cell number	J:93421
	increased susceptibility to autoimmune diabetes	J:93421
	insulitis	J:93421
Cd28^tm1Mak/Cd28^tm1Mak Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg} involves: 129P2/OlaHsd * 129S2/SvPas	abnormal esophageal epithelium morphology	J:205692
	esophageal inflammation	J:205692
	increased eosinophil cell number	J:205692
	increased interleukin-2 secretion	J:205692
	increased interleukin-4 secretion	J:205692
Cd28^tm1Mak/Cd28^tm1Mak Rc3h1^san/Rc3h1⁺ involves: 129S2/SvPas * C57BL/6 * C57BL/6JSfdAnu	decreased lymphoma incidence	J:189087
	increased T cell derived lymphoma incidence	J:189087
Cd28^tm1Mak/Cd28^tm1Mak Stat6^tm1Gru/Stat6^tm1Gru C.129S2(B6)-Cd28^tm1Mak Stat6^tm1Gru	increased susceptibility to parasitic infection	J:90987
Cd28^tm1Mak/Cd28^tm1Mak Tg(Cd4-cre)1Cwi/? Traf6^tm2Ywc/Traf6^tm2Ywc involves: 129S2/SvPas * C57BL/6 * DBA/2	decreased interleukin-2 secretion	J:130882
	decreased T cell proliferation	J:130882
	increased activated T cell number	J:130882
	increased memory T cell number	J:130882
Cd28^tm1Mak/Cd28^tm1Mak Tg(H2-K-Cd86)7All/0 involves: BALB/c * C57BL/6 * CBA	abnormal T cell differentiation	J:112266
Cd28^tm1Mak/Cd28^tm1Mak Tg(TcrLCMV)327Sdz/0 involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal T cell anergy	J:123989
	decreased cytotoxic T cell cytolysis	J:123989
	decreased splenocyte proliferation	J:123989
	decreased T cell proliferation	J:123989
Cd28^tm1Mak/Cd28^tm1Mak Tnfsf9^tm1Thw/Tnfsf9^tm1Thw involves: 129 * 129S2/SvPas * C57BL/6	abnormal cytotoxic T cell physiology	J:76373
	increased length of allograft survival	J:76373
Cd28^tm1Mak/Cd28^tm1Mak Tnfsf14^tm1Kpf/Tnfsf14^tm1Kpf involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	increased length of allograft survival	J:77250
Cd28^tm1Pjl/Cd28^tm1Pjl Tg(DO11.10)10Dlo/0 involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6	abnormal T cell activation	J:25536
	abnormal T cell proliferation	J:25536
	abnormal thymocyte activation	J:25536
	decreased interleukin-2 secretion	J:25536
Cd28^tm1Pjl/Cd28^tm1Pjl Tg(H2-K-Cd86)27All/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	decreased B cell number	J:112475
Cd28^tm1Pjl/Cd28^tm1Pjl Tnfrsf9^tm1Byk/Tnfrsf9^tm1Byk either: B6.Cg-Cd28^tm1Pjl Tnfrsf9^tm1Byk or C.Cg-Cd28^tm1Pjl Tnfrsf9^tm1Byk	abnormal class switch recombination	J:83722
	abnormal cytotoxic T cell physiology	J:83722
	decreased IgG1 level	J:83722
	decreased IgG2a level	J:83722
	decreased IgM level	J:83722
	decreased interleukin-12 secretion	J:83722
	decreased splenocyte proliferation	J:83722
	decreased susceptibility to type IV hypersensitivity reaction	J:83722
Cd28^tm1Shr/Cd28^tm1Shr Ctla4^tm1Shr/Ctla4⁺ C.129S4-Cd28^tm1Shr Ctla4^tm1Shr	abnormal CD8-positive, alpha beta T cell morphology	J:125259
	increased susceptibility to autoimmune disorder	J:125259
Cd28^tm1Shr/Cd28^tm1Shr Ctla4^tm1Shr/Ctla4^tm1Shr C.129S4-Cd28^tm1Shr Ctla4^tm1Shr	abnormal interferon level	J:68642
	abnormal interleukin secretion	J:68642
	decreased CD4-positive, alpha-beta T cell number	J:68642
	decreased T cell proliferation	J:68642
	increased length of allograft survival	J:68642

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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