Cd4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd4
CD4 antigen
MGI:88335

37 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B2m^tm1Jae/B2m^tm1Jae Cd4^tm1Jrp/Cd4^tm1Jrp involves: 129S2/SvPas * C57BL/6	increased CD8-positive, alpha-beta T cell number	J:45168
B2m^tm1Unc/B2m^tm1Unc Cd4^tm1Mak/Cd4^tm1Mak Cd8a^{tm2.1(Cd4)Asin}/Cd8a^{tm2.1(Cd4)Asin} involves: 129 * C57BL/6	abnormal T cell physiology	J:180236
Cd4^em1Litt/Cd4^em1Litt Rr386^em1Pdi/Rr386^em1Pdi involves: C57BL/6J	abnormal lymphocyte activation involved in immune response	J:333574
	decreased T helper 1 cell number	J:333574
	normal immune system phenotype	J:333574
Cd4^{tm1(cre/ERT2)Thbu}/Cd4⁺ Tgfbr2^tm1Karl/Tgfbr2^tm1Karl involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal growth/size/body region phenotype	J:204579
	normal immune system phenotype	J:204579
	increased memory T cell number	J:204579
	increased regulatory T cell number	J:204579
Cd4^{tm1(cre/ERT2)Thbu}/Cd4⁺ Gfm1^{tm1c(EUCOMM)Wtsi}/Gfm1^{tm1c(EUCOMM)Wtsi} involves: C57BL/6 * C57BL/6N * SJL	abnormal T-helper 17 cell differentiation	J:302272
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:302272
	increased CD8-positive, alpha-beta T cell number	J:302272
	increased single-positive T cell number	J:302272
Cd4^tm1Doi/Cd4^tm1Doi Lag3^tm1Doi/Lag3^tm1Doi involves: 129 * C57BL/6	abnormal CD4-positive, alpha-beta T cell physiology	J:33272
	increased double-negative T cell number	J:33272
Cd4^tm1Doi/Cd4^tm1Litt Lag3^tm1Doi/Lag3⁺ involves: 129 * C57BL/6	abnormal CD4-positive, alpha-beta T cell physiology	J:33272
	increased double-negative T cell number	J:33272
Cd4^tm1Jrp/Cd4^tm1Jrp Tg(TcrAND)53Hed/0 either: (involves: 129S2/SvPas * C57BL/6 * SJL) or (involves: 129S2/SvPas * C57BL/6 * C57BL/10 * SJL)	abnormal T cell number	J:45168
	thymus hyperplasia	J:45168
Cd4^tm1Knw/Cd4^tm1Knw Tg(TcraAI4)1Dvs/0 Tg(TcrbAI4)1Dvs/0 NOD.Cg-Cd4^tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs	increased susceptibility to autoimmune diabetes	J:93553
Cd4^tm1Knw/Cd4^tm1Knw Tgfb1^tm1Doe/Tgfb1^tm1Doe involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1	premature death	J:99033
Cd4^tm1Litt/Cd4^tm1Litt Foxp3^sf Otc^spf/Y involves: 129/Rl * 129S2/SvPas	abnormal CD8-positive, alpha beta T cell morphology	J:20865
	abnormal cytokine secretion	J:20865
	abnormal immune system organ morphology	J:20865
	enlarged lymph nodes	J:20865
	increased IgG level	J:20865
	increased IgM level	J:20865
	increased interleukin-4 secretion	J:20865
	increased interleukin-6 secretion	J:20865
	increased tumor necrosis factor secretion	J:20865
	premature death	J:20865
Cd4^tm1Litt/Cd4^tm1Litt Tg(Cd4-CD4)2362Litt/0 involves: 129S2/SvPas * C57BL/6 * SJL	normal immune system phenotype	J:50435
Cd4^tm1Mak/Cd4^tm1Mak Cd8a^tm1Mak/Cd8a^tm1Mak involves: 129S2/SvPas	increased susceptibility to viral infection	J:110749
Cd4^tm1Mak/Cd4^tm1Mak Cd8a^tm1Mak/Cd8a^tm1Mak involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal double-negative T cell morphology	J:12572
	abnormal gamma-delta T cell number	J:12572
	abnormal T cell differentiation	J:12572
	abnormal T cell number	J:12572
	decreased cytotoxic T cell cytolysis	J:12572
	decreased double-positive T cell number	J:12572
	increased length of allograft survival	J:12572
	small thymus medulla	J:12572
Cd4^tm1Mak/Cd4^tm1Mak Igh-J^{tm2(3H9-VDJ)Mwg}/Igh-J⁺ B6.Cg-Cd4^tm1Mak Igh-J^{tm2(3H9-VDJ)Mwg}	increased anti-double stranded DNA antibody level	J:142389
Cd4^tm1Mak/Cd4^tm1Mak Irf2^tm1Mak/Irf2^tm1Mak involves: 129S2/SvPas * C57BL/6	abnormal skin condition	J:66034
Cd4^tm1Mak/Cd4^tm1Mak Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S2/SvPas * C57BL/6J	premature death	J:108572
	small intestinal inflammation	J:108572

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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