Cd4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd4
CD4 antigen
MGI:88335

30 phenotypes from 11 alleles in 16 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd4^del/Cd4^del C57BR/cdJ-Cd4^del	abnormal immune system organ morphology	J:46692
	abnormal lymph node T cell domain morphology	J:46692
	abnormal spleen morphology	J:46692
	absent CD4-positive, alpha-beta T cells	J:46692
	decreased IgG level	J:46692
	decreased IgM level	J:46692
	decreased immunoglobulin level	J:46692
	increased CD8-positive, alpha-beta T cell number	J:46692
Cd4^em1Litt/Cd4^em1Litt involves: C57BL/6J	normal immune system phenotype	J:333574
Cd4^m1Btlr/Cd4^m1Btlr C57BL/6J-Cd4^m1Btlr	absent CD4-positive, alpha-beta T cells	J:212900
Cd4^m1Btlr/Cd4^m1Btlr C57BL/6J-Cd4^m1Btlr	impaired humoral immune response	J:212900
Cd4^maat/Cd4^maat C57BL/6JAnu-Cd4^maat/Apb	abnormal CD4-positive, alpha beta T cell morphology	J:104190
	abnormal double-positive T cell morphology	J:104190
	decreased CD4-positive, alpha-beta T cell number	J:104190
	increased CD8-positive, alpha-beta T cell number	J:104190
Cd4^sesh/Cd4^sesh C57BL/6JAnu-Cd4^sesh/AnuApb	abnormal CD4-positive, alpha beta T cell morphology	J:104190
	abnormal double-positive T cell morphology	J:104190
	decreased T cell number	J:104190
Cd4^thth/Cd4^thth C57BL/6JSfdAnu-Cd4^thth	absent CD4-positive, alpha-beta T cells	J:104190
Cd4^tm1Jrp/Cd4^tm1Jrp either: B6.129S2-Cd4^tm1Jrp or B10.Cg-Cd4^tm1Jrp	abnormal T cell differentiation	J:45168
	decreased CD4-positive, alpha-beta T cell number	J:45168
	decreased double-positive T cell number	J:45168
	increased CD8-positive, alpha-beta T cell number	J:45168
Cd4^tm1Knw/Cd4^tm1Knw B6.129S-Cd4^tm1Knw/J	decreased CD4-positive, alpha-beta T cell number	J:87828
	increased CD8-positive, alpha-beta T cell number	J:87828
	increased susceptibility to parasitic infection	J:87828
Cd4^tm1Knw/Cd4^tm1Knw NOD.Cg-Cd4^tm1Knw	decreased susceptibility to autoimmune diabetes	J:93553
Cd4^tm1Litt/Cd4^tm1Litt involves: 129S2/SvPas	abnormal CD4-positive, alpha-beta T cell physiology	J:50435
	absent CD4-positive, alpha-beta T cells	J:50435
	decreased CD4-positive, alpha-beta T cell number	J:158962
	decreased T cell proliferation	J:50435
	increased CD8-positive, alpha-beta T cell number	J:50435, J:158962
Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3778Nik/0 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:73479
	abnormal interleukin-4 secretion	J:73479
	abnormal T-helper 2 physiology	J:73479
	decreased T cell proliferation	J:73479
Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3785Nik/0 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:73479
	decreased CD4-positive, alpha-beta T cell number	J:73479
	increased CD8-positive, alpha-beta T cell number	J:73479
	increased T cell apoptosis	J:73479
	increased T cell proliferation	J:73479
Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-icre)3779Nik/0 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:73479
	decreased T cell proliferation	J:73479
Cd4^tm1Mak/Cd4^tm1Mak B6.129S2-Cd4^tm1Mak/J	abnormal bile salt level	J:133047
	absent plasma cells	J:133047
	normal immune system phenotype	J:133047
Cd4^tm1Mak/Cd4^tm1Mak involves: 129S2/SvPas	normal immune system phenotype	J:110749
Cd4^tm1Mak/Cd4^tm1Mak involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:68957
	demyelination	J:92227
	increased CD8-positive, alpha-beta T cell number	J:68957
	increased susceptibility to Picornaviridae infection	J:92227
Cd4^tm1Mak/Cd4^tm1Mak PL.129S2(B6)-Cd4^tm1Mak/Rdgz	brain inflammation	J:92227
	demyelination	J:92227
	increased susceptibility to Picornaviridae infection	J:92227
Cd4^tm1Mak/Cd4^tm1Mak SJL.129S2(B6)-Cd4^tm1Mak/Rdgz	brain inflammation	J:92227
	demyelination	J:92227
	increased susceptibility to Picornaviridae infection	J:92227
Cd4^tm1Nik/Cd4^tm1Nik Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺ involves: 129X1/SvJ	abnormal regulatory T cell physiology	J:152472

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24