Cd8a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd8a
CD8 subunit alpha
MGI:88346

15 phenotypes from 7 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd8a^m1Btlr/Cd8a^m1Btlr C57BL/6J-Cd8a^m1Btlr	abnormal CD4-positive T cell differentiation	J:221492
	abnormal CD8-positive, alpha-beta T cell differentiation	J:221492
	increased susceptibility to Herpesvirales infection	J:221492
Cd8a^m2Btlr/Cd8a^m2Btlr C57BL/6J-Cd8a^m2Btlr	abnormal CD8-positive, alpha-beta T cell physiology	J:236677
Cd8a^m2Btlr/Cd8a^m2Btlr C57BL/6J-Cd8a^m2Btlr	increased CD8-positive, alpha-beta memory T cell proliferation	J:236677
Cd8a^{tm1.1(cre)Koni}/Cd8a⁺ involves: C57BL/6J * C57BL/6NHsd * SJL	normal hematopoietic system phenotype	J:177182
	no abnormal phenotype detected	J:177182
Cd8a^{tm1.1(cre)Koni}/Cd8a^{tm1.1(cre)Koni} involves: C57BL/6J * C57BL/6NHsd * SJL	decreased CD8-positive, alpha-beta T cell number	J:177182
Cd8a^tm1.1Kio/Cd8a^tm1.1Kio involves: 129S4/SvJae * C57BL/10 * CBA/Ca	abnormal CD4-positive T cell differentiation	J:76799
Cd8a^tm1.1Litt/Cd8a^tm1.1Litt either: (involves: 129P2/OlaHsd * AKR) or (involves: 129P2/OlaHsd * C57BL/6)	abnormal CD8-positive, alpha beta T cell morphology	J:50624
Cd8a^tm1.1Welm/Cd8a^tm1.1Welm involves: 129P2/OlaHsd * C57BL/6	normal immune system phenotype	J:113136
	no abnormal phenotype detected	J:113136
Cd8a^tm1Mak/Cd8a^tm1Mak B6.129S2-Cd8a^tm1Mak	abnormal response to transplant	J:91742
Cd8a^tm1Mak/Cd8a^tm1Mak involves: 129S2/SvPas	normal immune system phenotype	J:110749
Cd8a^tm1Mak/Cd8a^tm1Mak involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal cytotoxic T cell physiology	J:68956
	absent CD8-positive, alpha-beta T cells	J:68956
	demyelination	J:92227
	increased susceptibility to Picornaviridae infection	J:92227
Cd8a^tm1Mak/Cd8a^tm1Mak PL.129S2(B6)-Cd8a^tm1Mak/Rdgz	demyelination	J:92227
Cd8a^tm1Mak/Cd8a^tm1Mak PL.129S2(B6)-Cd8a^tm1Mak/Rdgz	increased susceptibility to Picornaviridae infection	J:92227
Cd8a^tm1Mak/Cd8a^tm1Mak SJL.129S2(B6)-Cd8a^tm1Mak/Rdgz	demyelination	J:92227
Cd8a^tm1Mak/Cd8a^tm1Mak SJL.129S2(B6)-Cd8a^tm1Mak/Rdgz	increased susceptibility to Picornaviridae infection	J:92227

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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