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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cd44
CD44 antigen
MGI:88338
90 phenotypes from 10 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd44M1Btlr/Cd44M1Btlr
C57BL/6J-Cd44M1Btlr 		alopecia J:267484
decreased alpha-beta T cell number J:267483
decreased CD4-positive, alpha-beta T cell number J:267483
decreased CD8-positive, alpha-beta T cell number J:267483
decreased central memory CD4-positive, alpha-beta T cell number J:267483
decreased central memory CD8 positive, alpha-beta T cell number J:267483
decreased effector memory CD4-positive, alpha-beta T cell number J:267483
Cd44tm1.1Ugu/Cd44tm1.1Ugu
B6.129(Cg)-Cd44tm1.1Ugu 		decreased susceptibility to experimental autoimmune encephalomyelitis J:199279
Cd44tm1.1Ugu/Cd44tm1.1Ugu
involves: 129/Sv * C57BL/6 		abnormal digestive system physiology J:62867
abnormal T-helper 1 physiology J:62867
abnormal T-helper 2 physiology J:62867
normal immune system phenotype J:62867
Cd44tm1.1Ugu/Cd44tm1.1Ugu
SJL.129(Cg)-Cd44tm1.1Ugu 		decreased susceptibility to experimental autoimmune encephalomyelitis J:199279
decreased T cell proliferation J:199279
Cd44tm1Hbg/Cd44tm1Hbg
B6.129-Cd44tm1Hbg 		decreased mast cell histamine storage J:146846
decreased mast cell number J:146846
Cd44tm1Hbg/Cd44tm1Hbg
involves: 129S1/Sv * 129X1/SvJ 		abnormal epidermal lamellar body morphology J:108938
abnormal lipid level J:108938
abnormal osteoclast differentiation J:101563
abnormal response to cardiac infarction J:131974
abnormal response to infection J:86947
decreased cholesterol level J:108938
impaired skin barrier function J:108938
impaired wound healing J:131974
increased acute inflammation J:131974
increased diameter of tibia J:101563
short tibia J:101563
thin epidermis J:108938
Cd44tm1Hbg/Cd44tm1Hbg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal CD4-positive, alpha beta T cell morphology J:68069
abnormal CD8-positive, alpha beta T cell morphology J:68069
abnormal leukocyte migration J:68069
abnormal neutrophil physiology J:94850
choroidal neovascularization J:154560
normal hematopoietic system phenotype J:110964
Cd44tm1Mak/Cd44+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal leukocyte migration J:99032
Cd44tm1Mak/Cd44tm1Mak
B6.129P2-Cd44tm1Mak 		abnormal circulating cytokine level J:69351
abnormal leukocyte migration J:108245
decreased activation-induced cell death of T cells J:69351
decreased myocardial infarct size J:80446
decreased sensitivity to induced cell death J:69351
decreased transforming growth factor beta level J:111216
enhanced coordination J:80446
impaired macrophage phagocytosis J:111216
impaired natural killer cell mediated cytotoxicity J:110889
increased circulating interferon-gamma level J:69351
increased circulating interleukin-2 level J:69351
increased circulating tumor necrosis factor level J:69351
increased mean systemic arterial blood pressure J:80446
increased susceptibility to induced morbidity/mortality J:69351, J:111216
liver inflammation J:69351
lung inflammation J:108245, J:111216
Cd44tm1Mak/Cd44tm1Mak
D1.129P2-Cd44tm1Mak 		increased susceptibility to induced arthritis J:95275
Cd44tm1Mak/Cd44tm1Mak
involves: 129P2/OlaHsd * C57BL/6 		abnormal chemokine secretion J:155691
abnormal circulating chemokine level J:155691
abnormal interleukin secretion J:155691
abnormal miniature excitatory postsynaptic currents J:128984
abnormal physiological neovascularization J:110162
abnormal vascular endothelial cell morphology J:110162
abnormal vascular endothelial cell physiology J:110162
abnormal vasculogenesis J:110162
decreased acute inflammation J:114341
decreased angiogenesis J:110162
decreased blood urea nitrogen level J:114341
decreased circulating creatinine level J:114341
decreased circulating tumor necrosis factor level J:155691
decreased miniature excitatory postsynaptic current frequency J:128984
decreased susceptibility to kidney reperfusion injury J:114341
decreased tumor growth/size J:110162
delayed wound healing J:110162
increased interleukin-1 beta secretion J:155691
increased interleukin-6 secretion J:155691
increased interleukin-10 secretion J:155691
increased miniature excitatory postsynaptic current amplitude J:128984
increased tumor necrosis factor secretion J:155691
peritoneal inflammation J:155691
Cd44tm1Mak/Cd44tm1Mak
involves: 129P2/OlaHsd * C57BL/6J 		abnormal cell morphology J:105319
abnormal cell physiology J:72658
abnormal definitive hematopoiesis J:72658
abnormal leukocyte migration J:99032
abnormal mitochondrial crista morphology J:105319
abnormal vascular smooth muscle physiology J:101783
decreased fibroblast proliferation J:105319
normal immune system phenotype J:72658
increased mitochondrial size J:105319
increased susceptibility to parasitic infection J:72658
Cd44tm1Stpa/Cd44tm1Stpa
B6.Cg-Cd44tm1Stpa 		normal digestive/alimentary phenotype J:204874
Cd44tm1Ugu/Cd44tm1Ugu
involves: 129/Sv * C57BL/6 		abnormal digestive system physiology J:62867
abnormal T-helper 1 physiology J:62867
abnormal T-helper 2 physiology J:62867
normal immune system phenotype J:62867
Cd44tm2.1Ugu/Cd44tm2.1Ugu
B6.129-Cd44tm2.1Ugu 		decreased susceptibility to experimental autoimmune encephalomyelitis J:199279
decreased T cell proliferation J:199279
Cd44tm2Kmz/Cd44tm2Kmz
DBA/1LacJ-Cd44tm2Kmz 		abnormal involution of the mammary gland J:74524
abnormal uterus morphology J:74524
decreased susceptibility to induced arthritis J:74268
Cd44tm2Kmz/Cd44tm2Kmz
involves: BALB/c * DBA/1 		abnormal CD4-positive, alpha-beta T cell physiology J:114317
abnormal leukocyte adhesion J:114317
decreased susceptibility to type IV hypersensitivity reaction J:114317
impaired leukocyte tethering or rolling J:114317
impaired neutrophil recruitment J:114317
Cd44tm2Stpa/Cd44tm2Stpa
B6.Cg-Cd44tm2Stpa 		normal digestive/alimentary phenotype J:204874
Cd44tm2Ugu/Cd44tm2Ugu
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:108416
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory