Cd3e Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd3e
CD3 antigen, epsilon polypeptide
MGI:88332

19 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cd3e^tm1.1Geno/Cd3e^tm1.1Geno Tg(TcraH-Y,TcrbH-Y)71Vbo/0 involves: C57BL/6 * C57BL/6J * DBA/2J	abnormal negative T cell selection	J:192604
	abnormal positive T cell selection	J:192604
	increased DN3 thymocyte number	J:192604
Cd3e^tm1.1Geno/Cd3e^tm1.1Geno Tg(TcrAND)53Hed/0 involves: C57BL/6 * SJL	abnormal CD4-positive T cell differentiation	J:192604
	abnormal positive T cell selection	J:192604
	increased DN3 thymocyte number	J:192604
Cd3e^tm1.1Geno/Cd3e^tm1.1Geno Tg(TcraTcrb)1100Mjb/0 involves: C57BL/6	abnormal positive T cell selection	J:192604
	abnormal T cell differentiation	J:192604
	abnormal thymus cell ratio	J:192604
	decreased double-positive T cell number	J:192604
	decreased T cell number	J:192604
	increased DN3 thymocyte number	J:192604
Cd3e^tm1.1Lov/Cd3e^tm1.1Lov Trdc^tm1Mal/Trdc^tm1Mal involves: C57BL/6	abnormal double-negative T cell morphology	J:112658
Cd3e^tm1Cpt/Cd3e^tm1Cpt Tg(CD3E)26Cpt/0 involves: 129S4/SvJae * C57BL/6 * CBA	decreased double-positive T cell number	J:54756
	decreased T cell number	J:54756
	thymus hypoplasia	J:54756
Cd3e^tm1Mal/Cd3e^tm1Mal Lat^tm1.1Mal/Lat^tm1.1Mal involves: 129S2/SvPas * C57BL/6	absent CD4-positive, alpha-beta T cells	J:77098
	absent CD8-positive, alpha-beta T cells	J:77098
	arrested T cell differentiation	J:77098
	normal immune system phenotype	J:77098
Cd3e^tm1Mal/Cd3e^tm1Mal Nlrp1a^Neut1/Nlrp1a^Neut1 involves: C57BL/6	increased neutrophil cell number	J:191055
	increased susceptibility to infection induced morbidity/mortality	J:191055
	skin inflammation	J:191055
Cd3e^tm1Mal/Cd3e^tm1Mal Tg(Tcrb-TCF3/PBX1)23Gusa/0 involves: C3H * C57BL/6 * C57BL/6J	increased acute lymphoblastic leukemia incidence	J:95693
	increased leukemia incidence	J:95693

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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