Cd8a Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd8a
CD8 subunit alpha
MGI:88346

28 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B2m^tm1Unc/B2m^tm1Unc Cd4^tm1Mak/Cd4^tm1Mak Cd8a^{tm2.1(Cd4)Asin}/Cd8a^{tm2.1(Cd4)Asin} involves: 129 * C57BL/6	abnormal T cell physiology	J:180236
Cd4^tm1Mak/Cd4^tm1Mak Cd8a^tm1Mak/Cd8a^tm1Mak involves: 129S2/SvPas	increased susceptibility to viral infection	J:110749
Cd4^tm1Mak/Cd4^tm1Mak Cd8a^tm1Mak/Cd8a^tm1Mak involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal double-negative T cell morphology	J:12572
	abnormal gamma-delta T cell number	J:12572
	abnormal T cell differentiation	J:12572
	abnormal T cell number	J:12572
	decreased cytotoxic T cell cytolysis	J:12572
	decreased double-positive T cell number	J:12572
	increased length of allograft survival	J:12572
	small thymus medulla	J:12572
Cd8a^tm1Asin/Cd8a^tm1Asin involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal double-positive T cell morphology	J:126026
Cd8a^tm1Asin/Cd8a^tm1Asin Cd8b1^tm1Litt/Cd8b1^tm1Litt H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru involves: 129 * FVB/N	decreased CD4-positive, alpha-beta T cell number	J:126026
	increased CD8-positive, alpha-beta T cell number	J:126026
Cd8a^tm1Asin/Cd8a^tm1Asin Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)71Vbo/? involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J	abnormal CD8-positive, alpha beta T cell morphology	J:125259
Cd8a^tm1Asin/Cd8a^tm1Asin Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N	abnormal positive T cell selection	J:126026
	decreased CD4-positive, alpha-beta T cell number	J:126026
	increased CD8-positive, alpha-beta T cell number	J:126026
Cd8a^tm1Asin/Cd8a^tm1Mak involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N	abnormal positive T cell selection	J:126026
	abnormal T cell subpopulation ratio	J:126026
	increased CD8-positive, alpha-beta T cell number	J:126026
Cd8a^tm1Mak/Cd8a^tm1Mak Il15^tm1Imx/Il15^tm1Imx X/Yaa BXSB.Cg-Cd8a^tm1Mak Il15^tm1Imx/Dcr	abnormal spleen B cell follicle morphology	J:179430
	increased anti-nuclear antigen antibody level	J:179430
	increased IgG1 level	J:179430
	increased IgG2a level	J:179430
	increased IgG2b level	J:179430
	increased monocyte cell number	J:179430
	increased splenocyte number	J:179430
	increased susceptibility to systemic lupus erythematosus	J:179430
	premature death	J:179430
	renal glomerular immunoglobulin deposits	J:179430
Cd8a^tm1Mak/Cd8a^tm1Mak Irf2^tm1Mak/Irf2^tm1Mak involves: 129S2/SvPas * C57BL/6	abnormal skin condition	J:66034
Cd8a^tm1Mak/Cd8a^tm1Mak Tgfb1^tm1Doe/Tgfb1^tm1Doe involves: 129S2/SvPas * C57BL/6 * CF-1	premature death	J:99033
Cd8a^tm1Mak/Cd8a^tm1Mak X/Yaa BXSB.129S2(B6)-Cd8a^tm1Mak/4Dcr	increased susceptibility to systemic lupus erythematosus	J:179430
	premature death	J:179430
Cd8a^tm1Mak/Cd8a^tm1Mak Zbtb7b^hd/Zbtb7b^hd involves: B6.129S2-Cd8a^tm1Mak * B6.Cg-Thpok^hd	absent CD4-positive, alpha-beta T cells	J:95867

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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