Cd40 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd40
CD40 antigen
MGI:88336

28 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Bank1^tm1Kuro/Bank1^tm1Kuro Cd40^tm1Kik/Cd40^tm1Kik involves: 129P2/OlaHsd	normal immune system phenotype	J:113321
Btk^tm1Wk/Btk^tm1Wk Cd40^tm1Geha/Cd40^tm1Geha involves: 129S4/SvJae * C57BL/6	abnormal humoral immune response	J:82298
	absent lymph node germinal center	J:82298
	absent spleen germinal center	J:82298
	decreased B cell number	J:82298
	decreased B cell proliferation	J:82298
	decreased IgA level	J:82298
	decreased IgG2a level	J:82298
	decreased IgG2b level	J:82298
	decreased IgG3 level	J:82298
	decreased IgM level	J:82298
	decreased mature B cell number	J:82298
Cd40^tm1Kik/Cd40⁺ Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cr2-cre)3Cgn/0 involves: 129P2/OlaHsd * C57BL/6	normal immune system phenotype	J:266124
	increased T follicular helper cell number	J:266124
Cd40^tm1Kik/Cd40^tm1Kik Ltbr^tm1Mmat/Ltbr^tm1Mmat involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal thymus epithelium morphology	J:173115
	abnormal thymus medulla morphology	J:173115
	normal immune system phenotype	J:173115
Cd40^tm1Kik/Cd40^tm1Kik Tg(Igh-V-CD40lg)#Tsub/0 involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:89855
Cd40^tm1Kik/Cd40^tm1Kik Tg(Tnfsf13b)1Fma/? B6.Cg-Cd40^tm1Kik Tg(Tnfsf13b)1Fma	abnormal B cell activation	J:113556
	abnormal class switch recombination	J:113556
	absent spleen germinal center	J:113556
	glomerulonephritis	J:113556
	increased anti-double stranded DNA antibody level	J:113556
	increased marginal zone B cell number	J:113556
	increased urine protein level	J:113556
	renal glomerular immunoglobulin deposits	J:113556
Cd40^tm1Kik/Cd40^tm1Kik Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr involves: 129P2/OlaHsd	abnormal thymus epithelium morphology	J:173115
Cd40^tm1Kik/Cd40^tm1Kik Traf3ip2^tm1.1Lix/Traf3ip2^tm1.1Lix involves: 129 * 129P2/OlaHsd * BALB/c	abnormal B cell physiology	J:138560
	enlarged lymph nodes	J:93923
	enlarged spleen	J:93923
	normal immune system phenotype	J:138560
	increased follicular B cell number	J:138560
	increased marginal zone B cell number	J:138560
	increased transitional stage B cell number	J:138560

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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