Cd4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd4
CD4 antigen
MGI:88335

30 phenotypes from 11 alleles in 16 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd4^del/Cd4^del C57BR/cdJ-Cd4^del	abnormal immune system organ morphology	J:46692
	abnormal lymph node T cell domain morphology	J:46692
	abnormal spleen morphology	J:46692
	absent CD4-positive, alpha-beta T cells	J:46692
	decreased IgG level	J:46692
	decreased IgM level	J:46692
	decreased immunoglobulin level	J:46692
	increased CD8-positive, alpha-beta T cell number	J:46692
Cd4^em1Litt/Cd4^em1Litt involves: C57BL/6J	normal immune system phenotype	J:333574
Cd4^m1Btlr/Cd4^m1Btlr C57BL/6J-Cd4^m1Btlr	absent CD4-positive, alpha-beta T cells	J:212900
Cd4^m1Btlr/Cd4^m1Btlr C57BL/6J-Cd4^m1Btlr	impaired humoral immune response	J:212900
Cd4^maat/Cd4^maat C57BL/6JAnu-Cd4^maat/Apb	abnormal CD4-positive, alpha beta T cell morphology	J:104190
	abnormal double-positive T cell morphology	J:104190
	decreased CD4-positive, alpha-beta T cell number	J:104190
	increased CD8-positive, alpha-beta T cell number	J:104190
Cd4^sesh/Cd4^sesh C57BL/6JAnu-Cd4^sesh/AnuApb	abnormal CD4-positive, alpha beta T cell morphology	J:104190
	abnormal double-positive T cell morphology	J:104190
	decreased T cell number	J:104190
Cd4^thth/Cd4^thth C57BL/6JSfdAnu-Cd4^thth	absent CD4-positive, alpha-beta T cells	J:104190
Cd4^tm1Jrp/Cd4^tm1Jrp either: B6.129S2-Cd4^tm1Jrp or B10.Cg-Cd4^tm1Jrp	abnormal T cell differentiation	J:45168
	decreased CD4-positive, alpha-beta T cell number	J:45168
	decreased double-positive T cell number	J:45168
	increased CD8-positive, alpha-beta T cell number	J:45168
Cd4^tm1Knw/Cd4^tm1Knw B6.129S-Cd4^tm1Knw/J	decreased CD4-positive, alpha-beta T cell number	J:87828
	increased CD8-positive, alpha-beta T cell number	J:87828
	increased susceptibility to parasitic infection	J:87828
Cd4^tm1Knw/Cd4^tm1Knw NOD.Cg-Cd4^tm1Knw	decreased susceptibility to autoimmune diabetes	J:93553
Cd4^tm1Litt/Cd4^tm1Litt involves: 129S2/SvPas	abnormal CD4-positive, alpha-beta T cell physiology	J:50435
	absent CD4-positive, alpha-beta T cells	J:50435
	decreased CD4-positive, alpha-beta T cell number	J:158962
	decreased T cell proliferation	J:50435
	increased CD8-positive, alpha-beta T cell number	J:50435, J:158962
Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3778Nik/0 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:73479
	abnormal interleukin-4 secretion	J:73479
	abnormal T-helper 2 physiology	J:73479
	decreased T cell proliferation	J:73479
Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3785Nik/0 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:73479
	decreased CD4-positive, alpha-beta T cell number	J:73479
	increased CD8-positive, alpha-beta T cell number	J:73479
	increased T cell apoptosis	J:73479
	increased T cell proliferation	J:73479
Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-icre)3779Nik/0 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:73479
	decreased T cell proliferation	J:73479
Cd4^tm1Mak/Cd4^tm1Mak B6.129S2-Cd4^tm1Mak/J	abnormal bile salt level	J:133047
	absent plasma cells	J:133047
	normal immune system phenotype	J:133047
Cd4^tm1Mak/Cd4^tm1Mak involves: 129S2/SvPas	normal immune system phenotype	J:110749
Cd4^tm1Mak/Cd4^tm1Mak involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:68957
	demyelination	J:92227
	increased CD8-positive, alpha-beta T cell number	J:68957
	increased susceptibility to Picornaviridae infection	J:92227
Cd4^tm1Mak/Cd4^tm1Mak PL.129S2(B6)-Cd4^tm1Mak/Rdgz	brain inflammation	J:92227
	demyelination	J:92227
	increased susceptibility to Picornaviridae infection	J:92227
Cd4^tm1Mak/Cd4^tm1Mak SJL.129S2(B6)-Cd4^tm1Mak/Rdgz	brain inflammation	J:92227
	demyelination	J:92227
	increased susceptibility to Picornaviridae infection	J:92227
Cd4^tm1Nik/Cd4^tm1Nik Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺ involves: 129X1/SvJ	abnormal regulatory T cell physiology	J:152472

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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