Cd44 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd44
CD44 antigen
MGI:88338

48 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Adam10^Pied/Adam10⁺ Cd44^tm1Hbg/Cd44^tm1Hbg Hr^hr/Hr^hr involves: 129S1/Sv * 129X1/SvJ * HRA/SkhKcl	abnormal skin pigmentation	J:262499
	hairless	J:262499
Apc^Min/Apc⁺ Cd44^tm1Mak/Cd44^tm1Mak involves: 129P2/OlaHsd * C57BL/6J	decreased intestinal adenoma incidence	J:135025
	increased small intestinal crypt cell apoptosis	J:135025
Apc^Min/Apc⁺ Cd44^tm1Mak/Cd44^tm1Mak involves: C57BL/6J	decreased intestinal adenoma incidence	J:204874
	increased enterocyte apoptosis	J:204874
	increased tumor-free survival time	J:204874
Apc^Min/Apc⁺ Cd44^tm1Stpa/Cd44^tm1Stpa involves: C57BL/6J * C57BL/6JIco	increased intestinal adenoma incidence	J:204874
	premature death	J:204874
Apc^Min/Apc⁺ Cd44^tm1Stpa/Cd44^tm2Stpa involves: C57BL/6J	increased intestinal adenoma incidence	J:204874
Apc^Min/Apc⁺ Cd44^tm2Stpa/Cd44^tm2Stpa involves: C57BL/6J	decreased intestinal adenoma incidence	J:204874
Apc^Min/Apc⁺ Cd44^tm2Stpa/Cd44^tm2Stpa involves: C57BL/6J	increased tumor-free survival time	J:204874
Apoe^tm1Unc/Apoe^tm1Unc Cd44^tm1Mak/Cd44⁺ B6.129P2-Cd44^tm1Mak Apoe^tm1Unc	decreased susceptibility to atherosclerosis	J:72315
Apoe^tm1Unc/Apoe^tm1Unc Cd44^tm1Mak/Cd44^tm1Mak B6.129P2-Cd44^tm1Mak Apoe^tm1Unc	decreased susceptibility to atherosclerosis	J:72315
Cd44^tm1.1Ugu/Cd44^tm1.1Ugu Il10^tm1Cgn/Il10^tm1Cgn involves: 129/Sv * C57BL/6	abnormal immune system physiology	J:62867
	weight loss	J:62867
Cd44^tm1Hbg/Cd44⁺ Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	ileum inflammation	J:145626
Cd44^tm1Hbg/Cd44^tm1Hbg Tg(TNF)197Gkl/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal articular cartilage morphology	J:97992
	abnormal osteoclast differentiation	J:97992
	abnormal osteoclast morphology	J:97992
	autoimmune arthritis	J:97992
	decreased body weight	J:97992
	decreased bone mass	J:97992
	decreased compact bone thickness	J:97992
	decreased grip strength	J:97992
	decreased trabecular bone mass	J:97992
	decreased trabecular bone volume	J:97992
	increased bone resorption	J:97992
	increased circulating interleukin-1 level	J:97992
	increased circulating interleukin-6 level	J:97992
	increased interleukin-1 secretion	J:97992
	increased interleukin-6 secretion	J:97992
	increased osteoclast cell number	J:97992
	joint swelling	J:97992
Cd44^tm1Hbg/Cd44^tm1Hbg Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	normal digestive/alimentary phenotype	J:145626
	normal immune system phenotype	J:145626
Cd44^tm1Mak/Cd44^tm1Mak Gab1^tm1Wbm/Gab1⁺ involves: 129P2/OlaHsd * C57BL/6	lethality, incomplete penetrance	J:128984
	neonatal lethality, incomplete penetrance	J:128984
Cd44^tm1Mak/Cd44^tm1Mak Hgf^tm1Kita/Hgf⁺ involves: 129S4/SvJae * C57BL/6	neonatal lethality, incomplete penetrance	J:128984
Cd44^tm1Mak/Cd44^tm1Mak Itgal^tm1Mak/Itgal^tm1Mak B6.129P2-Cd44^tm1Mak Itgal^tm1Mak	impaired natural killer cell mediated cytotoxicity	J:110889
Cd44^tm1Mak/Cd44^tm1Mak Met^tm1Cbm/Met⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal miniature excitatory postsynaptic currents	J:128984
	abnormal miniature inhibitory postsynaptic currents	J:128984
	abnormal phrenic nerve morphology	J:128984
	decreased miniature inhibitory postsynaptic current frequency	J:128984
	lethality, incomplete penetrance	J:128984
	neonatal lethality, incomplete penetrance	J:128984
	primary atelectasis	J:128984
	respiratory distress	J:128984
Cd44^tm1Mak/Cd44^tm1Mak Tg(MMTV-PyVT)634Mul/0 B6.Cg-Cd44^tm1Mak Tg(MMTV-PyVT)634Mul	increased metastatic potential	J:100774
Cd44^tm1Mak/Cd44^tm1Mak Tg(MMTV-PyVT)634Mul/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	increased metastatic potential	J:100774
Cd44^tm1Mak/Cd44^tm1Mak Trp53^tm1Tyj/Trp53⁺ involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J	decreased metastatic potential	J:76201
	increased lymphoma incidence	J:76201
Cd44^tm2Kmz/Cd44^tm2Kmz Sell^tm2Hyn/Sell^tm2Hyn involves: 129S2/SvPas * BALB/c * DBA/1	abnormal CD4-positive, alpha-beta T cell physiology	J:114317
	abnormal leukocyte adhesion	J:114317
	decreased susceptibility to type IV hypersensitivity reaction	J:114317
	impaired leukocyte tethering or rolling	J:114317
	impaired neutrophil recruitment	J:114317

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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